KEGG   Homo sapiens (human): 5290Help
Entry
5290              CDS       T01001                                 

Gene name
PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05100  Bacterial invasion of epithelial cells
hsa05142  Chagas disease (American trypanosomiasis)
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  HTLV-I infection
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05418  Fluid shear stress and atherosclerosis
Module
hsa_M00676  PI3K-Akt signaling
Network
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00208  KSHV K1 to host-cell-protein activation
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00221  HTLV-I Tax to host-cell-protein activation
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00272  HCV NS5A to host-cell-protein activation
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
Disease
H00027  Ovarian cancer
H00031  Breast cancer
H00048  Hepatocellular carcinoma
H01102  Pituitary adenomas
H01222  Cowden syndrome
H01431  Cushing's syndrome
H01885  Megalencephaly-capillary malformation syndrome (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01985  Desmoplastic small round cell tumor
Drug target
Alpelisib: D11011
Apitolisib: D10543
Buparlisib (DG01823): D10584 D10609
Copanlisib (DG01926): D10797 D10798 D10867
Dactolisib (DG01826): D10552 D10616
Gedatolisib: D10635
Omipalisib: D10718
Pictilisib: D10189
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5290 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5290 (PIK3CA)
   04015 Rap1 signaling pathway
    5290 (PIK3CA)
   04012 ErbB signaling pathway
    5290 (PIK3CA)
   04370 VEGF signaling pathway
    5290 (PIK3CA)
   04630 Jak-STAT signaling pathway
    5290 (PIK3CA)
   04668 TNF signaling pathway
    5290 (PIK3CA)
   04066 HIF-1 signaling pathway
    5290 (PIK3CA)
   04068 FoxO signaling pathway
    5290 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    5290 (PIK3CA)
   04072 Phospholipase D signaling pathway
    5290 (PIK3CA)
   04071 Sphingolipid signaling pathway
    5290 (PIK3CA)
   04024 cAMP signaling pathway
    5290 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    5290 (PIK3CA)
   04152 AMPK signaling pathway
    5290 (PIK3CA)
   04150 mTOR signaling pathway
    5290 (PIK3CA)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5290 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    5290 (PIK3CA)
   04218 Cellular senescence
    5290 (PIK3CA)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5290 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    5290 (PIK3CA)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5290 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5290 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    5290 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    5290 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    5290 (PIK3CA)
   04660 T cell receptor signaling pathway
    5290 (PIK3CA)
   04662 B cell receptor signaling pathway
    5290 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    5290 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    5290 (PIK3CA)
   04670 Leukocyte transendothelial migration
    5290 (PIK3CA)
   04062 Chemokine signaling pathway
    5290 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    5290 (PIK3CA)
   04923 Regulation of lipolysis in adipocyte
    5290 (PIK3CA)
   04915 Estrogen signaling pathway
    5290 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    5290 (PIK3CA)
   04917 Prolactin signaling pathway
    5290 (PIK3CA)
   04926 Relaxin signaling pathway
    5290 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    5290 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    5290 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5290 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    5290 (PIK3CA)
   04722 Neurotrophin signaling pathway
    5290 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5290 (PIK3CA)
  Development
   04360 Axon guidance
    5290 (PIK3CA)
   04380 Osteoclast differentiation
    5290 (PIK3CA)
  Aging
   04211 Longevity regulating pathway - mammal
    5290 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    5290 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5290 (PIK3CA)
   05230 Central carbon metabolism in cancer
    5290 (PIK3CA)
   05231 Choline metabolism in cancer
    5290 (PIK3CA)
   05206 MicroRNAs in cancer
    5290 (PIK3CA)
   05205 Proteoglycans in cancer
    5290 (PIK3CA)
   05203 Viral carcinogenesis
    5290 (PIK3CA)
   05210 Colorectal cancer
    5290 (PIK3CA)
   05212 Pancreatic cancer
    5290 (PIK3CA)
   05225 Hepatocellular carcinoma
    5290 (PIK3CA)
   05226 Gastric cancer
    5290 (PIK3CA)
   05214 Glioma
    5290 (PIK3CA)
   05221 Acute myeloid leukemia
    5290 (PIK3CA)
   05220 Chronic myeloid leukemia
    5290 (PIK3CA)
   05218 Melanoma
    5290 (PIK3CA)
   05211 Renal cell carcinoma
    5290 (PIK3CA)
   05215 Prostate cancer
    5290 (PIK3CA)
   05213 Endometrial cancer
    5290 (PIK3CA)
   05224 Breast cancer
    5290 (PIK3CA)
   05222 Small cell lung cancer
    5290 (PIK3CA)
   05223 Non-small cell lung cancer
    5290 (PIK3CA)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    5290 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5290 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5290 (PIK3CA)
   04931 Insulin resistance
    5290 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5290 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    5290 (PIK3CA)
   05166 HTLV-I infection
    5290 (PIK3CA)
   05162 Measles
    5290 (PIK3CA)
   05164 Influenza A
    5290 (PIK3CA)
   05161 Hepatitis B
    5290 (PIK3CA)
   05160 Hepatitis C
    5290 (PIK3CA)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    5290 (PIK3CA)
   05169 Epstein-Barr virus infection
    5290 (PIK3CA)
   05165 Human papillomavirus infection
    5290 (PIK3CA)
   05146 Amoebiasis
    5290 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    5290 (PIK3CA)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5290 (PIK3CA)
   01524 Platinum drug resistance
    5290 (PIK3CA)
   01522 Endocrine resistance
    5290 (PIK3CA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5290 (PIK3CA)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5290 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 ASC DUF4135 Ribosomal_S15
Motif
Other DBs
NCBI-GeneID: 5290
NCBI-ProteinID: NP_006209
OMIM: 171834
HGNC: 8975
Ensembl: ENSG00000121879
Vega: OTTHUMG00000157311
Pharos: P42336(Tchem)
UniProt: P42336 Q4LE51
Structure
PDB: 

Jmol
Position
3q26.32
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagtcacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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