KEGG   Homo sapiens (human): 5371
Entry
5371              CDS       T01001                                 
Symbol
PML, MYL, PP8675, RNF71, TRIM19
Name
(RefSeq) PML nuclear body scaffold
  KO
K10054  E3 SUMO-protein ligase PML [EC:2.3.2.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04144  Endocytosis
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Network
nt06240  Transcription (cancer)
nt06275  Acute myeloid leukemia
  Element
N00109  PML-RARA fusion to transcriptional activtion
N00113  PML-RARA fusion to transcriptional repression
Disease
H00003  Acute myeloid leukemia
H02542  Acute promyelocytic leukemia
Drug target
Arsenic trioxide: D02106<JP/US>
Tretinoin (DG00433): D00094<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    5371 (PML)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    5371 (PML)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5371 (PML)
   05202 Transcriptional misregulation in cancer
    5371 (PML)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    5371 (PML)
  09172 Infectious disease: viral
   05164 Influenza A
    5371 (PML)
   05168 Herpes simplex virus 1 infection
    5371 (PML)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    5371 (PML)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   5371 (PML)
SSDB
Motif
Pfam: DUF3583 zf-B_box zf-C3HC4 zf-RING_5 Imm71 zf-RING_UBOX Cep57_CLD_2 ExoU_mid_dom
Other DBs
NCBI-GeneID: 5371
NCBI-ProteinID: NP_150241
OMIM: 102578
HGNC: 9113
Ensembl: ENSG00000140464
UniProt: P29590
Structure
Position
15:73994716..74047827
AA seq 882 aa
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ
HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS
LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA
FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS
NT seq 2649 nt   +upstreamnt  +downstreamnt
atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag
cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc
cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc
caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc
ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac
acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg
cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc
tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag
cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc
acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc
agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc
agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg
gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag
atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc
gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct
gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat
gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc
tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc
caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag
gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag
aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag
gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg
gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa
ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc
cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg
ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc
cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc
aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc
agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt
gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt
gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa
acccagaagattagccagctggctgcggtgaaccgggaaagcaagttccgcgtggtcatc
cagcctgaagccttcttcagcatctactccaaggccgtgtccctggaggtggggctgcag
cacttcctcagctttctgagctccatgcgccgccctatcttggcctgctacaagctgtgg
gggcctggcctcccaaacttcttccgggccctggaggacattaacaggctgtgggaattc
caggaggccatctcgggcttcctggctgccctgcctctcatccgggagcgtgtgcccggg
gccagcagcttcaaactcaagaacctggcccagacctacctggcgagaaacatgagcgag
cgcagcgccatggctgccgtgctggccatgcgtgacctgtgccgcctcctcgaggtctcc
ccgggcccccagctggcccagcatgtctaccccttcagtagcctgcagtgctttgcctcc
ctgcagcccctggtgcaggcagctgtgctgccccgggctgaggcccgcctcctggcccta
cacaacgtgagcttcatggagctgctgagtgcacaccgccgtgaccggcaggggggcctg
aagaagtacagccgctatctaagcctgcagaccaccacgttgccccctgcccagcctgct
ttcaacctgcaggctctgggcacctactttgaaggcctgttggagggtccggcgctggca
cgggcagaaggagtctccaccccacttgctggccgtggcttggcagagagggcctcccag
cagagctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (4)   
   KEGG NETWORK (4)   
Disease (3)   
   KEGG DISEASE (2)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (81)   
   RefSeq(nuc) (9)   
   GenBank (36)   
   EMBL (36)   
3D Structure (19)   
   PDB (19)   
Protein domain (8)   
   Pfam (8)   
All databases (169)   

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