KEGG   Homo sapiens (human): 5579Help
Entry
5579              CDS       T01001                                 

Gene name
PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2
Definition
protein kinase C, beta (EC:2.7.11.13)
Orthology
K02677  
classical protein kinase C [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Vascular smooth muscle contraction
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Leishmaniasis
African trypanosomiasis
Amoebiasis
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5579 (PRKCB)
   04015 Rap1 signaling pathway
    5579 (PRKCB)
   04010 MAPK signaling pathway
    5579 (PRKCB)
   04012 ErbB signaling pathway
    5579 (PRKCB)
   04310 Wnt signaling pathway
    5579 (PRKCB)
   04370 VEGF signaling pathway
    5579 (PRKCB)
   04064 NF-kappa B signaling pathway
    5579 (PRKCB)
   04066 HIF-1 signaling pathway
    5579 (PRKCB)
   04020 Calcium signaling pathway
    5579 (PRKCB)
   04070 Phosphatidylinositol signaling system
    5579 (PRKCB)
   04150 mTOR signaling pathway
    5579 (PRKCB)
 Cellular Processes
  Cellular commiunity
   04510 Focal adhesion
    5579 (PRKCB)
   04530 Tight junction
    5579 (PRKCB)
   04540 Gap junction
    5579 (PRKCB)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    5579 (PRKCB)
   04662 B cell receptor signaling pathway
    5579 (PRKCB)
   04664 Fc epsilon RI signaling pathway
    5579 (PRKCB)
   04666 Fc gamma R-mediated phagocytosis
    5579 (PRKCB)
   04670 Leukocyte transendothelial migration
    5579 (PRKCB)
   04062 Chemokine signaling pathway
    5579 (PRKCB)
  Endocrine system
   04911 Insulin secretion
    5579 (PRKCB)
   04912 GnRH signaling pathway
    5579 (PRKCB)
   04921 Oxytocin signaling pathway
    5579 (PRKCB)
   04918 Thyroid hormone synthesis
    5579 (PRKCB)
   04919 Thyroid hormone signaling pathway
    5579 (PRKCB)
   04916 Melanogenesis
    5579 (PRKCB)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5579 (PRKCB)
  Digestive system
   04970 Salivary secretion
    5579 (PRKCB)
   04971 Gastric acid secretion
    5579 (PRKCB)
   04972 Pancreatic secretion
    5579 (PRKCB)
   04973 Carbohydrate digestion and absorption
    5579 (PRKCB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5579 (PRKCB)
   04961 Endocrine and other factor-regulated calcium reabsorption
    5579 (PRKCB)
  Nervous system
   04724 Glutamatergic synapse
    5579 (PRKCB)
   04727 GABAergic synapse
    5579 (PRKCB)
   04725 Cholinergic synapse
    5579 (PRKCB)
   04728 Dopaminergic synapse
    5579 (PRKCB)
   04726 Serotonergic synapse
    5579 (PRKCB)
   04720 Long-term potentiation
    5579 (PRKCB)
   04730 Long-term depression
    5579 (PRKCB)
   04723 Retrograde endocannabinoid signaling
    5579 (PRKCB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5579 (PRKCB)
  Environmental adaptation
   04713 Circadian entrainment
    5579 (PRKCB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5579 (PRKCB)
   05231 Choline metabolism in cancer
    5579 (PRKCB)
   05206 MicroRNAs in cancer
