KEGG   Homo sapiens (human): 5563
Entry
5563              CDS       T01001                                 
Symbol
PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA
Name
(RefSeq) protein kinase AMP-activated catalytic subunit alpha 2
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04371  Apelin signaling pathway
hsa04530  Tight junction
hsa04710  Circadian rhythm
hsa04714  Thermogenesis
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04936  Alcoholic liver disease
hsa05410  Hypertrophic cardiomyopathy
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06522  mTOR signaling
  Element
N01576  STRAD/STK11- TSC signaling pathway
Drug target
Buformin (DG00114): D00595 D02206<JP>
Metformin (DG00113): D00944<JP/US> D04966
Phenformin (DG00112): D08351 D08352
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    5563 (PRKAA2)
   04068 FoxO signaling pathway
    5563 (PRKAA2)
   04151 PI3K-Akt signaling pathway
    5563 (PRKAA2)
   04152 AMPK signaling pathway
    5563 (PRKAA2)
   04150 mTOR signaling pathway
    5563 (PRKAA2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5563 (PRKAA2)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    5563 (PRKAA2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    5563 (PRKAA2)
   04922 Glucagon signaling pathway
    5563 (PRKAA2)
   04920 Adipocytokine signaling pathway
    5563 (PRKAA2)
   04921 Oxytocin signaling pathway
    5563 (PRKAA2)
  09149 Aging
   04211 Longevity regulating pathway
    5563 (PRKAA2)
   04213 Longevity regulating pathway - multiple species
    5563 (PRKAA2)
  09159 Environmental adaptation
   04710 Circadian rhythm
    5563 (PRKAA2)
   04714 Thermogenesis
    5563 (PRKAA2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    5563 (PRKAA2)
   05410 Hypertrophic cardiomyopathy
    5563 (PRKAA2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    5563 (PRKAA2)
   04932 Non-alcoholic fatty liver disease
    5563 (PRKAA2)
   04931 Insulin resistance
    5563 (PRKAA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5563 (PRKAA2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5563 (PRKAA2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    5563 (PRKAA2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.31  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
     5563 (PRKAA2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   5563 (PRKAA2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   Others
    5563 (PRKAA2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    5563 (PRKAA2)
  Mitophagy factors
   Other mitophagy factors
    5563 (PRKAA2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AMPK_alpha_AID AdenylateSensor ABC1 Kinase-like Kdo APH Haspin_kinase
Other DBs
NCBI-GeneID: 5563
NCBI-ProteinID: NP_006243
OMIM: 600497
HGNC: 9377
Ensembl: ENSG00000162409
UniProt: P54646
Structure
Position
1:56645314..56715335
AA seq 552 aa
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
NT seq 1659 nt   +upstreamnt  +downstreamnt
atggctgagaagcagaagcacgacgggcgggtgaagatcggacactacgtgctgggcgac
acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattaacaggccat
aaagtggcagttaaaatcttaaatagacagaagattcgcagtttagatgttgttggaaaa
ataaaacgagaaattcaaaatctaaaactctttcgtcatcctcatattatcaaactatac
caggtgatcagcactccaacagatttttttatggtaatggaatatgtgtctggaggtgaa
ttatttgactacatctgtaagcatggacgggttgaagagatggaagccaggcggctcttt
cagcagattctgtctgctgtggattactgtcataggcatatggttgttcatcgagacctg
aaaccagagaatgtcctgttggatgcacacatgaatgccaagatagccgatttcggatta
tctaatatgatgtcagatggtgaatttctgagaactagttgcggatctccaaattatgca
gcacctgaagtcatctcaggcagattgtatgcaggtcctgaagttgatatctggagctgt
ggtgttatcttgtatgctcttctttgtggcaccctcccatttgatgatgagcatgtacct
acgttatttaagaagatccgagggggtgtcttttatatcccagaatatctcaatcgttct
gtcgccactctcctgatgcatatgctgcaggttgacccactgaaacgagcaactatcaaa
gacataagagagcatgaatggtttaaacaagatttgcccagttacttatttcctgaagac
ccttcctatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt
gaatgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaagaccagctt
gcagtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc
tacctcgcctctagtcctccatctggttcttttatggatgatagtgccatgcatattccc
ccaggcctgaaacctcatccagaaaggatgccacctcttatagcagacagccccaaagca
agatgtccattggatgcactgaatacgactaagcccaaatctttagctgtgaaaaaagcc
aagtggcatcttggaatccgaagtcagagcaaaccgtatgacattatggctgaagtttac
cgagctatgaagcagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta
agaagaaaaaatccagtgactggcaattacgtgaaaatgagcttacaactttacctggtt
gataacaggagctatcttttggactttaaaagcattgatgatgaagtagtggagcagaga
tctggttcctcaacacctcagcgttcctgttctgctgctggcttacacagaccaagatca
agttttgattccacaactgcagagagccattcactttctggctctctcactggctctttg
accggaagcacattgtcttcagtttcacctcgcctgggcagtcacaccatggattttttt
gaaatgtgtgccagtctgattactactttagcccgttga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (20)   
   KEGG PATHWAY (20)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (37)   
   RefSeq(nuc) (3)   
   GenBank (17)   
   EMBL (17)   
3D Structure (13)   
   PDB (13)   
Protein domain (9)   
   Pfam (9)   
All databases (109)   

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