KEGG   Homo sapiens (human): 5291Help
Entry
5291              CDS       T01001                                 

Gene name
PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5291 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5291 (PIK3CB)
   04015 Rap1 signaling pathway
    5291 (PIK3CB)
   04012 ErbB signaling pathway
    5291 (PIK3CB)
   04370 VEGF signaling pathway
    5291 (PIK3CB)
   04630 Jak-STAT signaling pathway
    5291 (PIK3CB)
   04668 TNF signaling pathway
    5291 (PIK3CB)
   04066 HIF-1 signaling pathway
    5291 (PIK3CB)
   04068 FoxO signaling pathway
    5291 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    5291 (PIK3CB)
   04024 cAMP signaling pathway
    5291 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    5291 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    5291 (PIK3CB)
   04152 AMPK signaling pathway
    5291 (PIK3CB)
   04150 mTOR signaling pathway
    5291 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    5291 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    5291 (PIK3CB)
  Cellular commiunity
   04510 Focal adhesion
    5291 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    5291 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5291 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    5291 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    5291 (PIK3CB)
   04660 T cell receptor signaling pathway
    5291 (PIK3CB)
   04662 B cell receptor signaling pathway
    5291 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    5291 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    5291 (PIK3CB)
   04670 Leukocyte transendothelial migration
    5291 (PIK3CB)
   04062 Chemokine signaling pathway
    5291 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    5291 (PIK3CB)
   04915 Estrogen signaling pathway
    5291 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    5291 (PIK3CB)
   04917 Prolactin signaling pathway
    5291 (PIK3CB)
   04921 Oxytocin signaling pathway
    5291 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    5291 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5291 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    5291 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5291 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    5291 (PIK3CB)
   04722 Neurotrophin signaling pathway
    5291 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5291 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    5291 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5291 (PIK3CB)
   05205 Proteoglycans in cancer
    5291 (PIK3CB)
   05203 Viral carcinogenesis
    5291 (PIK3CB)
   05210 Colorectal cancer
    5291 (PIK3CB)
   05212 Pancreatic cancer
    5291 (PIK3CB)
   05214 Glioma
    5291 (PIK3CB)
   05221 Acute myeloid leukemia
    5291 (PIK3CB)
   05220 Chronic myeloid leukemia
    5291 (PIK3CB)
   05218 Melanoma
    5291 (PIK3CB)
   05211 Renal cell carcinoma
    5291 (PIK3CB)
   05215 Prostate cancer
    5291 (PIK3CB)
   05213 Endometrial cancer
    5291 (PIK3CB)
   05222 Small cell lung cancer
    5291 (PIK3CB)
   05223 Non-small cell lung cancer
    5291 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5291 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5291 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    5291 (PIK3CB)
   05166 HTLV-I infection
    5291 (PIK3CB)
   05162 Measles
    5291 (PIK3CB)
   05164 Influenza A
    5291 (PIK3CB)
   05161 Hepatitis B
    5291 (PIK3CB)
   05160 Hepatitis C
    5291 (PIK3CB)
   05169 Epstein-Barr virus infection
    5291 (PIK3CB)
   05146 Amoebiasis
    5291 (PIK3CB)
   05145 Toxoplasmosis
    5291 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    5291 (PIK3CB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5291 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
Position
3q22.3
AA seq 582 aa AA seqDB search
MLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKSRGGKKFLPVLKEILDRDPLS
QLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALE
LLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNR
RIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKL
NAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWL
VYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRS
GLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGY
CVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVI
QQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSL
ALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 1749 nt NT seq  +upstreamnt  +downstreamnt
atgttgaatccaatgggaactgttcaaacaaatccatatactgaaaatgcaacagctttg
catgttaaatttccagagaataaaaaacaaccttattattaccctcccttcgataagagt
cgaggtggaaaaaagtttcttcctgtattgaaagaaatcttggacagggatcccttgtct
caactgtgtgaaaatgaaatggatcttatttggactttgcgacaagactgccgagagatt
ttcccacaatcactgccaaaattactgctgtcaatcaagtggaataaacttgaggatgtt
gctcagcttcaggcgctgcttcagatttggcctaaactgcccccccgggaggccctagag
cttctggatttcaactatccagaccagtacgttcgagaatatgctgtaggctgcctgcga
cagatgagtgatgaagaactttctcaatatcttttacaactggtgcaagtgttaaaatat
gagccttttcttgattgtgccctctctagattcctattagaaagagcacttggtaatcgg
aggatagggcagtttctattttggcatcttaggtcagaagtgcacattcctgctgtctca
gtacaatttggtgtcatccttgaagcatactgccggggaagtgtggggcacatgaaagtg
ctttctaagcaggttgaagcactcaataagttaaaaactttaaatagtttaatcaaactg
aatgccgtgaagttaaacagagccaaagggaaggaggccatgcatacctgtttaaaacag
agtgcttaccgggaagccctctctgacctgcagtcacccctgaacccatgtgttatcctc
tcagaactctatgttgaaaagtgcaaatacatggattccaaaatgaagcctttgtggctg
gtatacaataacaaggtatttggtgaggattcagttggagtgatttttaaaaatggtgat
gatttacgacaggatatgttgacactccaaatgttgcgcttgatggatttactctggaaa
gaagctggtttggatcttcggatgttgccttatggctgtttagcaacaggagatcgctct
ggcctcattgaagttgtgagcacctctgaaacaattgctgacattcagctgaacagtagc
aatgtggctgctgcagcagccttcaacaaagatgcccttctgaactggcttaaagaatac
aactctggggatgacctggaccgagccattgaggaatttacactgtcctgtgctggctac
tgtgtagcttcttatgtccttgggattggtgacagacatagtgacaacatcatggtcaaa
aaaactggccagctcttccacattgactttggacatattcttggaaatttcaaatctaag
tttggcattaaaagggagcgagtgccttttattcttacctatgatttcatccatgtcatt
caacaaggaaaaacaggaaatacagaaaagtttggccggttccgccagtgttgtgaggat
gcatatctgattttacgacggcatgggaatctcttcatcactctctttgcgctgatgttg
actgcagggcttcctgaactcacatcagtcaaagatatacagtatcttaaggactctctt
gcattagggaagagtgaagaagaagcactcaaacagtttaagcaaaaatttgatgaggcg
ctcagggaaagctggactactaaagtgaactggatggcccacacagttcggaaagactac
agatcttaa

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