KEGG   Homo sapiens (human): 545
Entry
545               CDS       T01001                                 
Symbol
ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1
Name
(RefSeq) ATR serine/threonine kinase
  KO
K06640  serine/threonine-protein kinase ATR [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle (cancer)
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N00347  p300-p21-Cell cycle G1/S
N00455  CDC25-Cell cycle G2/M
N00456  HIV Vpr to CDC25-cell cycle G2M
N00459  WEE1-Cell cycle G2/M
N00499  ATR-p21-Cell cycle G2/M
N01451  ATR signaling
N01464  Fanconi anemia pathway
Disease
H00992  Seckel syndrome
H02576  Familial cutaneous telangiectasia and cancer syndrome
Drug target
Berzosertib: D11148
Camonsertib: D12321
Ceralasertib: D11787
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    545 (ATR)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    545 (ATR)
   04115 p53 signaling pathway
    545 (ATR)
   04218 Cellular senescence
    545 (ATR)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    545 (ATR)
   05170 Human immunodeficiency virus 1 infection
    545 (ATR)
   05165 Human papillomavirus infection
    545 (ATR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    545 (ATR)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    545 (ATR)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     545 (ATR)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   545 (ATR)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    545 (ATR)
SSDB
Motif
Pfam: PI3_PI4_kinase FAT UME FATC HEAT Mad3_BUB1_I TPR_1 TRIF-NTD THP2
Other DBs
NCBI-GeneID: 545
NCBI-ProteinID: NP_001175
OMIM: 601215
HGNC: 882
Ensembl: ENSG00000175054
UniProt: Q13535
Structure
Position
3:complement(142449235..142578733)
AA seq 2644 aa
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
NT seq 7935 nt   +upstreamnt  +downstreamnt
atgggggaacatggcctggagctggcttccatgatccccgccctgcgggagctgggcagt
gccacaccagaggaatataatacagttgtacagaagccaagacaaattctgtgtcaattc
attgaccggatacttacagatgtaaatgttgttgctgtagaacttgtaaagaaaactgac
tctcagccaacctccgtgatgttgcttgatttcatccagcatatcatgaaatcctcccca
cttatgtttgtaaatgtgagtggaagccatgaggccaaaggcagttgtattgaattcagt
aattggatcataacgagacttctgcggattgcagcaactccctcctgtcatttgttacac
aagaaaatctgtgaagtcatctgttcattattatttctttttaaaagcaagagtcctgct
atttttggggtactcacaaaagaattattacaactttttgaagacttggtttacctccat
agaagaaatgtgatgggtcatgctgtggaatggccagtggtcatgagccgatttttaagt
caattagatgaacacatgggatatttacaatcagctcctttgcagttgatgagtatgcaa
aatttagaatttattgaagtcactttattaatggttcttactcgtattattgcaattgtg
ttttttagaaggcaagaactcttactttggcagataggttgtgttctgctagagtatggt
agtccaaaaattaaatccctagcaattagctttttaacagaactttttcagcttggagga
ctaccagcacaaccagctagcacttttttcagctcatttttggaattattaaaacacctt
gtagaaatggatactgaccaattgaaactctatgaagagccattatcaaagctgataaag
acactatttccctttgaagcagaagcttatagaaatattgaacctgtctatttaaatatg
ctgctggaaaaactctgtgtcatgtttgaagacggtgtgctcatgcggcttaagtctgat
ttgctaaaagcagctttgtgccatttactgcagtatttccttaaatttgtgccagctggg
tatgaatctgctttacaagtcaggaaggtctatgtgagaaatatttgtaaagctcttttg
gatgtgcttggaattgaggtagatgcagagtacttgttgggcccactttatgcagctttg
aaaatggaaagtatggaaatcattgaggagattcaatgccaaactcaacaggaaaacctc
agcagtaatagtgatggaatatcacccaaaaggcgtcgtctcagctcgtctctaaaccct
tctaaaagagcaccaaaacagactgaggaaattaaacatgtggacatgaaccaaaagagc
atattatggagtgcactgaaacagaaagctgaatcccttcagatttcccttgaatacagt
ggcctaaagaatcctgttattgagatgttagaaggaattgctgttgtcttacaactgact
gctctgtgtactgttcattgttctcatcaaaacatgaactgccgtactttcaaggactgt
