KEGG T01001: 4914

Homo sapiens (human): 4914

Entry

4914 CDS T01001

Gene name

NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Definition

neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1)

Orthology

K03176

neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010	MAPK signaling pathway
hsa04144	Endocytosis
hsa04210	Apoptosis
hsa04722	Neurotrophin signaling pathway
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05216	Thyroid cancer

Disease

H00032	Thyroid cancer
H00043	Neuroblastoma

Drug target

Other:

D04696

Class

Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:hsa04010]
Cellular Processes; Transport and catabolism; Endocytosis [PATH:hsa04144]
Cellular Processes; Cell growth and death; Apoptosis [PATH:hsa04210]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:hsa04722]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH:hsa05202]
Human Diseases; Cancers; Thyroid cancer [PATH:hsa05216]

SSDB

Motif

Pfam:

Pkinase_Tyr Pkinase I-set LRR_8 Ig_2 LRR_4

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1WWW 4F0I 4GT5 1WWA 4AOJ 2IFG 1HE7

Position

1q21-q22

AA seq 760 aa
MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAASYIENQQHLQHLELRDLRGL
GELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL
HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDD
VLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAEND
VGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT
EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDP
IPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL
APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWEL
GEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFF
GVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA
GMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP
ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEV
YAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

NT seq 2283 nt +upstreamnt +downstreamnt
atgaaggaggccgccctcatctgcctggcaccctctgtacccccgatcttgacggtgaag
tcctgggacaccatgcagttgcgggctgctagatctcggtgcacaaacttgttggcagca
agctacatcgagaaccagcagcatctgcagcatctggagctccgtgatctgaggggcctg
ggggagctgagaaacctcaccatcgtgaagagtggtctccgtttcgtggcgccagatgcc
ttccatttcactcctcggctcagtcgcctgaatctctccttcaacgctctggagtctctc
tcctggaaaactgtgcagggcctctccttacaggaactggtcctgtcggggaaccctctg
cactgttcttgtgccctgcgctggctacagcgctgggaggaggagggactgggcggagtg
cctgaacagaagctgcagtgtcatgggcaagggcccctggcccacatgcccaatgccagc
tgtggtgtgcccacgctgaaggtccaggtgcccaatgcctcggtggatgtgggggacgac
gtgctgctgcggtgccaggtggaggggcggggcctggagcaggccggctggatcctcaca
gagctggagcagtcagccacggtgatgaaatctgggggtctgccatccctggggctgacc
ctggccaatgtcaccagtgacctcaacaggaagaacgtgacgtgctgggcagagaacgat
gtgggccgggcagaggtctctgttcaggtcaacgtctccttcccggccagtgtgcagctg
cacacggcggtggagatgcaccactggtgcatccccttctctgtggatgggcagccggca
ccgtctctgcgctggctcttcaatggctccgtgctcaatgagaccagcttcatcttcact
gagttcctggagccggcagccaatgagaccgtgcggcacgggtgtctgcgcctcaaccag
cccacccacgtcaacaacggcaactacacgctgctggctgccaaccccttcggccaggcc
tccgcctccatcatggctgccttcatggacaaccctttcgagttcaaccccgaggacccc
atccctgacactaacagcacatctggagacccggtggagaagaaggacgaaacacctttt
ggggtctcggtggctgtgggcctggccgtctttgcctgcctcttcctttctacgctgctc
cttgtgctcaacaaatgtggacggagaaacaagtttgggatcaaccgcccggctgtgctg
gctccagaggatgggctggccatgtccctgcatttcatgacattgggtggcagctccctg
tcccccaccgagggcaaaggctctgggctccaaggccacatcatcgagaacccacaatac
ttcagtgatgcctgtgttcaccacatcaagcgccgggacatcgtgctcaagtgggagctg
ggggagggcgcctttgggaaggtcttccttgctgagtgccacaacctcctgcctgagcag
gacaagatgctggtggctgtcaaggcactgaaggaggcgtccgagagtgctcggcaggac
ttccagcgtgaggctgagctgctcaccatgctgcagcaccagcacatcgtgcgcttcttc
ggcgtctgcaccgagggccgccccctgctcatggtctttgagtatatgcggcacggggac
ctcaaccgcttcctccgatcccatggacctgatgccaagctgctggctggtggggaggat
gtggctccaggccccctgggtctggggcagctgctggccgtggctagccaggtcgctgcg
gggatggtgtacctggcgggtctgcattttgtgcaccgggacctggccacacgcaactgt
ctagtgggccagggactggtggtcaagattggtgattttggcatgagcagggatatctac
agcaccgactattaccgtgtgggaggccgcaccatgctgcccattcgctggatgccgccc
gagagcatcctgtaccgtaagttcaccaccgagagcgacgtgtggagcttcggcgtggtg
ctctgggagatcttcacctacggcaagcagccctggtaccagctctccaacacggaggca
atcgactgcatcacgcagggacgtgagttggagcggccacgtgcctgcccaccagaggtc
tacgccatcatgcggggctgctggcagcgggagccccagcaacgccacagcatcaaggat
gtgcacgcccggctgcaagccctggcccaggcacctcctgtctacctggatgtcctgggc
tag

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (7)   
   PDB (7)   
Protein domain (6)   
   Pfam (6)   
All databases (70)   

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