KEGG   Homo sapiens (human): 5295Help
Entry
5295              CDS       T01001                                 

Gene name
PIK3R1, AGM7, GRB1, p85, p85-ALPHA
Definition
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Orthology
K02649  
phosphoinositide-3-kinase, regulatory subunit
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Disease
H01370  
SHORT syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5295 (PIK3R1)
   04015 Rap1 signaling pathway
    5295 (PIK3R1)
   04012 ErbB signaling pathway
    5295 (PIK3R1)
   04370 VEGF signaling pathway
    5295 (PIK3R1)
   04630 Jak-STAT signaling pathway
    5295 (PIK3R1)
   04668 TNF signaling pathway
    5295 (PIK3R1)
   04066 HIF-1 signaling pathway
    5295 (PIK3R1)
   04068 FoxO signaling pathway
    5295 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    5295 (PIK3R1)
   04024 cAMP signaling pathway
    5295 (PIK3R1)
   04022 cGMP - PKG signaling pathway
    5295 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    5295 (PIK3R1)
   04152 AMPK signaling pathway
    5295 (PIK3R1)
   04150 mTOR signaling pathway
    5295 (PIK3R1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    5295 (PIK3R1)
  Cell growth and death
   04210 Apoptosis
    5295 (PIK3R1)
  Cell communication
   04510 Focal adhesion
    5295 (PIK3R1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5295 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    5295 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    5295 (PIK3R1)
   04660 T cell receptor signaling pathway
    5295 (PIK3R1)
   04662 B cell receptor signaling pathway
    5295 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    5295 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    5295 (PIK3R1)
   04670 Leukocyte transendothelial migration
    5295 (PIK3R1)
   04062 Chemokine signaling pathway
    5295 (PIK3R1)
  Endocrine system
   04910 Insulin signaling pathway
    5295 (PIK3R1)
   04915 Estrogen signaling pathway
    5295 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    5295 (PIK3R1)
   04917 Prolactin signaling pathway
    5295 (PIK3R1)
   04921 Oxytocin signaling pathway
    5295 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    5295 (PIK3R1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5295 (PIK3R1)
  Digestive system
   04973 Carbohydrate digestion and absorption
    5295 (PIK3R1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5295 (PIK3R1)
  Nervous system
   04725 Cholinergic synapse
    5295 (PIK3R1)
   04722 Neurotrophin signaling pathway
    5295 (PIK3R1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5295 (PIK3R1)
  Development
   04380 Osteoclast differentiation
    5295 (PIK3R1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5295 (PIK3R1)
   05205 Proteoglycans in cancer
    5295 (PIK3R1)
   05203 Viral carcinogenesis
    5295 (PIK3R1)
   05210 Colorectal cancer
    5295 (PIK3R1)
   05212 Pancreatic cancer
    5295 (PIK3R1)
   05214 Glioma
    5295 (PIK3R1)
   05221 Acute myeloid leukemia
    5295 (PIK3R1)
   05220 Chronic myeloid leukemia
    5295 (PIK3R1)
   05218 Melanoma
    5295 (PIK3R1)
   05211 Renal cell carcinoma
    5295 (PIK3R1)
   05215 Prostate cancer
    5295 (PIK3R1)
   05213 Endometrial cancer
    5295 (PIK3R1)
   05222 Small cell lung cancer
    5295 (PIK3R1)
   05223 Non-small cell lung cancer
    5295 (PIK3R1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5295 (PIK3R1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5295 (PIK3R1)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    5295 (PIK3R1)
   05166 HTLV-I infection
    5295 (PIK3R1)
   05162 Measles
    5295 (PIK3R1)
   05164 Influenza A
    5295 (PIK3R1)
   05161 Hepatitis B
    5295 (PIK3R1)
   05160 Hepatitis C
    5295 (PIK3R1)
   05169 Epstein-Barr virus infection
    5295 (PIK3R1)
   05146 Amoebiasis
    5295 (PIK3R1)
   05145 Toxoplasmosis
    5295 (PIK3R1)
   05142 Chagas disease (American trypanosomiasis)
    5295 (PIK3R1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
5q13.1
AA seq 361 aa AA seqDB search
MHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVK
LLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTA
IEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRR
RLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENT
EDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVV
DGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR
R
NT seq 1086 nt NT seq  +upstreamnt  +downstreamnt
atgcatggtgattatactcttacactaaggaaagggggaaataacaaattaatcaaaata
tttcatcgagatgggaaatatggcttctctgacccattaaccttcagttctgtggttgaa
ttaataaaccactaccggaatgaatctctagctcagtataatcccaaattggatgtgaaa
ttactttatccagtatccaaataccaacaggatcaagttgtcaaagaagataatattgaa
gctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagtcgagaatat
gatagattatatgaagaatatacccgcacatcccaggaaatccaaatgaaaaggacagct
attgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacccaagagcgg
tacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaaatacaaagg
attatgcataattatgataagttgaagtctcgaatcagtgaaattattgacagtagaaga
agattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgacaaacgtatg
aacagcattaaaccagaccttatccagctgagaaagacgagagaccaatacttgatgtgg
ttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaatgaaaacact
gaagaccaatattcactggtggaagatgatgaagatttgccccatcatgatgagaagaca
tggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgagggaagcgagat
ggcacttttcttgtccgggagagcagtaaacagggctgctatgcctgctctgtagtggtg
gacggcgaagtaaagcattgtgtcataaacaaaacagcaactggctatggctttgccgag
ccctataacttgtacagctctctgaaagaactggtgctacattaccaacacacctccctt
gtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgcacagcagagg
cgatga

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