KEGG   Homo sapiens (human): 477Help
Entry
477               CDS       T01001                                 

Gene name
ATP1A2, FHM2, MHP2
Definition
ATPase, Na+/K+ transporting, alpha 2 polypeptide (EC:3.6.3.9)
Orthology
K01539  
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Organism
hsa  Homo sapiens (human)
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00775  
Familial or sporadic hemiplegic migraine
H00998  
Alternating hemiplegia of childhood
Drug target
Acetyldigitoxin: 
Acetyldigoxin: 
Digitoxin: 
Digoxin: 
Lanatoside C: 
Deslanoside: 
Metildigoxin: 
Gitoformate: 
Proscillaridin: 
G-strophanthin: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    477 (ATP1A2)
   04022 cGMP - PKG signaling pathway
    477 (ATP1A2)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    477 (ATP1A2)
   04918 Thyroid hormone synthesis
    477 (ATP1A2)
   04919 Thyroid hormone signaling pathway
    477 (ATP1A2)
  Circulatory system
   04260 Cardiac muscle contraction
    477 (ATP1A2)
   04261 Adrenergic signaling in cardiomyocytes
    477 (ATP1A2)
  Digestive system
   04970 Salivary secretion
    477 (ATP1A2)
   04971 Gastric acid secretion
    477 (ATP1A2)
   04972 Pancreatic secretion
    477 (ATP1A2)
   04976 Bile secretion
    477 (ATP1A2)
   04973 Carbohydrate digestion and absorption
    477 (ATP1A2)
   04974 Protein digestion and absorption
    477 (ATP1A2)
   04978 Mineral absorption
    477 (ATP1A2)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477 (ATP1A2)
   04961 Endocrine and other factor-regulated calcium reabsorption
    477 (ATP1A2)
   04964 Proximal tubule bicarbonate reclamation
    477 (ATP1A2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     477 (ATP1A2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   477 (ATP1A2)
  Exosomal proteins of other body fluids (saliva and urine)
   477 (ATP1A2)
  Exosomal proteins of colorectal cancer cells
   477 (ATP1A2)
  Exosomal proteins of bladder cancer cells
   477 (ATP1A2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
1q23.2
AA seq 1020 aa AA seqDB search
MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM
ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
NT seq 3063 nt NT seq  +upstreamnt  +downstreamnt
atgggccgtggggctggccgtgagtactcacctgccgccaccacggcagagaatgggggc
ggcaagaagaaacagaaggagaaggaactggatgagctgaagaaggaggtggcaatggat
gaccacaagctgtccttggatgagctgggccgcaaataccaagtggacctgtccaagggc
ctcaccaaccagcgggctcaggacgttctggctcgagatgggcccaacgccctcacacca
cctcccacaacccctgagtgggtcaagttctgccgtcagcttttcggggggttctccatc
ctgctgtggattggggctatcctctgcttcctggcctacggcatccaggctgccatggag
gatgaaccatccaacgacaatctatatctgggtgtggtgctggcagctgtggtcattgtc
actggctgcttctcctactaccaggaggccaagagctccaagatcatggattccttcaag
aacatggtacctcagcaagcccttgtgatccgggagggagagaagatgcagatcaacgca
gaggaagtggtggtgggagacctggtggaggtgaagggtggagaccgcgtccctgctgac
ctccggatcatctcttctcatggctgtaaggtggataactcatccttaacaggagagtcg
gagccccagacccgctcccccgagttcacccatgagaaccccctggagacccgcaatatc
tgtttcttctccaccaactgtgttgaaggcactgccaggggcattgtgattgccacagga
gaccggacggtgatgggccgcatagctactctcgcctcaggcctggaggttgggcggaca
cccatagcaatggagattgaacacttcatccagctgatcacaggggtcgctgtattcctg
ggggtctccttcttcgtgctctccctcatcctgggctacagctggctggaggcagtcatc
ttcctcatcggcatcatagtggccaacgtgcctgaggggcttctggccactgtcactgtg
tgcctgaccctgacagccaagcgcatggcacggaagaactgcctggtgaagaacctggag
gcggtggagacgctgggctccacgtccaccatctgctcggacaagacgggcaccctcacc
cagaaccgcatgaccgtcgcccacatgtggttcgacaaccaaatccatgaggctgacacc
accgaagatcagtctggggccacttttgacaaacgatcccctacgtggacggccctgtct
cgaattgctggtctctgcaaccgcgccgtcttcaaggcaggacaggagaacatctccgtg
tctaagcgggacacagctggtgatgcctctgagtcagctctgctcaagtgcattgagctc
tcctgtggctcagtgaggaaaatgagagacagaaaccccaaggtggcagagattcctttc
aactctaccaacaagtaccagctgtctatccacgagcgagaagacagcccccagagccac
gtgctggtgatgaagggggccccagagcgcattctggaccggtgctccaccatcctggtg
cagggcaaggagatcccgctcgacaaggagatgcaagatgcctttcaaaatgcctacatg
gagctggggggacttggggagcgtgtgctgggattctgtcaactgaatctgccatctgga
aagtttcctcggggcttcaaattcgacacggatgagctgaactttcccacggagaagctt
tgctttgtggggctcatgtctatgattgaccctccccgggctgctgtgccagatgctgtg
ggcaagtgccgaagcgcaggcatcaaggtgatcatggtaaccggggatcaccctatcaca
gccaaggccattgccaaaggcgtgggcatcatatcagagggtaacgagactgtggaggac
attgcagcccggctcaacattcccatgagtcaagtcaaccccagagaagccaaggcatgc
gtggtgcacggctctgacctgaaggacatgacatcggagcagctcgatgagatcctcaag
aaccacacagagatcgtctttgctcgaacgtctccccagcagaagctcatcattgtggag
ggatgtcagaggcagggagccattgtggccgtgacgggtgacggggtgaacgactcccct
gcattgaagaaggctgacattggcattgccatgggcatctctggctctgacgtctctaag
caggcagccgacatgatcctgctggatgacaactttgcctccatcgtcacgggggtggag
gagggccgcctgatctttgacaacttgaagaaatccatcgcctacaccctgaccagcaac
atccccgagatcacccccttcctgctgttcatcattgccaacatccccctacctctgggc
actgtgaccatcctttgcattgacctgggcacagatatggtccctgccatctccttggcc
tatgaggcagctgagagtgatatcatgaagcggcagccacgaaactcccagacggacaag
ctggtgaatgagaggctcatcagcatggcctacggacagatcgggatgatccaggcactg
ggtggcttcttcacctactttgtgatcctggcagagaacggtttcctgccatcacggcta
ctgggaatccgcctcgactgggatgaccggaccatgaatgatctggaggacagctatgga
caggagtggacctatgagcagcggaaggtggtggagttcacgtgccacacggcattcttt
gccagcatcgtggtggtgcagtgggctgacctcatcatctgcaagacccgccgcaactca
gtcttccagcagggcatgaagaacaagatcctgatttttgggctcctggaggagacggcg
ttggctgcctttctctcttactgcccaggcatgggtgtagccctccgcatgtacccgctc
aaagtcacctggtggttctgcgccttcccctacagcctcctcatcttcatctatgatgag
gtccgaaagctcatcctgcggcggtatcctggtggctgggtggagaaggagacatactac
tga

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