| Entry |
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| Gene name |
OGDH, AKGDH, E1k, OGDC
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| Definition |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (EC:1.2.4.2)
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| Orthology |
| 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] |
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| Organism |
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| Pathway |
| Citrate cycle (TCA cycle) | | Lysine degradation | | Tryptophan metabolism | | Metabolic pathways |
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| Module |
| Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate | | Lysine degradation, lysine => saccharopine => acetoacetyl-CoA |
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| Disease |
| Diseases of the tricarboxylic acid cycle |
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| Class |
Metabolism; Carbohydrate metabolism; Citrate cycle (TCA cycle) [PATH: hsa00020]
Metabolism; Amino acid metabolism; Lysine degradation [PATH: hsa00310]
Metabolism; Amino acid metabolism; Tryptophan metabolism [PATH: hsa00380]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Position |
7p14-p13
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| AA seq |
427 aa  
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV
DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES
DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN
GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR
VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVRPRERRARQIVKAPCSS
MEFRSPT |
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| NT seq |
1284 nt  +upstreamnt +downstreamnt
atgtttcatttaaggacttgtgctgctaagttgaggccattgacggcttcccagactgtt
aagacattttcacaaaacagaccagcagcagctaggacatttcaacagattcggtgctat
tctgcacctgttgctgctgagccctttctcagtgggactagttcgaactatgtggaggag
atgtactgtgcttggctggaaaaccccaaaagtgtacataagtcatgggacatttttttt
cgcaacacgaatgccggagccccaccgggcactgcctaccagagtccccttcccctgagc
cgaggctccctggctgctgtggcccatgcacagtccctggtagaagcacagcccaacgtg
gacaagctcgtggaggaccacctggcagtgcagtcgctcatcagggcatatcagatacga
gggcaccatgtagcacagctggaccccctggggattttggatgctgatctggactcctcc
gtgcccgctgacattatctcatccacagacaaacttgggttctatggcctggatgagtct
gacctcgacaaggtcttccacttgcccaccaccactttcatcgggggacaggaatcagca
cttcctctgcgggagatcatccgtcggctggagatggcctactgccagcatattggggtg
gagttcatgttcatcaatgacctggagcagtgccagtggatccggcagaagtttgagacc
cctgggatcatgcagttcacaaatgaggagaaacggaccctgctggccaggcttgtgcgg
tccaccaggtttgaggagttcctacagcggaagtggtcctctgagaagcgctttggtcta
gaaggctgcgaggtactgatccctgccctcaagaccatcattgacaagtctagtgagaat
ggcgtggactacgtgatcatgggcatgccacacagagggcggctgaacgtgcttgcaaat
gtcatcaggaaggagctggaacagatcttctgtcaattcgattcaaagctggaggcagct
gatgagggctccggagatgtgaagtaccacctgggcatgtatcaccgcaggatcaatcgt
gtcaccgacaggaacattaccttgtccttggtggccaacccttcccaccttgaggccgct
gaccccgtggtgatgggcaagaccaaagccgaacagttttactgtggcgacactgaaggg
aaaaaggtaaggcccagagagaggcgtgcaaggcagatcgtcaaggccccatgttccagc
atggagttccgctcaccaacataa |
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