KEGG   Homo sapiens (human): 5126
Entry
5126              CDS       T01001                                 
Symbol
PCSK2, NEC_2, NEC-2, NEC2, PC2, SPC2
Name
(RefSeq) proprotein convertase subtilisin/kexin type 2
  KO
K01360  proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5126 (PCSK2)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5126 (PCSK2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.94  proprotein convertase 2
     5126 (PCSK2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S8: subtilisin family
   5126 (PCSK2)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Subtilisin family
   5126 (PCSK2)
SSDB
Motif
Pfam: Peptidase_S8 P_proprotein S8_pro-domain Peptidase_S8_N
Other DBs
NCBI-GeneID: 5126
NCBI-ProteinID: NP_002585
OMIM: 162151
HGNC: 8744
Ensembl: ENSG00000125851
UniProt: P16519
Position
20:17226107..17484578
AA seq 638 aa
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
NT seq 1917 nt   +upstreamnt  +downstreamnt
atgaagggtggttgtgtctcccagtggaaggcggccgccgggttcctcttctgtgtcatg
gtttttgcatctgctgagcgaccggtcttcacgaatcattttcttgtggagttgcataaa
gggggagaggacaaagctcgccaagttgcagcagaacacggctttggagtccgaaagctt
ccctttgctgaaggtctgtaccacttttatcacaatggccttgcaaaggccaagagaaga
cgcagcctacaccacaagcagcagctggagagagaccccagggtaaagatggctttgcag
caggaaggatttgaccgaaaaaagcgaggttacagagacatcaatgagatcgacatcaac
atgaacgatcctctttttacaaagcagtggtatctgatcaatactgggcaagctgatggc
actcctggccttgatttgaatgtggctgaagcctgggagctgggatacacagggaaaggt
gttaccattggaattatggatgatgggattgactatctccacccggacctggcctccaac
tataatgccgaagcaagttacgacttcagcagcaacgacccctatccttaccctcggtac
acagatgactggtttaacagccacgggacccgatgtgcaggagaagtttctgctgccgcc
aacaacaatatctgtggagttggagtagcatacaactccaaggttgcaggcatccggatg
ctggaccagccattcatgacagacatcatcgaggcctcctccatcagtcatatgccacag
ctgattgacatctacagcgccagctggggccccacagacaacggcaagacagtggatggg
ccccgggagctcacgctgcaggccatggccgatggcgtgaacaagggccgcggcggcaaa
ggcagcatctacgtgtgggcctccggggacggcggcagctatgacgactgcaactgcgac
ggctacgcctccagcatgtggaccatctccatcaactcagccatcaacgacggcaggact
gccctgtacgacgagagctgctcttccaccttggcttccaccttcagcaacgggaggaaa
aggaaccccgaggccggtgtggcaaccacagatttgtacggcaactgcactctgaggcat
tctgggacatctgcagctgcccccgaggcagctggtgtgtttgcactggctctggaggct
aacctgggtctgacctggcgggacatgcagcatctgactgtgctcacctccaaacggaac
cagcttcacgacgaggtccatcagtggcggcgcaatggggtcggcctggaatttaatcac
ctctttggctacggggtccttgatgcaggtgccatggtgaaaatggctaaagactggaaa
accgtgcctgagagattccactgtgtgggaggctccgtgcaggaccctgagaaaatacca
tccactggcaagttggtgctgacactcacaaccgacgcctgtgaggggaaggaaaatttt
gtccgctacctggagcatgtccaggctgtcatcacggtcaacgcaaccagaagaggagac
ctgaacatcaacatgacttcccctatgggcaccaagtccattttgctgagccggcgtcca
agggatgacgactccaaggtgggctttgacaagtggcctttcatgaccactcacacgtgg
ggggaagacgcccgaggcacctggaccctggagctgggatttgtcggcagcgccccgcag
aagggggtgctgaaggagtggaccctgatgctgcatggcactcagagtgccccgtacatc
gaccaggtggtgcgggattaccagtccaagttggccatgtccaagaaagaggagctggag
gaagagctggacgaagccgtggagagaagcctgaaaagcatccttaacaagaactag

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Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
Protein domain (4)   
   Pfam (4)   
All databases (62)   

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