KEGG   Homo sapiens (human): 4436Help
Entry
4436              CDS       T01001                                 

Gene name
MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Definition
mutS homolog 2
Orthology
K08735  
DNA mismatch repair protein MSH2
Organism
hsa  Homo sapiens (human)
Pathway
Mismatch repair
Pathways in cancer
Colorectal cancer
Module
BRCA1-associated genome surveillance complex (BASC)
Disease
H00020  
Colorectal cancer
H00027  
Ovarian cancer
H00876  
Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Replication and repair
   03430 Mismatch repair
    4436 (MSH2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    4436 (MSH2)
   05210 Colorectal cancer
    4436 (MSH2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
2p21
AA seq 934 aa AA seqDB search
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT
QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA
YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD
LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM
KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL
NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA
LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE
LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS
TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA
QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD
KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK
GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF
ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV
IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMS
EENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
NT seq 2805 nt NT seq  +upstreamnt  +downstreamnt
atggcggtgcagccgaaggagacgctgcagttggagagcgcggccgaggtcggcttcgtg
cgcttctttcagggcatgccggagaagccgaccaccacagtgcgccttttcgaccggggc
gacttctatacggcgcacggcgaggacgcgctgctggccgcccgggaggtgttcaagacc
cagggggtgatcaagtacatggggccggcaggagcaaagaatctgcagagtgttgtgctt
agtaaaatgaattttgaatcttttgtaaaagatcttcttctggttcgtcagtatagagtt
gaagtttataagaatagagctggaaataaggcatccaaggagaatgattggtatttggca
tataaggcttctcctggcaatctctctcagtttgaagacattctctttggtaacaatgat
atgtcagcttccattggtgttgtgggtgttaaaatgtccgcagttgatggccagagacag
gttggagttgggtatgtggattccatacagaggaaactaggactgtgtgaattccctgat
aatgatcagttctccaatcttgaggctctcctcatccagattggaccaaaggaatgtgtt
ttacccggaggagagactgctggagacatggggaaactgagacagataattcaaagagga
ggaattctgatcacagaaagaaaaaaagctgacttttccacaaaagacatttatcaggac
ctcaaccggttgttgaaaggcaaaaagggagagcagatgaatagtgctgtattgccagaa
atggagaatcaggttgcagtttcatcactgtctgcggtaatcaagtttttagaactctta
tcagatgattccaactttggacagtttgaactgactacttttgacttcagccagtatatg
aaattggatattgcagcagtcagagcccttaacctttttcagggttctgttgaagatacc
actggctctcagtctctggctgccttgctgaataagtgtaaaacccctcaaggacaaaga
cttgttaaccagtggattaagcagcctctcatggataagaacagaatagaggagagattg
aatttagtggaagcttttgtagaagatgcagaattgaggcagactttacaagaagattta
cttcgtcgattcccagatcttaaccgacttgccaagaagtttcaaagacaagcagcaaac
ttacaagattgttaccgactctatcagggtataaatcaactacctaatgttatacaggct
ctggaaaaacatgaaggaaaacaccagaaattattgttggcagtttttgtgactcctctt
actgatcttcgttctgacttctccaagtttcaggaaatgatagaaacaactttagatatg
gatcaggtggaaaaccatgaattccttgtaaaaccttcatttgatcctaatctcagtgaa
ttaagagaaataatgaatgacttggaaaagaagatgcagtcaacattaataagtgcagcc
agagatcttggcttggaccctggcaaacagattaaactggattccagtgcacagtttgga
tattactttcgtgtaacctgtaaggaagaaaaagtccttcgtaacaataaaaactttagt
actgtagatatccagaagaatggtgttaaatttaccaacagcaaattgacttctttaaat
gaagagtataccaaaaataaaacagaatatgaagaagcccaggatgccattgttaaagaa
attgtcaatatttcttcaggctatgtagaaccaatgcagacactcaatgatgtgttagct
cagctagatgctgttgtcagctttgctcacgtgtcaaatggagcacctgttccatatgta
cgaccagccattttggagaaaggacaaggaagaattatattaaaagcatccaggcatgct
tgtgttgaagttcaagatgaaattgcatttattcctaatgacgtatactttgaaaaagat
aaacagatgttccacatcattactggccccaatatgggaggtaaatcaacatatattcga
caaactggggtgatagtactcatggcccaaattgggtgttttgtgccatgtgagtcagca
gaagtgtccattgtggactgcatcttagcccgagtaggggctggtgacagtcaattgaaa
ggagtctccacgttcatggctgaaatgttggaaactgcttctatcctcaggtctgcaacc
aaagattcattaataatcatagatgaattgggaagaggaacttctacctacgatggattt
gggttagcatgggctatatcagaatacattgcaacaaagattggtgctttttgcatgttt
gcaacccattttcatgaacttactgccttggccaatcagataccaactgttaataatcta
catgtcacagcactcaccactgaagagaccttaactatgctttatcaggtgaagaaaggt
gtctgtgatcaaagttttgggattcatgttgcagagcttgctaatttccctaagcatgta
atagagtgtgctaaacagaaagccctggaacttgaggagtttcagtatattggagaatcg
caaggatatgatatcatggaaccagcagcaaagaagtgctatctggaaagagagcaaggt
gaaaaaattattcaggagttcctgtccaaggtgaaacaaatgccctttactgaaatgtca
gaagaaaacatcacaataaagttaaaacagctaaaagctgaagtaatagcaaagaataat
agctttgtaaatgaaatcatttcacgaataaaagttactacgtga

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