KEGG   Homo sapiens (human): 5151Help
Entry
5151              CDS       T01001                                 

Gene name
PDE8A, HsT19550
Definition
(RefSeq) phosphodiesterase 8A
  KO
K18437  
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]
Organism
hsa  Homo sapiens (human)
Pathway
Purine metabolism
Morphine addiction
Drug target
Aminophylline (DG01062): 
Bucladesine (DG00230): 
Choline theophyllinate: 
Diprophylline: 
Flavoxate (DG00477): 
Moxaverine (DG00045): 
Papaverine (DG00043): 
Propentofylline: 
Proxyphylline: 
Theophylline (DG01061): 
Tibenelast sodium: 
Trapidil: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Nucleotide metabolism
   00230 Purine metabolism
    5151 (PDE8A)
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    5151 (PDE8A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.53  3',5'-cyclic-AMP phosphodiesterase
     5151 (PDE8A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
O60658(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
15q25.3
AA seq 829 aa AA seqDB search
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG
KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF
LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF
TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA
NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI
QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL
DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS
LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS
WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH
PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG
IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM
LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS
FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
NT seq 2490 nt NT seq  +upstreamnt  +downstreamnt
atgggctgtgccccgagcatccacatttccgagcgcctggtggccgaggacgcgcctagc
cccgcggcaccgccgctgtcgtccggcgggccgcgcctcccgcagggccagaagacggcc
gccttgccccggacccgcggcgccggcctcttggagtcggagcttcgcgacggcagcggc
aagaaggtagcagtagctgatgtgcagtttggccccatgagatttcatcaagatcaactt
caggtacttttagtgtttaccaaagaagataaccaatgtaatggattctgcagggcatgt
gaaaaagcagggtttaagtgtacagttaccaaggaggctcaggctgtccttgcctgtttc
ctggacaaacatcatgacattatcatcatagaccacagaaatcctcgacagctggatgca
gaggcactgtgcaggtctatcagatcatcaaaactctcagaaaacacagttattgttggt
gtagtacgcagggtggatagagaagagttgtccgtaatgcctttcatttctgctggattt
acaaggaggtatgtagaaaaccccaacatcatggcctgctacaatgaactgctccagctg
gagtttggagaggtgcgatcacaactgaaactcagggcttgtaactcagtattcactgca
ttagaaaacagtgaagatgcaattgaaattacaagcgaagaccgttttatacagtatgca
aatcctgcatttgaaacaacaatgggctatcagtcaggtgaattaatagggaaggagtta
ggagaagtgcctataaatgaaaaaaaggctgacttgctcgatactataaattcatgcatc
aggataggcaaggagtggcaaggaatttactatgccaaaaagaaaaacggagataatata
caacaaaatgtgaagataatacctgtcattggacagggaggaaaaattagacactatgtg
tccattatcagagtgtgcaatggcaacaataaggctgagaaaatatccgaatgtgttcag
tctgacactcatacagataatcagacaggcaaacataaagacaggagaaaaggctcacta
gacgtcaaagctgttgcctcccgtgcaactgaagtttccagccagagacgacactcttcc
atggcccggatacattccatgacaattgaggcgcccatcaccaaggtaatcaatattatc
aatgctgcccaggaaagtagtcccatgcctgtgacagaagccctagaccgtgtgctggaa
attctaagaaccactgagttatattcaccacagtttggtgctaaagatgatgatccccat
gccaatgaccttgttgggggcttaatgtctgatggtttgcgaagactatcagggaatgaa
tatgttctttcaacaaaaaacactcaaatggtttcaagcaatataatcactcccatctcc
cttgatgatgtcccaccacggatagctcgggccatggaaaatgaggaatactgggacttt
gatatttttgaactggaggctgccacccacaataggcctttgatttatcttggtctcaaa
atgtttgctcgctttggaatctgtgaattcttacactgctccgagtcaacgctaagatca
tggttacaaattatcgaagccaattatcattcctccaatccctaccacaattctacacat
tctgctgatgtgcttcatgccactgcctattttctctccaaggagaggataaaggaaact
ttagatccaattgatgaggtcgctgcactcatcgcagccaccattcatgatgtggatcac
cctgggagaaccaactccttcctgtgtaatgctggaagtgagctggccattttgtacaat
gacactgctgtgctggagagccaccatgcggccttggccttccagctgaccactggagat
gataaatgcaatatatttaaaaacatggagaggaatgattatcggacactgcgccagggg
attatcgacatggtcttagccacagaaatgacaaagcactttgagcatgtcaacaaattt
gtcaacagcatcaacaaacccttggcaacactagaagaaaatggggaaactgataaaaac
caggaagtgataaacactatgcttaggactccagagaaccggaccctaatcaaacgaatg
ctgattaaatgtgctgatgtgtccaatccctgccgacccctgcagtactgcatcgagtgg
gctgcacgcatttcggaagaatatttttctcagactgatgaagagaagcagcagggctta
cctgtggtgatgccagtgtttgacagaaatacctgcagcatccccaaatcccaaatctct
ttcattgattacttcatcacagacatgtttgatgcttgggatgcctttgtagacctgcct
gatttaatgcagcatcttgacaacaactttaaatactggaaaggactggacgaaatgaag
ctgcggaacctccgaccacctcctgaatag

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