KEGG T01001: 4624

Homo sapiens (human): 4624

Entry

4624 CDS T01001

Gene name

MYH6, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3, alpha-MHC

Definition

myosin, heavy chain 6, cardiac muscle, alpha

Orthology

K10352

myosin heavy chain

Organism

hsa Homo sapiens (human)

Pathway

hsa04260	Cardiac muscle contraction
hsa04530	Tight junction
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy
hsa05416	Viral myocarditis

Disease

H00292	Hypertrophic cardiomyopathy (HCM)
H00294	Dilated cardiomyopathy (DCM)
H00546	Atrial septal defect

Drug target

Other:

D04510

Class

Cellular Processes; Cell communication; Tight junction [PATH:hsa04530]
Organismal Systems; Circulatory system; Cardiac muscle contraction [PATH:hsa04260]
Human Diseases; Cardiovascular diseases; Hypertrophic cardiomyopathy (HCM) [PATH:hsa05410]
Human Diseases; Cardiovascular diseases; Dilated cardiomyopathy (DCM) [PATH:hsa05414]
Human Diseases; Cardiovascular diseases; Viral myocarditis [PATH:hsa05416]

SSDB

Motif

Pfam:

Myosin_tail_1 Myosin_head Myosin_N Filament Reo_sigmaC AAA_22 IQ

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

14q12

AA seq 1939 aa
MTDAQMADFGAAAQYLRKSEKERLEAQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVI
AETENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGL
FCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES
GAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRND
NSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLD
MLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHY
GNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQ
VYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN
FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECM
FPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKD
PLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKL
MTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF
RQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD
ERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKP
LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL
NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE
LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN
SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE
KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD
LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD
SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE
YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ
LEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD
AIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA
AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF
KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKI
LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKM
EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN
NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ
SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD
EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDK
KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN
KLRAKSRDIGAKQKMHDEE

