KEGG   Homo sapiens (human): 4940
Entry
4940              CDS       T01001                                 
Symbol
OAS3, p100, p100OAS
Name
(RefSeq) 2'-5'-oligoadenylate synthetase 3
  KO
K14216  2'-5'-oligoadenylate synthetase [EC:2.7.7.84]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa05160  Hepatitis C
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06163  Hepatitis C virus (HCV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06263  Hepatocellular carcinoma
nt06521  NLR signaling
  Element
N00273  HCV NS5A to oligoadenylate synthetase (OAS)/RNase L pathway
N00515  Oligoadenylate synthetase (OAS)/RNase L pathway
N00574  HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway
N00724  IAV NS1 to oligoadenylate synthetase (OAS)/RNase L pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    4940 (OAS3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    4940 (OAS3)
   05171 Coronavirus disease - COVID-19
    4940 (OAS3)
   05164 Influenza A
    4940 (OAS3)
   05162 Measles
    4940 (OAS3)
   05168 Herpes simplex virus 1 infection
    4940 (OAS3)
   05169 Epstein-Barr virus infection
    4940 (OAS3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.84  2'-5' oligoadenylate synthase
     4940 (OAS3)
SSDB
Motif
Pfam: OAS1_C NTP_transf_2 SMODS
Other DBs
NCBI-GeneID: 4940
NCBI-ProteinID: NP_006178
OMIM: 603351
HGNC: 8088
Ensembl: ENSG00000111331
UniProt: Q9Y6K5
Structure
Position
12:112938474..112973251
AA seq 1087 aa
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG
GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF
PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH
AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG
CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD
PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD
PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI
QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL
NCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW
TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN
LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG
LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA
AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI
CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII
SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV
SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS
KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD
KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP
WPVKAAV
NT seq 3264 nt   +upstreamnt  +downstreamnt
atggacttgtacagcaccccggccgctgcgctggacaggttcgtggccagaaggctgcag
ccgcggaaggagttcgtagagaaggcgcggcgcgctctgggcgccctggccgctgccctg
agggagcgcgggggccgcctcggtgctgctgccccgcgggtgctgaaaactgtcaaggga
ggctcctcgggccggggcacagctctcaagggtggctgtgattctgaacttgtcatcttc
ctcgactgcttcaagagctatgtggaccagagggcccgccgtgcagagatcctcagtgag
atgcgggcatcgctggaatcctggtggcagaacccagtccctggtctgagactcacgttt
cctgagcagagcgtgcctggggccctgcagttccgcctgacatccgtagatcttgaggac
tggatggatgttagcctggtgcctgccttcaatgtcctgggtcaggccggctccggcgtc
aaacccaagccacaagtctactctaccctcctcaacagtggctgccaagggggcgagcat
gcggcctgcttcacagagctgcggaggaactttgtgaacattcgcccagccaagttgaag
aacctaatcttgctggtgaagcactggtaccaccaggtgtgcctacaggggttgtggaag
gagacgctgcccccggtctatgccctggaattgctgaccatcttcgcctgggagcagggc
tgtaagaaggatgctttcagcctagccgaaggcctccgaactgtcctgggcctgatccaa
cagcatcagcacctgtgtgttttctggactgtcaactatggcttcgaggaccctgcagtt
gggcagttcttgcagcggcagcttaagagacccaggcctgtgatcctggacccagctgac
cccacatgggacctggggaatggggcagcctggcactgggatttgctagcccaggaggca
gcatcctgctatgaccacccatgctttctgagggggatgggggacccagtgcagtcttgg
aaggggccgggccttccacgtgctggatgctcaggtttgggccaccccatccagctagac
cctaaccagaagacccctgaaaacagcaagagcctcaatgctgtgtacccaagagcaggg
agcaaacctccctcatgcccagctcctggccccactggggcagccagcatcgtcccctct
gtgccgggaatggccttggacctgtctcagatccccaccaaggagctggaccgcttcatc
caggaccacctgaagccgagcccccagttccaggagcaggtgaaaaaggccattgacatc
atcttgcgctgcctccatgagaactgtgttcacaaggcctcaagagtcagtaaagggggc
tcatttggccggggcacagacctaagggatggctgtgatgttgaactcatcatcttcctc
aactgcttcacggactacaaggaccaggggccccgccgcgcagagatccttgatgagatg
cgagcgcagctagaatcctggtggcaggaccaggtgcccagcctgagccttcagtttcct
gagcagaatgtgcctgaggctctgcagttccagctggtgtccacagccctgaagagctgg
acggatgttagcctgctgcctgccttcgatgctgtggggcagctcagttctggcaccaaa
ccaaatccccaggtctactcgaggctcctcaccagtggctgccaggagggcgagcataag
gcctgcttcgcagagctgcggaggaacttcatgaacattcgccctgtcaagctgaagaac
ctgattctgctggtgaagcactggtaccgccaggttgcggctcagaacaaaggaaaagga
ccagcccctgcctctctgcccccagcctatgccctggagctcctcaccatctttgcctgg
gagcagggctgcaggcaggattgtttcaacatggcccaaggcttccggacggtgctgggg
ctcgtgcaacagcatcagcagctctgtgtctactggacggtcaactatagcactgaggac
ccagccatgagaatgcaccttcttggccagcttcgaaaacccagacccctggtcctggac
cccgctgatcccacctggaacgtgggccacggtagctgggagctgttggcccaggaagca
gcagcgctggggatgcaggcctgctttctgagtagagacgggacatctgtgcagccctgg
gatgtgatgccagccctcctttaccaaaccccagctggggaccttgacaagttcatcagt
gaatttctccagcccaaccgccagttcctggcccaggtgaacaaggccgttgataccatc
tgttcatttttgaaggaaaactgcttccggaattctcccatcaaagtgatcaaggtggtc
aagggtggctcttcagccaaaggcacagctctgcgaggccgctcagatgccgacctcgtg
gtgttcctcagctgcttcagccagttcactgagcagggcaacaagcgggccgagatcatc
tccgagatccgagcccagctggaggcatgtcaacaggagcggcagttcgaggtcaagttt
gaagtctccaaatgggagaatccccgcgtgctgagcttctcactgacatcccagacgatg
ctggaccagagtgtggactttgatgtgctgccagcctttgacgccctaggccagctggtc
tctggctccaggcccagctctcaagtctacgtcgacctcatccacagctacagcaatgcg
ggcgagtactccacctgcttcacagagctacaacgggacttcatcatctctcgccctacc
aagctgaagagcctgatccggctggtgaagcactggtaccagcagtgtaccaagatctcc
aaggggagaggctccctacccccacagcacgggctggaactcctgactgtgtatgcctgg
gagcagggcgggaaggactcccagttcaacatggctgagggcttccgcacggtcctggag
ctggtcacccagtaccgccagctctgtatctactggaccatcaactacaacgccaaggac
aagactgttggagacttcctgaaacagcagcttcagaagcccaggcctatcatcctggat
ccggctgacccgacaggcaacctgggccacaatgcccgctgggacctgctggccaaggaa
gctgcagcctgcacatctgccctgtgctgcatgggacggaatggcatccccatccagcca
tggccagtgaaggctgctgtgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (9)   
   KEGG NETWORK (9)   
Disease (1)   
   OMIM (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (87)   

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