KEGG   Homo sapiens (human): 5336Help
Entry
5336              CDS       T01001                                 

Gene name
PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
Definition
phospholipase C, gamma 2 (phosphatidylinositol-specific) (EC:3.1.4.11)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
hsa  Homo sapiens (human)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5336 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5336 (PLCG2)
   04012 ErbB signaling pathway
    5336 (PLCG2)
   04370 VEGF signaling pathway
    5336 (PLCG2)
   04064 NF-kappa B signaling pathway
    5336 (PLCG2)
   04066 HIF-1 signaling pathway
    5336 (PLCG2)
   04020 Calcium signaling pathway
    5336 (PLCG2)
   04070 Phosphatidylinositol signaling system
    5336 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5336 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    5336 (PLCG2)
   04662 B cell receptor signaling pathway
    5336 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    5336 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    5336 (PLCG2)
   04670 Leukocyte transendothelial migration
    5336 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    5336 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    5336 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5336 (PLCG2)
  Development
   04380 Osteoclast differentiation
    5336 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5336 (PLCG2)
   05206 MicroRNAs in cancer
    5336 (PLCG2)
   05205 Proteoglycans in cancer
    5336 (PLCG2)
   05214 Glioma
    5336 (PLCG2)
   05223 Non-small cell lung cancer
    5336 (PLCG2)
  Infectious diseases
   05110 Vibrio cholerae infection
    5336 (PLCG2)
   05120 Epithelial cell signaling in Helicobacter pylori infection
    5336 (PLCG2)
   05169 Epstein-Barr virus infection
    5336 (PLCG2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     5336 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
16q24.1
AA seq 1265 aa AA seqDB search
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccccgagcgg
agaaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctatat
ggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagtt
aactggctctctggcttgaaaatcttacaccaggaagcgatgaatgcgtccacgcccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcg
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatc
aagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggcc
ttcaaggaagtatttggcgacctgctgttgacgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggggag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccattgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggat
ataccccctacagaactacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctg
atgaggattccccgggacggggccttcctgatccggaagcgagaggggagcgactcctat
gccatcaccttcagggctaggggcaaggtaaagcattgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagcag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagtac
atgcagatgaatcacgcattgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaagtggagatctgtggagccgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagat
atgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcagtcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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