KEGG   Homo sapiens (human): 5296Help
Entry
5296              CDS       T01001                                 

Gene name
PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA
Definition
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Orthology
K02649  
phosphoinositide-3-kinase, regulatory subunit
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5296 (PIK3R2)
   04015 Rap1 signaling pathway
    5296 (PIK3R2)
   04012 ErbB signaling pathway
    5296 (PIK3R2)
   04370 VEGF signaling pathway
    5296 (PIK3R2)
   04630 Jak-STAT signaling pathway
    5296 (PIK3R2)
   04668 TNF signaling pathway
    5296 (PIK3R2)
   04066 HIF-1 signaling pathway
    5296 (PIK3R2)
   04068 FoxO signaling pathway
    5296 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    5296 (PIK3R2)
   04024 cAMP signaling pathway
    5296 (PIK3R2)
   04022 cGMP - PKG signaling pathway
    5296 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    5296 (PIK3R2)
   04152 AMPK signaling pathway
    5296 (PIK3R2)
   04150 mTOR signaling pathway
    5296 (PIK3R2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    5296 (PIK3R2)
  Cell growth and death
   04210 Apoptosis
    5296 (PIK3R2)
  Cellular commiunity
   04510 Focal adhesion
    5296 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    5296 (PIK3R2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5296 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    5296 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    5296 (PIK3R2)
   04660 T cell receptor signaling pathway
    5296 (PIK3R2)
   04662 B cell receptor signaling pathway
    5296 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    5296 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    5296 (PIK3R2)
   04670 Leukocyte transendothelial migration
    5296 (PIK3R2)
   04062 Chemokine signaling pathway
    5296 (PIK3R2)
  Endocrine system
   04910 Insulin signaling pathway
    5296 (PIK3R2)
   04915 Estrogen signaling pathway
    5296 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    5296 (PIK3R2)
   04917 Prolactin signaling pathway
    5296 (PIK3R2)
   04921 Oxytocin signaling pathway
    5296 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    5296 (PIK3R2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5296 (PIK3R2)
  Digestive system
   04973 Carbohydrate digestion and absorption
    5296 (PIK3R2)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5296 (PIK3R2)
  Nervous system
   04725 Cholinergic synapse
    5296 (PIK3R2)
   04722 Neurotrophin signaling pathway
    5296 (PIK3R2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5296 (PIK3R2)
  Development
   04380 Osteoclast differentiation
    5296 (PIK3R2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5296 (PIK3R2)
   05230 Central carbon metabolism in cancer
    5296 (PIK3R2)
   05231 Choline metabolism in cancer
    5296 (PIK3R2)
   05206 MicroRNAs in cancer
    5296 (PIK3R2)
   05205 Proteoglycans in cancer
    5296 (PIK3R2)
   05203 Viral carcinogenesis
    5296 (PIK3R2)
   05210 Colorectal cancer
    5296 (PIK3R2)
   05212 Pancreatic cancer
    5296 (PIK3R2)
   05214 Glioma
    5296 (PIK3R2)
   05221 Acute myeloid leukemia
    5296 (PIK3R2)
   05220 Chronic myeloid leukemia
    5296 (PIK3R2)
   05218 Melanoma
    5296 (PIK3R2)
   05211 Renal cell carcinoma
    5296 (PIK3R2)
   05215 Prostate cancer
    5296 (PIK3R2)
   05213 Endometrial cancer
    5296 (PIK3R2)
   05222 Small cell lung cancer
    5296 (PIK3R2)
   05223 Non-small cell lung cancer
    5296 (PIK3R2)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5296 (PIK3R2)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    5296 (PIK3R2)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    5296 (PIK3R2)
   05166 HTLV-I infection
    5296 (PIK3R2)
   05162 Measles
    5296 (PIK3R2)
   05164 Influenza A
    5296 (PIK3R2)
   05161 Hepatitis B
    5296 (PIK3R2)
   05160 Hepatitis C
    5296 (PIK3R2)
   05169 Epstein-Barr virus infection
    5296 (PIK3R2)
   05146 Amoebiasis
    5296 (PIK3R2)
   05145 Toxoplasmosis
    5296 (PIK3R2)
   05142 Chagas disease (American trypanosomiasis)
    5296 (PIK3R2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
19q13.2-q13.4
AA seq 728 aa AA seqDB search
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
PGPPPAAR
NT seq 2187 nt NT seq  +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggcg
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggctccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccgcccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacacggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggcctcggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
ccgtcctcgccgccgccagggggcgctcccgacgggagtgagcccagccctgacttcccg
gcgctgctggtggagaagctgcttcaggaacacttggaagagcaggaggttgcgccccca
gcgctgccgcctaaaccccccaaggcaaagccggcccccacagtcctggccaatggaggg
agcccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtg
aacgagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaag
atccagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtc
ttccaccgagatgggcactatggcttctcagagccactcaccttctgctccgttgtggac
ctcatcaatcactaccgccacgagtctctggcccagtacaatgccaagctggacacacgg
ctcctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggacagcgtggag
gcagtgggcgcccagcttaaggtctatcaccagcagtaccaggacaagagccgcgagtat
gaccagctttatgaagagtacacacggacctcccaggagctgcagatgaagcgtactgca
attgaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaaa
tgcagcaaggaatacctggagcgcttccggcgtgagggcaacgagaaagagatgcaaagg
atcctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacg
aagctggagcagcagctgcgggcccaggcctcggacaacagagagatcgacaagcgcatg
aacagcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtgg
ctcacccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgag
actgaggaccagtacgcactcatggaggacgaggacgatctcccgcaccacgaggaacgc
acttggtacgtgggcaagatcaaccgcacgcaggcagaggagatgctgagtggcaagcgg
gatggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtggta
gtggacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcg
gagccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcg
ctggtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgccccgggc
cccggcccgccgcctgccgcccgctga

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