KEGG   Homo sapiens (human): 489
Entry
489               CDS       T01001                                 
Symbol
ATP2A3, SERCA3
Name
(RefSeq) ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
  KO
K05853  P-type Ca2+ transporter type 2A [EC:7.2.2.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04148  Efferocytosis
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04380  Osteoclast differentiation
hsa04919  Thyroid hormone signaling pathway
hsa04972  Pancreatic secretion
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05415  Diabetic cardiomyopathy
Network
nt06528  Calcium signaling
  Element
N01645  Cytosolic Ca2+ removal, SERCA
N01646  Regulation of SERCA
Drug target
Mipsagargin: D10715
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    489 (ATP2A3)
   04024 cAMP signaling pathway
    489 (ATP2A3)
   04022 cGMP-PKG signaling pathway
    489 (ATP2A3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    489 (ATP2A3)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    489 (ATP2A3)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    489 (ATP2A3)
   04261 Adrenergic signaling in cardiomyocytes
    489 (ATP2A3)
  09154 Digestive system
   04972 Pancreatic secretion
    489 (ATP2A3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    489 (ATP2A3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    489 (ATP2A3)
   05017 Spinocerebellar ataxia
    489 (ATP2A3)
   05022 Pathways of neurodegeneration - multiple diseases
    489 (ATP2A3)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    489 (ATP2A3)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    489 (ATP2A3)
   05414 Dilated cardiomyopathy
    489 (ATP2A3)
   05415 Diabetic cardiomyopathy
    489 (ATP2A3)
Enzymes [BR:hsa01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.10  P-type Ca2+ transporter
     489 (ATP2A3)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD DUF3106
Other DBs
NCBI-GeneID: 489
NCBI-ProteinID: NP_005164
OMIM: 601929
HGNC: 813
Ensembl: ENSG00000074370
UniProt: Q93084 A8K9K1
Position
17:complement(3923873..3964437)
AA seq 999 aa
MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDL
LVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK
EYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSIL
TGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC
NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPT
SREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGML
DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDD
LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI
GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMA
LSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK
NT seq 3000 nt   +upstreamnt  +downstreamnt
atggaggcggcgcatctgctcccggccgccgacgtgctgcgccacttctcggtgacagcc
gagggcggcctgagcccggcgcaggtgaccggcgcgcgggagcgctacggccccaacgag
ctcccgagtgaggaagggaagtccctgtgggagctggtgctggaacagtttgaggacctc
ctggtgcgcatcctgctgctggctgcccttgtctcctttgtcctggcctggttcgaggag
ggcgaggagaccacgaccgccttcgtggagcccctggtcatcatgctgatcctcgtggcc
aacgccattgtgggcgtgtggcaggaacgcaacgccgagagtgccatcgaggccctgaag
gagtatgagcctgagatgggcaaggtgatccgctcggaccgcaagggcgtgcagaggatc
cgtgcccgggacatcgtcccaggggacattgtagaagtggcagtgggggacaaagtgcct
gctgacctccgcctcatcgagatcaagtccaccacgctgcgagtggaccagtccatcctg
acgggtgaatctgtgtccgtgaccaagcacacagaggccatcccagaccccagagctgtg
aaccaggacaagaagaacatgctgttttctggcaccaatatcacatcgggcaaagcggtg
ggtgtggccgtggccaccggcctgcacacggagctgggcaagatccggagccagatggcg
gcagtcgagcccgagcggacgccgctgcagcgcaagctggacgagtttggacggcagctg
tcccacgccatctctgtgatctgcgtggccgtgtgggtcatcaacatcggccacttcgcc
gacccggcccacggtggctcctggctgcgtggcgctgtctactacttcaagatcgccgtg
gccctggcggtggcggccatccccgagggcctcccggctgtcatcactacatgcctggca
ctgggcacgcggcgcatggcacgcaagaacgccatcgtgcgaagcctgccgtccgtggag
accctgggctgcacctcagtcatctgctccgacaagacgggcacgctcaccaccaatcag
atgtctgtctgccggatgttcgtggtagccgaggccgatgcgggctcctgccttttgcac
gagttcaccatctcgggtaccacgtatacccccgagggcgaagtgcggcagggggatcag
cctgtgcgctgcggccagttcgacgggctggtggagctggcgaccatctgcgccctgtgc
aacgactcggctctggactacaacgaggccaagggtgtgtatgagaaggtgggagaggcc
acggagacagctctgacttgcctggtggagaagatgaacgtgttcgacaccgacctgcag
gctctgtcccgggtggagcgagctggcgcctgtaacacggtcatcaagcagctgatgcgg
aaggagttcaccctggagttctcccgagaccggaaatccatgtccgtgtactgcacgccc
acccgccctcaccctactggccagggcagcaagatgtttgtgaagggggctcctgagagt
gtgatcgagcgctgtagctcagtccgcgtggggagccgcacagcacccctgacccccacc
tccagggagcagatcctggcaaagatccgggattggggctcaggctcagacacgctgcgc
tgcctggcactggccacccgggacgcgcccccaaggaaggaggacatggagctggacgac
tgcagcaagtttgtgcagtacgagacggacctgaccttcgtgggctgcgtaggcatgctg
gacccgccgcgacctgaggtggctgcctgcatcacacgctgctaccaggcgggcatccgc
gtggtcatgatcacgggggataacaaaggcactgccgtggccatctgccgcaggcttggc
atctttggggacacggaagacgtggcgggcaaggcctacacgggccgcgagtttgatgac
ctcagccccgagcagcagcgccaggcctgccgcaccgcccgctgcttcgcccgcgtggag
cccgcacacaagtcccgcatcgtggagaacctgcagtcctttaacgagatcactgctatg
actggcgatggagtgaacgacgcaccagccctgaagaaagcagagatcggcatcgccatg
ggctcaggcacggccgtggccaagtcggcggcagagatggtgctgtcagatgacaacttt
gcctccatcgtggctgcggtggaggagggccgggccatctacagcaacatgaagcaattc
atccgctacctcatctcctccaatgttggcgaggtcgtctgcatcttcctcacggcaatt
ctgggcctgcccgaagccctgatccctgtgcagctgctctgggtgaacctggtgacagac
ggcctacctgccacggctctgggcttcaacccgccagacctggacatcatggagaagctg
ccccggagcccccgagaagccctcatcagtggctggctcttcttccgatacctggctatc
ggagtgtacgtaggcctggccacagtggctgccgccacctggtggtttgtgtatgacgcc
gagggacctcacatcaacttctaccagctgaggaacttcctgaagtgctccgaagacaac
ccgctctttgccggcatcgactgtgaggtgttcgagtcacgcttccccaccaccatggcc
ttgtccgtgctcgtgaccattgaaatgtgcaatgccctcaacagcgtctcggagaaccag
tcgctgctgcggatgccgccctggatgaacccctggctgctggtggctgtggccatgtcc
atggccctgcacttcctcatcctgctcgtgccgcccctgcctctcattttccaggtgacc
ccactgagcgggcgccagtgggtggtggtgctccagatatctctgcctgtcatcctgctg
gatgaggccctcaagtacctgtcccggaaccacatgcacgaagaaatgagccagaagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (16)   
   KEGG PATHWAY (16)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (32)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (29)   
DNA sequence (49)   
   RefSeq(nuc) (29)   
   GenBank (10)   
   EMBL (10)   
Protein domain (8)   
   Pfam (8)   
All databases (127)   

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