KEGG   Homo sapiens (human): 5533
Entry
5533              CDS       T01001                                 
Symbol
PPP3CC, CALNA3, CNA3, PP2Bgamma
Name
(RefSeq) protein phosphatase 3 catalytic subunit gamma
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06220  Calcium signaling (cancer)
nt06528  Calcium signaling
nt06537  TCR/BCR signaling
  Element
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00401  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway
N00487  BCR-PLCG-Calcineurin signaling pathway
N01644  Lysosomal Ca2+ release
N01647  Ca2+/CAM-CN signaling pathway
Drug target
Ciclosporin: D00184<JP/US>
Pimecrolimus: D05480<US>
Ruclosporin: D10983
Tacrolimus (DG00439): D00107<JP/US> D08556
Voclosporin: D09033<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5533 (PPP3CC)
   04310 Wnt signaling pathway
    5533 (PPP3CC)
   04370 VEGF signaling pathway
    5533 (PPP3CC)
   04020 Calcium signaling pathway
    5533 (PPP3CC)
   04022 cGMP-PKG signaling pathway
    5533 (PPP3CC)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    5533 (PPP3CC)
   04218 Cellular senescence
    5533 (PPP3CC)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    5533 (PPP3CC)
   04650 Natural killer cell mediated cytotoxicity
    5533 (PPP3CC)
   04660 T cell receptor signaling pathway
    5533 (PPP3CC)
   04658 Th1 and Th2 cell differentiation
    5533 (PPP3CC)
   04659 Th17 cell differentiation
    5533 (PPP3CC)
   04662 B cell receptor signaling pathway
    5533 (PPP3CC)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    5533 (PPP3CC)
   04921 Oxytocin signaling pathway
    5533 (PPP3CC)
   04924 Renin secretion
    5533 (PPP3CC)
  09156 Nervous system
   04724 Glutamatergic synapse
    5533 (PPP3CC)
   04728 Dopaminergic synapse
    5533 (PPP3CC)
   04720 Long-term potentiation
    5533 (PPP3CC)
  09158 Development and regeneration
   04360 Axon guidance
    5533 (PPP3CC)
   04380 Osteoclast differentiation
    5533 (PPP3CC)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5533 (PPP3CC)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5533 (PPP3CC)
   05170 Human immunodeficiency virus 1 infection
    5533 (PPP3CC)
   05163 Human cytomegalovirus infection
    5533 (PPP3CC)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5533 (PPP3CC)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    5533 (PPP3CC)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5533 (PPP3CC)
   05014 Amyotrophic lateral sclerosis
    5533 (PPP3CC)
   05020 Prion disease
    5533 (PPP3CC)
   05022 Pathways of neurodegeneration - multiple diseases
    5533 (PPP3CC)
  09165 Substance dependence
   05031 Amphetamine addiction
    5533 (PPP3CC)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5533 (PPP3CC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5533 (PPP3CC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5533 (PPP3CC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     5533 (PPP3CC)
SSDB
Motif
Pfam: Metallophos DUF5378
Other DBs
NCBI-GeneID: 5533
NCBI-ProteinID: NP_005596
OMIM: 114107
HGNC: 9316
Ensembl: ENSG00000120910
UniProt: P48454
Structure
Position
8:22441078..22541125
AA seq 512 aa
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKI
INDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGY
FSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDC
LPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKT
LEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLIT
IFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEM
LVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGL
TPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPR
KDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgtccgggaggcgcttccacctctccaccaccgaccgcgtcatcaaagctgtccccttt
cctccaacccaacggcttactttcaaggaagtatttgagaatgggaaacctaaagttgat
gttttaaaaaaccatttggtaaaggaaggacgactggaagaggaagtagccttaaagata
atcaatgatggggctgccatcctgaggcaagagaagactatgatagaagtagatgctcca
atcacagtatgtggtgatattcatggacaattctttgacctaatgaagttatttgaagtt
ggaggatcacctagtaacacacgctacctctttctgggtgactatgtggacagaggctat
ttcagtatagagtgtgtgctgtatttatggagtttaaagattaatcatcccaaaacattg
tttctgcttcggggaaatcatgaatgcaggcatcttacagactatttcaccttcaaacag
gaatgtcgaatcaaatattcggaacaggtgtatgatgcctgtatggagacatttgactgt
cttcctcttgctgccctcttaaaccagcagtttctctgtgtacatggaggaatgtcacct
gaaattacttctttagatgacattaggaaattagacaggtttacggaacctcccgccttt
ggacctgtgtgtgacctgctttggtctgatccctcagaggattatggcaatgagaagacc
ttggagcactatacccacaacactgtccgagggtgctcttatttctacagttaccctgca
gtttgtgaatttttgcagaacaataatttactatcaattatcagagcccatgaagcccaa
gatgctgggtatcgaatgtacaggaagagccaagccacaggctttccatcacttattaca
attttctctgcccccaattacctagatgtctataacaataaagctgctgtgttgaaatat
gaaaacaatgtcatgaatatcaggcagtttaactgttctccacacccctactggcttcca
aactttatggatgttttcacatggtctttgccttttgttggggaaaaagtcacagagatg
ctggtaaatgtgctcaacatatgctctgatgacgaactgatttctgatgatgaagcagaa
ggaagcactacagttcgtaaggagatcatcaggaataagatcagagccattgggaagatg
gcacgggtcttttcaattcttcggcaagaaagtgagagtgtgctgactctcaagggcctg
actcccacaggcacactccctctgggcgtcctctcaggaggcaagcagactatcgagaca
gccacagtagaagcggtagaggcccgggaagccatcagagggttctcgcttcagcacaag
atccggagttttgaagaagcgcgaggtctggaccgaattaatgagcgaatgccaccccga
aaggatagcatacacgctggtgggccaatgaaatctgtaacctcagcacactcacatgct
gcgcacaggagcgaccaagggaagaaagcccattcatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (33)   
   KEGG PATHWAY (33)   
Network (13)   
   KEGG NETWORK (13)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (21)   
   RefSeq(nuc) (9)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (123)   

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