NT seq 5820 nt +upstreamnt +downstreamnt
atgaccgatgcccagatggctgactttggggcagcggcccagtacctccgcaagtcagag
aaggagcgtctagaggcccagacccggccctttgacattcgcactgagtgcttcgtgccc
gatgacaaggaagagtttgtcaaagccaagattttgtcccgggagggaggcaaggtcatt
gctgaaaccgagaatgggaagacggtgactgtgaaggaggaccaggtgttgcagcagaac
ccacccaagttcgacaagattgaggacatggccatgctgaccttcctgcacgagcccgcg
gtgcttttcaacctcaaggagcgctacgcggcctggatgatatatacctactcgggcctc
ttctgtgtcactgtcaacccctacaagtggctgccggtgtacaatgccgaggtggtggcc
gcctaccggggcaagaagaggagtgaggccccgccccacatcttctccatctccgacaac
gcctatcagtacatgctgacagatcgggagaaccagtccatcctcatcacgggagaatcc
ggggcggggaagactgtgaacaccaagcgtgtcatccagtactttgccagcattgcagcc
ataggtgaccgtggcaagaaggacaatgccaatgcgaacaagggcaccctggaggaccag
atcatccaggccaaccccgctctggaggccttcggcaatgccaagactgtccggaacgac
aactcctcccgctttgggaaattcattaggatccactttggggccactggaaagctggct
tctgcagacatagagacctacctgctggagaagtcccgggtgatcttccagctgaaagct
gagagaaactaccacatcttctaccagattctgtccaacaagaagccggagttgctggac
atgctgctggtcaccaacaatccctacgactacgccttcgtgtctcagggagaggtgtcc
gtggcctccattgatgactccgaggagctcatggccaccgatagtgcctttgacgtgctg
ggcttcacttcagaggagaaagctggcgtctacaagctgacgggagccatcatgcactac
gggaacatgaagttcaagcagaagcagcgggaggagcaggcggagccagacggcaccgaa
gatgctgacaagtcggcctacctcatggggctgaactcagctgacctgctcaaggggctg
tgccaccctcgggtgaaagtgggcaacgagtatgtcaccaaggggcagagcgtgcagcag
gtgtactactccatcggggctctggccaaggcagtgtatgagaagatgttcaactggatg
gtgacgcgcatcaacgccaccctggagaccaagcagccacgccagtacttcataggagtc
ctggacatcgctggcttcgagatcttcgacttcaacagctttgagcagctctgcatcaac
ttcaccaacgagaagctgcagcagttcttcaaccaccacatgttcgtgctggagcaggag
gagtacaagaaggagggcattgagtggacattcattgactttggcatggacctgcaggcc
tgcattgacctcatcgagaagcccatgggcatcatgtccatcctggaggaggagtgcatg
ttccccaaggccactgacatgaccttcaaggccaagctgtacgacaaccacctgggcaag
tccaacaatttccagaagccacgcaacatcaaggggaagcaggaagcccacttctccctg
atccactacgccggcactgtggactacaacatcctgggctggctggaaaaaaacaaggat
cctctcaacgagactgttgtggccctgtaccagaagtcctccctcaagctcatggccact
ctcttctcctcctacgcaactgccgatactggggacagtggtaaaagcaaaggaggcaag
aaaaagggctcatccttccagacggtgtcggctctccaccgggaaaatctcaacaagcta
atgaccaacctgaggaccacccatcctcactttgtgcgttgcatcatccccaatgagcgg
aaggctccaggggtgatggacaaccccctggtcatgcaccagctgcgctgcaatggcgtg
ctggagggcatccgcatctgcaggaagggcttccccaaccgcatcctctacggggacttc
cggcagaggtatcgcatcctgaacccagtggccatccctgagggacagttcattgatagc
aggaaggggacagagaagctgctcagctctctggacattgatcacaaccagtacaagttt
ggccacaccaaggtgttcttcaaggcagggctgcttgggctgctggaggagatgcgggat
gagaggctgagccgcatcatcacgcgcatgcaggcccaagcccggggccagctcatgcgc
attgagttcaagaagatagtggaacgcagggatgccctgctggtaatccagtggaacatt
cgggccttcatgggggtcaagaattggccctggatgaagctctacttcaagatcaagccg
ctgctgaagagcgcagagacggagaaggagatggccaccatgaaggaagagttcgggcgc
atcaaagagacgctggagaagtccgaggctcgccgcaaggagctggaggagaagatggtg
tccctgctgcaggagaagaatgacctgcagctccaagtgcaggcggaacaagacaacctc
aatgatgctgaggagcgctgcgaccagctgatcaaaaacaagattcagctggaggccaaa
gtaaaggagatgaatgagaggctggaggatgaggaggagatgaacgcggagctcactgcc
aagaagcgcaagctggaagacgagtgctcagagctcaagaaggacattgatgacctggag
ctgacactggccaaggtggagaaggagaagcatgcaacagagaacaaggtgaagaaccta
acagaggagatggctgggctggatgaaatcatcgctaagctgaccaaggagaagaaagct
