KEGG   Homo sapiens (human): 478Help
Entry
478               CDS       T01001                                 

Gene name
ATP1A3, AHC2, DYT12, RDP
Definition
ATPase, Na+/K+ transporting, alpha 3 polypeptide (EC:3.6.3.9)
Orthology
K01539  
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Organism
hsa  Homo sapiens (human)
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00831  
Primary dystonia
Drug target
Acetyldigitoxin: 
Acetyldigoxin: 
Digitoxin: 
Digoxin: 
Lanatoside C: 
Deslanoside: 
Metildigoxin: 
Gitoformate: 
Proscillaridin: 
G-strophanthin: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    478 (ATP1A3)
   04022 cGMP - PKG signaling pathway
    478 (ATP1A3)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    478 (ATP1A3)
   04918 Thyroid hormone synthesis
    478 (ATP1A3)
   04919 Thyroid hormone signaling pathway
    478 (ATP1A3)
  Circulatory system
   04260 Cardiac muscle contraction
    478 (ATP1A3)
   04261 Adrenergic signaling in cardiomyocytes
    478 (ATP1A3)
  Digestive system
   04970 Salivary secretion
    478 (ATP1A3)
   04971 Gastric acid secretion
    478 (ATP1A3)
   04972 Pancreatic secretion
    478 (ATP1A3)
   04976 Bile secretion
    478 (ATP1A3)
   04973 Carbohydrate digestion and absorption
    478 (ATP1A3)
   04974 Protein digestion and absorption
    478 (ATP1A3)
   04978 Mineral absorption
    478 (ATP1A3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    478 (ATP1A3)
   04961 Endocrine and other factor-regulated calcium reabsorption
    478 (ATP1A3)
   04964 Proximal tubule bicarbonate reclamation
    478 (ATP1A3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     478 (ATP1A3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   478 (ATP1A3)
  Exosomal proteins of other body fluids (saliva and urine)
   478 (ATP1A3)
  Exosomal proteins of colorectal cancer cells
   478 (ATP1A3)
  Exosomal proteins of bladder cancer cells
   478 (ATP1A3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
19q13.31
AA seq 1024 aa AA seqDB search
MGGWEEERNRRATDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDC
VQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQA
GTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQ
VNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLET
RNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVA
VFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVK
NLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWV
ALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAE
IPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQ
NAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAV
PDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRD
AKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGV
NDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYT
LTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNP
RTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLE
DSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLF
EETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEK
ETYY
NT seq 3075 nt NT seq  +upstreamnt  +downstreamnt
atgggaggctgggaggaggagaggaacaggagagccacggacaagaaagatgacaaggac
tcacccaagaagaacaagggcaaggagcgccgggacctggatgacctcaagaaggaggtg
gctatgacagagcacaagatgtcagtggaagaggtctgccggaaatacaacacagactgt
gtgcagggtttgacccacagcaaagcccaggagatcctggcccgggatgggcctaacgca
ctcacgccaccgcctaccaccccagagtgggtcaagttttgccggcagctcttcgggggc
ttctccatcctgctgtggatcggggctatcctctgcttcctggcctacggtatccaggcg
ggcaccgaggacgacccctctggtgacaacctgtacctgggcatcgtgctggcggccgtg
gtgatcatcactggctgcttctcctactaccaggaggccaagagctccaagatcatggag
tccttcaagaacatggtgccccagcaagccctggtgatccgggaaggtgagaagatgcag
gtgaacgctgaggaggtggtggtcggggacctggtggagatcaagggtggagaccgagtg
ccagctgacctgcggatcatctcagcccacggctgcaaggtggacaactcctccctgact
ggcgaatccgagccccagactcgctctcccgactgcactcacgacaaccccttggagact
cggaacatcaccttcttttccaccaactgtgtggaaggcacggctcggggcgtggtggtg
gccacgggcgaccgcactgtcatgggccgtatcgccaccctggcatcagggctggaggtg
ggcaagacgcccatcgccatcgagattgagcacttcatccagctcatcaccggcgtggct
gtcttcctgggtgtctccttcttcatcctctccctcattctcggatacacctggcttgag
gctgtcatcttcctcatcggcatcatcgtggccaatgtcccagagggtctgctggccact
gtcactgtgtgtctgacgctgaccgccaagcgcatggcccggaagaactgcctggtgaag
aacctggaggctgtagaaaccctgggctccacgtccaccatctgctcagataagacaggg
accctcactcagaaccgcatgacagtcgcccacatgtggtttgacaaccagatccacgag
gctgacaccactgaggaccagtcagggacctcatttgacaagagttcgcacacctgggtg
gccctgtctcacatcgctgggctctgcaatcgcgctgtcttcaagggtggtcaggacaac
atccctgtgctcaagagggatgtggctggggatgcgtctgagtctgccctgctcaagtgc
atcgagctgtcctctggctccgtgaagctgatgcgtgaacgcaacaagaaagtggctgag
attcccttcaattccaccaacaaataccagctctccatccatgagaccgaggaccccaac
gacaaccgatacctgctggtgatgaagggtgcccccgagcgcatcctggaccgctgctcc
accatcctgctacagggcaaggagcagcctctggacgaggaaatgaaggaggccttccag
aatgcctaccttgagctcggtggcctgggcgagcgcgtgcttggtttctgccattattac
ctgcccgaggagcagttccccaagggctttgccttcgactgtgatgacgtgaacttcacc
acggacaacctctgctttgtgggcctcatgtccatgatcgacccaccccgggcagccgtc
cctgacgcggtgggcaagtgtcgcagcgcaggcatcaaggtcatcatggtcaccggcgat
caccccatcacggccaaggccattgccaagggtgtgggcatcatctctgagggcaacgag
actgtggaggacatcgccgcccggctcaacattcccgtcagccaggttaacccccgggat
gccaaggcctgcgtgatccacggcaccgacctcaaggacttcacctccgagcaaatcgac
gagatcctgcagaatcacaccgagatcgtcttcgcccgcacatccccccagcagaagctc
atcattgtggagggctgtcagagacagggtgcaattgtggctgtgaccggggatggtgtg
aacgactcccccgctctgaagaaggccgacattggggtggccatgggcatcgctggctct
gacgtctccaagcaggcagctgacatgatcctgctggacgacaactttgcctccatcgtc
acaggggtggaggagggccgcctgatcttcgacaacctaaagaagtccattgcctacacc
ctgaccagcaatatcccggagatcacgcccttcctgctgttcatcatggccaacatcccg
ctgcccctgggcaccatcaccatcctctgcatcgatctgggcactgacatggtccctgcc
atctcactggcgtacgaggctgccgaaagcgacatcatgaagagacagcccaggaacccg
cggacggacaaattggtcaatgagagactcatcagcatggcctacgggcagattggaatg
atccaggctctcggtggcttcttctcttactttgtgatcctggcagaaaatggcttcttg
cccggcaacctggtgggcatccggctgaactgggatgaccgcaccgtcaatgacctggaa
gacagttacgggcagcagtggacatacgagcagaggaaggtggtggagttcacctgccac
acggccttctttgtgagcatcgttgtcgtccagtgggccgatctgatcatctgcaagacc
cggaggaactcggtcttccagcagggcatgaagaacaagatcctgatcttcgggctgttt
gaggagacggccctggctgccttcctgtcctactgccccggcatggacgtggccctgcgc
atgtaccctctcaagcccagctggtggttctgtgccttcccctacagtttcctcatcttc
gtctacgacgaaatccgcaaactcatcctgcgcaggaacccagggggttgggtggagaag
gaaacctactactga

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