KEGG   Homo sapiens (human): 5320Help
Entry
5320              CDS       T01001                                 

Gene name
PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2
Definition
(RefSeq) phospholipase A2 group IIA
  KO
K01047  secretory phospholipase A2 [EC:3.1.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00564  Glycerophospholipid metabolism
hsa00565  Ether lipid metabolism
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00592  alpha-Linolenic acid metabolism
hsa01100  Metabolic pathways
hsa04014  Ras signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04972  Pancreatic secretion
hsa04975  Fat digestion and absorption
Drug target
Varespladib (DG01394): D06283 D08107 D08221
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Lipid metabolism
   00564 Glycerophospholipid metabolism
    5320 (PLA2G2A)
   00565 Ether lipid metabolism
    5320 (PLA2G2A)
   00590 Arachidonic acid metabolism
    5320 (PLA2G2A)
   00591 Linoleic acid metabolism
    5320 (PLA2G2A)
   00592 alpha-Linolenic acid metabolism
    5320 (PLA2G2A)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5320 (PLA2G2A)
 Organismal Systems
  Circulatory system
   04270 Vascular smooth muscle contraction
    5320 (PLA2G2A)
  Digestive system
   04972 Pancreatic secretion
    5320 (PLA2G2A)
   04975 Fat digestion and absorption
    5320 (PLA2G2A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     5320 (PLA2G2A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    5320 (PLA2G2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Phospholip_A2_1
Motif
Other DBs
NCBI-GeneID: 5320
NCBI-ProteinID: NP_000291
OMIM: 172411
HGNC: 9031
Ensembl: ENSG00000188257
Vega: OTTHUMG00000002699
Pharos: P14555(Tchem)
UniProt: P14555 A0A024RA96
Structure
PDB: 

Jmol
Position
1p36.13
AA seq 144 aa AA seqDB search
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
NT seq 435 nt NT seq  +upstreamnt  +downstreamnt
atgaagaccctcctactgttggcagtgatcatgatctttggcctactgcaggcccatggg
aatttggtgaatttccacagaatgatcaagttgacgacaggaaaggaagccgcactcagt
tatggcttctacggctgccactgtggcgtgggtggcagaggatcccccaaggatgcaacg
gatcgctgctgtgtcactcatgactgttgctacaaacgtctggagaaacgtggatgtggc
accaaatttctgagctacaagtttagcaactcggggagcagaatcacctgtgcaaaacag
gactcctgcagaagtcaactgtgtgagtgtgataaggctgctgccacctgttttgctaga
aacaagacgacctacaataaaaagtaccagtactattccaataaacactgcagagggagc
acccctcgttgctga

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