KEGG   Homo sapiens (human): 53358
Entry
53358             CDS       T01001                                 
Symbol
SHC3, N-Shc, NSHC, RAI, SHCC
Name
(RefSeq) SHC adaptor protein 3
  KO
K17448  SHC-transforming protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04510  Focal adhesion
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa04910  Insulin signaling pathway
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
hsa05034  Alcoholism
hsa05100  Bacterial invasion of epithelial cells
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06526  MAPK signaling
  Element
N01595  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    53358 (SHC3)
   04014 Ras signaling pathway
    53358 (SHC3)
   04072 Phospholipase D signaling pathway
    53358 (SHC3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    53358 (SHC3)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    53358 (SHC3)
   04062 Chemokine signaling pathway
    53358 (SHC3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    53358 (SHC3)
   04915 Estrogen signaling pathway
    53358 (SHC3)
   04917 Prolactin signaling pathway
    53358 (SHC3)
   04926 Relaxin signaling pathway
    53358 (SHC3)
   04935 Growth hormone synthesis, secretion and action
    53358 (SHC3)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    53358 (SHC3)
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    53358 (SHC3)
   05226 Gastric cancer
    53358 (SHC3)
   05214 Glioma
    53358 (SHC3)
   05220 Chronic myeloid leukemia
    53358 (SHC3)
   05224 Breast cancer
    53358 (SHC3)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    53358 (SHC3)
  09165 Substance dependence
   05034 Alcoholism
    53358 (SHC3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    53358 (SHC3)
   01522 Endocrine resistance
    53358 (SHC3)
SSDB
Motif
Pfam: PID SH2
Other DBs
NCBI-GeneID: 53358
NCBI-ProteinID: NP_058544
OMIM: 605263
HGNC: 18181
Ensembl: ENSG00000148082
UniProt: Q92529
Position
9:complement(89005771..89178818)
AA seq 594 aa
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
NT seq 1785 nt   +upstreamnt  +downstreamnt
atgcttccacgcaccaagtataaccgcttcaggaatgactcggtgacatcggtcgatgac
cttctccacagcctgtcggtgagcggcggcggaggcaaggtttcggcggcgcgcgcgacc
ccggcggcggctccctacttggtgtccggcgaggcgctgcgcaaggcgcccgacgatggg
cccggcagcctgggccacctgctccacaaggtgtcccacctgaaactctccagctcgggc
ctccgcggcctgtcgtcggccgcccgggagcgggcgggcgcgcggctctcgggcagctgc
agcgcgcccagcctggccgccccggacggcagtgcgccctcggcgccccgcgccccggcc
atgagcgccgccaggaagggccggcccggcgacgagccgctgcccaggccccctcggggg
gcgccgcacgccagcgaccaggtgctggggcccggagtcacctacgtggtcaagtacttg
gggtgcattgaagttctgcgctcaatgaggtctcttgacttcagtacaagaacacaaatt
accagggaagccatcagccgcgtctgtgaagctgtgcctggtgcgaagggagccttcaag
aagagaaagcctccaagcaaaatgctgtccagcatcttgggaaagagcaacctccagttt
gcgggaatgagcatctctctgaccatctccacggccagtctgaacctgcgaactccggac
tccaaacagatcatagcgaatcaccacatgcggtccatctccttcgcctctgggggagac
ccggacacaactgactatgttgcatatgtggctaaggaccctgttaatcgcagagcttgt
cacattttggaatgctgtgatgggctggcccaggatgtcatcggctccatcggacaagcc
tttgagctccggtttaagcaatatttacagtgtcctaccaagattcccgctctccatgat
cgaatgcagagtctggatgagccatggacggaagaggagggagatggctcagaccaccca
tactacaacagcatcccaagcaagatgcctcctccagggggctttcttgatactagactg
aaacccagaccccatgctcctgacacagcccagtttgcaggaaaagagcagacttattac
cagggaagacacttaggagacacttttggcgaagactggcagcaaacacctttaaggcaa
gggtcctcggacatctacagcacgccagaagggaaactgcacgtggcccccacgggagaa
gcacccacctacgtcaacactcagcagatcccaccacaggcctggccggctgcggtcagc
agtgctgagagcagcccaaggaaagacctctttgacatgaaaccttttgaagatgctctc
aagaaccagcccttggggcccgtgttaagcaaggcagcctccgtggagtgcatcagccct
gtgtcacctagagccccagatgccaagatgctggaggaactgcaagccgagacttggtac
caaggagagatgagcaggaaggaggcagaggggctgctggagaaagacggagacttcctg
gtcaggaagagcaccaccaacccgggctcctttgtcctcacgggcatgcacaatggccag
gccaagcacctgctgctcgtggacccagaaggcacgatccggacaaaggacagagtcttt
gacagtatcagccacctcatcaaccaccacctagaaagcagcctgcccattgtctctgca
gggagtgagctgtgtctccagcagccagtggagaggaagcagtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (21)   
   KEGG PATHWAY (21)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (2)   
   Pfam (2)   
All databases (63)   

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