KEGG   Homo sapiens (human): 4939
Entry
4939              CDS       T01001                                 
Symbol
OAS2
Name
(RefSeq) 2'-5'-oligoadenylate synthetase 2
  KO
K14216  2'-5'-oligoadenylate synthetase [EC:2.7.7.84]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa05160  Hepatitis C
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06163  Hepatitis C virus (HCV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06263  Hepatocellular carcinoma
nt06521  NLR signaling
  Element
N00273  HCV NS5A to oligoadenylate synthetase (OAS)/RNase L pathway
N00515  Oligoadenylate synthetase (OAS)/RNase L pathway
N00574  HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway
N00724  IAV NS1 to oligoadenylate synthetase (OAS)/RNase L pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    4939 (OAS2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    4939 (OAS2)
   05171 Coronavirus disease - COVID-19
    4939 (OAS2)
   05164 Influenza A
    4939 (OAS2)
   05162 Measles
    4939 (OAS2)
   05168 Herpes simplex virus 1 infection
    4939 (OAS2)
   05169 Epstein-Barr virus infection
    4939 (OAS2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.84  2'-5' oligoadenylate synthase
     4939 (OAS2)
SSDB
Motif
Pfam: OAS1_C NTP_transf_2 SMODS DZF_N
Other DBs
NCBI-GeneID: 4939
NCBI-ProteinID: NP_058197
OMIM: 603350
HGNC: 8087
Ensembl: ENSG00000111335
UniProt: P29728
Position
12:112978519..113011723
AA seq 719 aa
MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIG
GSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEI
QKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVC
FTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKD
NFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNN
VSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNK
CFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKS
YTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSF
DVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLK
DLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVT
QYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEA
KEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF
NT seq 2160 nt   +upstreamnt  +downstreamnt
atgggaaatggggagtcccagctgtcctcggtgcctgctcagaagctgggttggtttatc
caggaatacctgaagccctacgaagaatgtcagacactgatcgacgagatggtgaacacc
atctgtgacgtcctgcaggaacccgaacagttccccctggtgcagggagtggccataggt
ggctcctatggacggaaaacagtcttaagaggcaactccgatggtacccttgtcctcttc
ttcagtgacttaaaacaattccaggatcagaagagaagccaacgtgacatcctcgataaa
actggggataagctgaagttctgtctgttcacgaagtggttgaaaaacaatttcgagatc
cagaagtcccttgatgggttcaccatccaggtgttcacaaaaaatcagagaatctctttc
gaggtgctggccgccttcaacgctctgagcttaaatgataatcccagcccctggatctat
cgagagctcaaaagatccttggataagacaaatgccagtcctggtgagtttgcagtctgc
ttcactgaactccagcagaagttttttgacaaccgtcctggaaaactaaaggatttgatc
ctcttgataaagcactggcatcaacagtgccagaaaaaaatcaaggatttaccctcgctg
tctccgtatgccctggagctgcttacggtgtatgcctgggaacaggggtgcagaaaagac
aactttgacattgctgaaggcgtcagaaccgtactggagctgatcaaatgccaggagaag
ctgtgtatctattggatggtcaactacaactttgaagatgagaccatcaggaacatcctg
ctgcaccagctccaatcagcgaggccagtaatcttggatccagttgacccaaccaataat
gtgagtggagataaaatatgctggcaatggctgaaaaaagaagctcaaacctggttgact
tctcccaacctggataatgagttacctgcaccatcttggaatgttctgcctgcaccactc
ttcacgaccccaggccaccttctggataagttcatcaaggagtttctccagcccaacaaa
tgcttcctagagcagattgacagtgctgttaacatcatccgtacattccttaaagaaaac
tgcttccgacaatcaacagccaagatccagattgtccggggaggatcaaccgccaaaggc
acagctctgaagactggctctgatgccgatctcgtcgtgttccataactcacttaaaagc
tacacctcccaaaaaaacgagcggcacaaaatcgtcaaggaaatccatgaacagctgaaa
gccttttggagggagaaggaggaggagcttgaagtcagctttgagcctcccaagtggaag
gctcccagggtgctgagcttctctctgaaatccaaagtcctcaacgaaagtgtcagcttt
gatgtgcttcctgcctttaatgcactgggtcagctgagttctggctccacacccagcccc
gaggtttatgcagggctcattgatctgtataaatcctcggacctcccgggaggagagttt
tctacctgtttcacagtcctgcagcgaaacttcattcgctcccggcccaccaaactaaag
gatttaattcgcctggtgaagcactggtacaaagagtgtgaaaggaaactgaagccaaag
gggtctttgcccccaaagtatgccttggagctgctcaccatctatgcctgggagcagggg
agtggagtgccggattttgacactgcagaaggtttccggacagtcctggagctggtcaca
caatatcagcagctctgcatcttctggaaggtcaattacaactttgaagatgagaccgtg
aggaagtttctactgagccagttgcagaaaaccaggcctgtgatcttggacccagccgaa
cccacaggtgacgtgggtggaggggaccgttggtgttggcatcttctggcaaaagaagca
aaggaatggttatcctctccctgcttcaaggatgggactggaaacccaataccaccttgg
aaagtgccgacaatgcagacaccaggaagttgtggagctaggatccatcctattgtcaat
gagatgttctcatccagaagccatagaatcctgaataataattctaaaagaaacttctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (9)   
   KEGG NETWORK (9)   
Disease (1)   
   OMIM (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (27)   
   RefSeq(nuc) (3)   
   GenBank (12)   
   EMBL (12)   
Protein domain (4)   
   Pfam (4)   
All databases (87)   

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