    5579 (PRKCB)
   05205 Proteoglycans in cancer
    5579 (PRKCB)
   05214 Glioma
    5579 (PRKCB)
   05223 Non-small cell lung cancer
    5579 (PRKCB)
  Substance dependence
   05031 Amphetamine addiction
    5579 (PRKCB)
   05032 Morphine addiction
    5579 (PRKCB)
  Infectious diseases
   05110 Vibrio cholerae infection
    5579 (PRKCB)
   05164 Influenza A
    5579 (PRKCB)
   05161 Hepatitis B
    5579 (PRKCB)
   05146 Amoebiasis
    5579 (PRKCB)
   05140 Leishmaniasis
    5579 (PRKCB)
   05143 African trypanosomiasis
    5579 (PRKCB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5579 (PRKCB)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  PKC family [OT]
   5579 (PRKCB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
16p11.2
AA seq 673 aa AA seqDB search
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS
FVNSEFLKPEVKS
NT seq 2022 nt NT seq  +upstreamnt  +downstreamnt
atggctgacccggctgcggggccgccgccgagcgagggcgaggagagcaccgtgcgcttc
gcccgcaaaggcgccctccggcagaagaacgtgcatgaggtcaagaaccacaaattcacc
gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctggggcttc
gggaagcagggattccagtgccaagtttgctgctttgtggtgcacaagcggtgccatgaa
tttgtcacattctcctgccctggcgctgacaagggtccagcctccgatgacccccgcagc
aaacacaagtttaagatccacacgtactccagccccacgttttgtgaccactgtgggtca
ctgctgtatggactcatccaccaggggatgaaatgtgacacctgcatgatgaatgtgcac
aagcgctgcgtgatgaatgttcccagcctgtgtggcacggaccacacggagcgccgcggc
cgcatctacatccaggcccacatcgacagggacgtcctcattgtcctcgtaagagatgct
aaaaaccttgtacctatggaccccaatggcctgtcagatccctacgtaaaactgaaactg
attcccgatcccaaaagtgagagcaaacagaagaccaaaaccatcaaatgctccctcaac
cctgagtggaatgagacatttagatttcagctgaaagaatcggacaaagacagaagactg
tcagtagagatttgggattgggatttgaccagcaggaatgacttcatgggatctttgtcc
tttgggatttctgaacttcagaaagccagtgttgatggctggtttaagttactgagccag
gaggaaggcgagtacttcaatgtgcctgtgccaccagaaggaagtgaggccaatgaagaa
ctgcggcagaaatttgagagggccaagatcagtcagggaaccaaggtcccggaagaaaag
acgaccaacactgtctccaaatttgacaacaatggcaacagagaccggatgaaactgacc
gattttaacttcctaatggtgctggggaaaggcagctttggcaaggtcatgctttcagaa
cgaaaaggcacagatgagctctatgctgtgaagatcctgaagaaggacgttgtgatccaa
gatgatgacgtggagtgcactatggtggagaagcgggtgttggccctgcctgggaagccg
cccttcctgacccagctccactcctgcttccagaccatggaccgcctgtactttgtgatg
gagtacgtgaatgggggcgacctcatgtatcacatccagcaagtcggccggttcaaggag
ccccatgctgtattttacgctgcagaaattgccatcggtctgttcttcttacagagtaag
ggcatcatttaccgtgacctaaaacttgacaacgtgatgctcgattctgagggacacatc
aagattgccgattttggcatgtgtaaggaaaacatctgggatggggtgacaaccaagaca
ttctgtggcactccagactacatcgcccccgagataattgcttatcagccctatgggaag
tccgtggattggtgggcatttggagtcctgctgtatgaaatgttggctgggcaggcaccc
tttgaaggggaggatgaagatgaactcttccaatccatcatggaacacaacgtagcctat
cccaagtctatgtccaaggaagctgtggccatctgcaaagggctgatgaccaaacaccca
ggcaaacgtctgggttgtggacctgaaggcgaacgtgatatcaaagagcatgcatttttc
cggtatattgattgggagaaacttgaacgcaaagagatccagcccccttataagccaaaa
gcttgtgggcgaaatgctgaaaacttcgaccgatttttcacccgccatccaccagtccta
acacctcccgaccaggaagtcatcaggaatattgaccaatcagaattcgaaggattttcc
tttgttaactctgaatttttaaaacccgaagtcaagagctaa

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