caacataaatccaagaagaaaccttctgtagtgataacttggatgtcattggatttttac
acaaaagtgcttaagagctgtagaagtttgttagaatctgttcagaaactggacctggag
gcaaccattgataaggtggtgaaaatttatgatgctttgatttatatgcaagtaaacagt
tcatttgaagatcatatcctggaagatttatgtggtatgctctcacttccatggatttat
tcccattctgatgatggctgtttaaagttgaccacatttgccgctaatcttctaacatta
agctgtaggatttcagatagctattcaccacaggcacaatcacgatgtgtgtttcttctg
actctgtttccaagaagaatattccttgagtggagaacagcagtttacaactgggccctg
cagagctcccatgaagtaatccgggctagttgtgttagtggattttttatcttattgcag
cagcagaattcttgtaacagagttcccaagattcttatagataaagtcaaagatgattct
gacattgtcaagaaagaatttgcttctatacttggtcaacttgtctgtactcttcacggc
atgttttatctgacaagttctttaacagaacctttctctgaacacggacatgtggacctc
ttctgtaggaacttgaaagccacttctcaacatgaatgttcatcttctcaactaaaagct
tctgtctgcaagccattccttttcctactgaaaaaaaaaatacctagtccagtaaaactt
gctttcatagataatctacatcatctttgtaagcatcttgattttagagaagatgaaaca
gatgtaaaagcagttcttggaactttattaaatttaatggaagatccagacaaagatgtt
agagtggcttttagtggaaatatcaagcacatattggaatccttggactctgaagatgga
tttataaaggagctttttgtcttaagaatgaaggaagcatatacacatgcccaaatatca
agaaataatgagctgaaggataccttgattcttacaacaggggatattggaagggccgca
aaaggagatttggtaccatttgcactcttacacttattgcattgtttgttatccaagtca
gcatctgtctctggagcagcatacacagaaattagagctctggttgcagctaaaagtgtt
aaactgcaaagttttttcagccagtataagaaacccatctgtcagtttttggtagaatcc
cttcactctagtcagatgacagcacttccgaatactccatgccagaatgctgacgtgcga
aaacaagatgtggctcaccagagagaaatggctttaaatacgttgtctgaaattgccaac
gttttcgactttcctgatcttaatcgttttcttactaggacattacaagttctactacct
gatcttgctgccaaagcaagccctgcagcttctgctctcattcgaactttaggaaaacaa
ttaaatgtcaatcgtagagagattttaataaacaacttcaaatatattttttctcatttg
gtctgttcttgttccaaagatgaattagaacgtgcccttcattatctgaagaatgaaaca
gaaattgaactggggagcctgttgagacaagatttccaaggattgcataatgaattattg
ctgcgtattggagaacactatcaacaggtttttaatggtttgtcaatacttgcctcattt
gcatccagtgatgatccatatcagggcccgagagatatcatatcacctgaactgatggct
gattatttacaacccaaattgttgggcattttggctttttttaacatgcagttactgagc
tctagtgttggcattgaagataagaaaatggccttgaacagtttgatgtctttgatgaag
ttaatgggacccaaacatgtcagttctgtgagggtgaagatgatgaccacactgagaact
ggccttcgattcaaggatgattttcctgaattgtgttgcagagcttgggactgctttgtt
cgctgcctggatcatgcttgtctgggctcccttctcagtcatgtaatagtagctttgtta
cctcttatacacatccagcctaaagaaactgcagctatcttccactacctcataattgaa
aacagggatgctgtgcaagattttcttcatgaaatatattttttacctgatcatccagaa
ttaaaaaagataaaagccgttctccaggaatacagaaaggagacctctgagagcactgat
cttcagacaactcttcagctctctatgaaggccattcaacatgaaaatgtcgatgttcgt
attcatgctcttacaagcttgaaggaaaccttgtataaaaatcaggaaaaactgataaag
tatgcaacagacagtgaaacagtagaacctattatctcacagttggtgacagtgcttttg
aaaggttgccaagatgcaaactctcaagctcggttgctctgtggggaatgtttaggggaa
ttgggggcgatagatccaggtcgattagatttctcaacaactgaaactcaaggaaaagat
tttacatttgtgactggagtagaagattcaagctttgcctatggattattgatggagcta
acaagagcttaccttgcgtatgctgataatagccgagctcaagattcagctgcctatgcc
attcaggagttgctttctatttatgactgtagagagatggagaccaacggcccaggtcac
caattgtggaggagatttcctgagcatgttcgggaaatactagaacctcatctaaatacc
agatacaagagttctcagaagtcaaccgattggtctggagtaaagaagccaatttactta
agtaaattgggtagtaactttgcagaatggtcagcatcttgggcaggttatcttattaca
aaggttcgacatgatcttgccagtaaaattttcacctgctgtagcattatgatgaagcat
gatttcaaagtgaccatctatcttcttccacatattctggtgtatgtcttactgggttgt
aatcaagaagatcagcaggaggtttatgcagaaattatggcagttctaaagcatgacgat
cagcataccataaatacccaagacattgcatctgatctgtgtcaactcagtacacagact
gtgttctccatgcttgaccatctcacacagtgggcaaggcacaaatttcaggcactgaaa
gctgagaaatgtccacacagcaaatcaaacagaaataaggtagactcaatggtatctact
gtggattatgaagactatcagagtgtaacccgttttctagacctcataccccaggatact