ctacaagaggcccatcagcaggccctggatgaccttcaggttgaggaagacaaggtcaac
agcctgtccaagtctaaggtcaagctggagcagcaggtggatgatctggagggatcccta
gagcaagagaagaaggtgcgcatggacctggagcgagcaaagcggaaactggagggcgac
ctgaagctgacccaggagagcatcatggacctggaaaatgataaactgcagctggaagaa
aagcttaagaagaaggagtttgacattaatcagcagaacagtaagattgaggatgagcag
gtgctggcccttcaactacagaagaaactgaaggaaaaccaggcacgcatcgaggagctg
gaggaggagctggaggccgagcgcaccgccagggctaaggtggagaagctgcgctcagac
ctgtctcgggagctggaggagatcagcgagcggctggaagaggccggcggggccacgtcc
gtgcagatcgagatgaacaagaagcgcgaggccgagttccagaagatgcggcgggacctg
gaggaggccacgctgcagcacgaggccactgccgcggccctgcgcaagaagcacgccgac
agcgtggccgagctgggcgagcagatcgacaacctgcagcgggtgaagcagaagctggag
aaggagaagagcgagttcaagctggagctggatgacgtcacctccaacatggagcagatc
atcaaggccaaggcaaacctggagaaagtgtctcggacgctggaggaccaggccaatgag
taccgcgtgaagctagaagaggcccaacgctccctcaatgatttcaccacccagcgagcc
aagctgcagaccgagaatggagagttggcccggcagctagaggaaaaggaggcgctaatc
tcgcagctgacccgggggaagctctcttatacccagcaaatggaggacctcaaaaggcag
ctggaggaggagggcaaggcgaagaacgccctggcccatgcactgcagtcggcccggcat
gactgcgacctgctgcgggagcagtacgaggaggagacagaggccaaggccgagctgcag
cgcgtcctgtccaaggccaactcggaggtggcccagtggaggaccaagtatgagacggac
gccattcagcggactgaggagctcgaagaggccaaaaagaagctggcccagcggctgcag
gatgccgaggaggccgtggaggctgttaatgccaagtgctcctcactggagaagaccaag
caccggctacagaatgagatagaggacttgatggtggacgtagagcgctccaatgctgct
gctgcagccctggacaagaagcagagaaactttgacaagatcctggccgagtggaagcag
aagtatgaggagtcgcagtctgagctggagtcctcacagaaggaggctcgctccctcagc
acagagctcttcaagctcaagaacgcctacgaggagtccctggagcacctagagaccttc
aagcgggagaacaagaaccttcaggaggaaatctcggaccttactgagcagctaggagaa
ggaggaaagaatgtgcatgagctggagaaggtccgcaaacagctggaggtggagaagctg
gagctgcagtcagccctggaggaggcagaggcctccctggagcacgaggagggcaagatc
ctccgggcccagctagagttcaaccagatcaaggcagagatcgagcggaagctggcagag
aaggacgaggagatggaacaggccaagcgcaaccaccagcgggtggtggactcgctgcag
acctccctggatgcagagacacgcagccgcaacgaggtcctgagggtgaagaagaagatg
gaaggagacctcaatgagatggagatccagctcagccacgccaaccgcatggctgccgag
gcccagaagcaagtcaagagcctccagagcttgctgaaggacacccagatccagctggac
gatgcggtccgtgccaacgacgacctgaaggagaacatcgccatcgtggagcggcgcaac
aacctgctgcaggctgagctggaggagctgcgtgccgtggtggagcagacagagcggtcc
cggaagctggcggagcaggagctgattgagaccagcgagcgggtgcagctgctgcattcc
cagaacaccagcctcatcaaccagaagaagaagatggagtcggatctgacccagctccag
tcggaagtggaggaggcagtgcaggagtgcagaaacgccgaggagaaggccaagaaggcc
atcacggatgccgccatgatggcagaggagctgaagaaggagcaggacaccagcgcccac
ctggagcgcatgaagaagaacatggagcagaccattaaggacctgcagcaccggctggac
gaggccgagcagatcgccctcaagggaggcaagaagcagctgcagaagctggaagcgcgg
gtgcgggagctggagggtgagctggaggccgagcagaagcgcaacgcagagtcggtgaag
ggcatgaggaagagcgagcggcgcatcaaggagctcacctaccagacagaggaagacaaa
aagaacctgctgcggctacaggacctggtggacaagctgcaactgaaggtcaaggcctac
aagcgccaggccgaggaggcggaggagcaagccaacaccaacctgtccaagttccgcaag
gtgcagcatgagctggatgaggcagaggagcgggcggacatcgctgagtcccaggtcaac
aagcttcgagccaagagccgtgacattggtgccaagcaaaaaatgcacgatgaggagtga

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (9)   
   KEGG DISEASE (3)   
   OMIM (6)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
Protein domain (7)   
   Pfam (7)   
All databases (62)   

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