KEGG   Homo sapiens (human): 5533Help
Entry
5533              CDS       T01001                                 

Gene name
PPP3CC, CALNA3, CNA3, PP2Bgamma
Definition
protein phosphatase 3, catalytic subunit, gamma isozyme (EC:3.1.3.16)
Orthology
K04348  
serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Apoptosis
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Oxytocin signaling pathway
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Tuberculosis
HTLV-I infection
Drug target
Tacrolimus: 
Pimecrolimus: 
Ciclosporin: 
Tacrolimus: 
Voclosporin: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    5533 (PPP3CC)
   04310 Wnt signaling pathway
    5533 (PPP3CC)
   04370 VEGF signaling pathway
    5533 (PPP3CC)
   04020 Calcium signaling pathway
    5533 (PPP3CC)
   04022 cGMP - PKG signaling pathway
    5533 (PPP3CC)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    5533 (PPP3CC)
   04210 Apoptosis
    5533 (PPP3CC)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    5533 (PPP3CC)
   04660 T cell receptor signaling pathway
    5533 (PPP3CC)
   04662 B cell receptor signaling pathway
    5533 (PPP3CC)
  Endocrine system
   04921 Oxytocin signaling pathway
    5533 (PPP3CC)
  Nervous system
   04724 Glutamatergic synapse
    5533 (PPP3CC)
   04728 Dopaminergic synapse
    5533 (PPP3CC)
   04720 Long-term potentiation
    5533 (PPP3CC)
  Development
   04360 Axon guidance
    5533 (PPP3CC)
   04380 Osteoclast differentiation
    5533 (PPP3CC)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    5533 (PPP3CC)
   05014 Amyotrophic lateral sclerosis (ALS)
    5533 (PPP3CC)
  Substance dependence
   05031 Amphetamine addiction
    5533 (PPP3CC)
  Infectious diseases
   05152 Tuberculosis
    5533 (PPP3CC)
   05166 HTLV-I infection
    5533 (PPP3CC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5533 (PPP3CC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     5533 (PPP3CC)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
8p21.3
AA seq 521 aa AA seqDB search
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKI
INDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGY
FSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDC
LPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKT
LEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLIT
IFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEM
LVNVLNICSDDELISDDEAEDHYIPSYQKGSTTVRKEIIRNKIRAIGKMARVFSILRQES
ESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLD
RINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
NT seq 1566 nt NT seq  +upstreamnt  +downstreamnt
atgtccgggaggcgcttccacctctccaccaccgaccgcgtcatcaaagctgtccccttt
cctccaacccaacggcttactttcaaggaagtatttgagaatgggaaacctaaagttgat
gttttaaaaaaccatttggtaaaggaaggacgactggaagaggaagtagccttaaagata
atcaatgatggggctgccatcctgaggcaagagaagactatgatagaagtagatgctcca
atcacagtatgtggtgatattcatggacaattctttgacctaatgaagttatttgaagtt
ggaggatcacctagtaacacacgctacctctttctgggtgactatgtggacagaggctat
ttcagtatagagtgtgtgctgtatttatggagtttaaagattaatcatcccaaaacattg
tttctgcttcggggaaatcatgaatgcaggcatcttacagactatttcaccttcaaacag
gaatgtcgaatcaaatattcggaacaggtgtatgatgcctgtatggagacatttgactgt
cttcctcttgctgccctcttaaaccagcagtttctctgtgtacatggaggaatgtcacct
gaaattacttctttagatgacattaggaaattagacaggtttacggaacctcccgccttt
ggacctgtgtgtgacctgctttggtctgatccctcagaggattatggcaatgagaagacc
ttggagcactatacccacaacactgtccgagggtgctcttatttctacagttaccctgca
gtttgtgaatttttgcagaacaataatttactatcaattatcagagcccatgaagcccaa
gatgctgggtatcgaatgtacaggaagagccaagccacaggctttccatcacttattaca
attttctctgcccccaattacctagatgtctataacaataaagctgctgtgttgaaatat
gaaaacaatgtcatgaatatcaggcagtttaactgttctccacacccctactggcttcca
aactttatggatgttttcacatggtctttgccttttgttggggaaaaagtcacagagatg
ctggtaaatgtgctcaacatatgctctgatgacgaactgatttctgatgatgaagcagaa
gatcactacattccaagctatcagaaaggaagcactacagttcgtaaggagatcatcagg
aataagatcagagccattgggaagatggcacgggtcttttcaattcttcggcaagaaagt
gagagtgtgctgactctcaagggcctgactcccacaggcacactccctctgggcgtcctc
tcaggaggcaagcagactatcgagacagccacagtagaagcggtagaggcccgggaagcc
atcagagggttctcgcttcagcacaagatccggagttttgaagaagcgcgaggtctggac
cgaattaatgagcgaatgccaccccgaaaggatagcatacacgctggtgggccaatgaaa
tctgtaacctcagcacactcacatgctgcgcacaggagcgaccaagggaagaaagcccat
tcatga

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