ctggcagtagcttcctttcgctccaaagcatacacacgagctgtaatgcactttgaatca
tttattacagaaaagaagcaaaatattcaggaacatcttggatttttacagaaattgtat
gctgctatgcatgaacctgatggagtggccggagtcagtgcaattagaaaggcagaacca
tctctaaaagaacagatccttgaacatgaaagccttggcttgctgagggatgccactgct
tgttatgacagggctattcagctagaaccagaccagatcattcattatcatggtgtagta
aagtccatgttaggtcttggtcagctgtctactgttatcactcaggtgaatggagtgcat
gctaacaggtccgagtggacagatgaattaaacacgtacagagtggaagcagcttggaaa
ttgtcacagtgggatttggtggaaaactatttggcagcagatggaaaatctacaacatgg
agtgtcagactgggacagctattattatcagccaaaaaaagagatatcacagctttttat
gactcactgaaactagtgagagcagaacaaattgtacctctttcagctgcaagctttgaa
agaggctcctaccaacgaggatatgaatatattgtgagattgcacatgttatgtgagttg
gagcatagcatcaaaccacttttccagcattctccaggtgacagttctcaagaagattct
ctaaactgggtagctcgactagaaatgacccagaattcctacagagccaaggagcctatc
ctggctctccggagggctttactaagcctcaacaaaagaccagattacaatgaaatggtt
ggagaatgctggctgcagagtgccagggtagctagaaaggctggtcaccaccagacagcc
tacaatgctctccttaatgcaggggaatcacgactcgctgaactgtacgtggaaagggca
aagtggctctggtccaagggtgatgttcaccaggcactaattgttcttcaaaaaggtgtt
gaattatgttttcctgaaaatgaaaccccacctgagggtaagaacatgttaatccatggt
cgagctatgctactagtgggccgatttatggaagaaacagctaactttgaaagcaatgca
attatgaaaaaatataaggatgtgaccgcgtgcctgccagaatgggaggatgggcatttt
taccttgccaagtactatgacaaattgatgcccatggtcacagacaacaaaatggaaaag
caaggtgatctcatccggtatatagttcttcattttggcagatctctacaatatggaaat
cagttcatatatcagtcaatgccacgaatgttaactctatggcttgattatggtacaaag
gcatatgaatgggaaaaagctggccgctccgatcgtgtacaaatgaggaatgatttgggt
aaaataaacaaggttatcacagagcatacaaactatttagctccatatcaatttttgact
gctttttcacaattgatctctcgaatttgtcattctcacgatgaagtttttgttgtcttg
atggaaataatagccaaagtatttctagcctatcctcaacaagcaatgtggatgatgaca
gctgtgtcaaagtcatcttatcccatgcgtgtgaacagatgcaaggaaatcctcaataaa
gctattcatatgaaaaaatccttagagaagtttgttggagatgcaactcgcctaacagat
aagcttctagaattgtgcaataaaccggttgatggaagtagttccacattaagcatgagc
actcattttaaaatgcttaaaaagctggtagaagaagcaacatttagtgaaatcctcatt
cctctacaatcagtcatgatacctacacttccatcaattctgggtacccatgctaaccat
gctagccatgaaccatttcctggacattgggcctatattgcagggtttgatgatatggtg
gaaattcttgcttctcttcagaaaccaaagaagatttctttaaaaggctcagatggaaag
ttctacatcatgatgtgtaagccaaaagatgacctgagaaaggattgtagactaatggaa
ttcaattccttgattaataagtgcttaagaaaagatgcagagtctcgtagaagagaactt
catattcgaacatatgcagttattccactaaatgatgaatgtgggattattgaatgggtg
aacaacactgctggtttgagacctattctgaccaaactatataaagaaaagggagtgtat
atgacaggaaaagaacttcgccagtgtatgctaccaaagtcagcagctttatctgaaaaa
ctcaaagtattccgagaatttctcctgcccaggcatcctcctatttttcatgagtggttt
ctgagaacattccctgatcctacatcatggtacagtagtagatcagcttactgccgttcc
actgcagtaatgtcaatggttggttatattctggggcttggagaccgtcatggtgaaaat
attctctttgattctttgactggtgaatgcgtacatgtagatttcaattgtcttttcaat
aagggagaaacctttgaagttccagaaattgtgccatttcgcctgactcataatatggtt
aatggaatgggtcctatgggaacagagggtctttttcgaagagcatgtgaagttacaatg
aggctgatgcgtgatcagcgagagcctttaatgagtgtcttaaagacttttctacatgat
cctcttgtggaatggagtaaaccagtgaaagggcattccaaagcgccactgaatgaaact
ggagaagttgtcaatgaaaaggccaagacccatgttcttgacattgagcagcgactacaa
ggtgtaatcaagactcgaaatagagtgacaggactgccgttatctattgaaggacatgtg
cattaccttatacaggaagctactgatgaaaacttactatgccagatgtatcttggttgg
actccatatatgtga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (13)   
   KEGG NETWORK (13)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (30)   
   RefSeq(nuc) (16)   
   GenBank (7)   
   EMBL (7)   
3D Structure (1)   
   PDB (1)   
Protein domain (9)   
   Pfam (9)   
All databases (123)   

Download RDF
DBGET integrated database retrieval system