KEGG   Homo sapiens (human): 5590Help
Entry
5590              CDS       T01001                                 

Gene name
PRKCZ, PKC-ZETA, PKC2
Definition
(RefSeq) protein kinase C zeta (EC:2.7.11.13)
  KO
K18952  
atypical protein kinase C zeta type [EC:2.7.11.13]
Organism
hsa  Homo sapiens (human)
Pathway
Rap1 signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Endocytosis
Hippo signaling pathway
Tight junction
Platelet activation
Insulin signaling pathway
Type II diabetes mellitus
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    5590 (PRKCZ)
   04390 Hippo signaling pathway
    5590 (PRKCZ)
   04071 Sphingolipid signaling pathway
    5590 (PRKCZ)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    5590 (PRKCZ)
  Cellular commiunity
   04530 Tight junction
    5590 (PRKCZ)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5590 (PRKCZ)
   04062 Chemokine signaling pathway
    5590 (PRKCZ)
  Endocrine system
   04910 Insulin signaling pathway
    5590 (PRKCZ)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5590 (PRKCZ)
   04931 Insulin resistance
    5590 (PRKCZ)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5590 (PRKCZ)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     5590 (PRKCZ)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  PKC family [OT]
   5590 (PRKCZ)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
1p36.33-p36.2
AA seq 592 aa AA seqDB search
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
NT seq 1779 nt NT seq  +upstreamnt  +downstreamnt
atgcccagcaggaccggccccaagatggaagggagcggcggccgcgtccgcctcaaggcg
cattacgggggggacatcttcatcaccagcgtggacgccgccacgaccttcgaggagctc
tgtgaggaagtgagagacatgtgtcgtctgcaccagcagcacccgctcaccctcaagtgg
gtggacagcgaaggtgacccttgcacggtgtcctcccagatggagctggaagaggctttc
cgcctggcccgtcagtgcagggatgaaggcctcatcattcatgttttcccgagcacccct
gagcagcctggcctgccatgtccgggagaagacaaatctatctaccgccggggagccaga
agatggaggaagctgtaccgtgccaacggccacctcttccaagccaagcgctttaacagg
agagcgtactgcggtcagtgcagcgagaggatatggggcctcgcgaggcaaggctacagg
tgcatcaactgcaaactgctggtccataagcgctgccacggcctcgtcccgctgacctgc
aggaagcatatggattctgtcatgccttcccaagagcctccagtagacgacaagaacgag
gacgccgaccttccttccgaggagacagatggaattgcttacatttcctcatcccggaag
catgacagcattaaagacgactcggaggaccttaagccagttatcgatgggatggatgga
atcaaaatctctcaggggcttgggctgcaggactttgacctaatcagagtcatcgggcgc
gggagctacgccaaggttctcctggtgcggttgaagaagaatgaccaaatttacgccatg
aaagtggtgaagaaagagctggtgcatgatgacgaggatattgactgggtacagacagag
aagcacgtgtttgagcaggcatccagcaaccccttcctggtcggattacactcctgcttc
cagacgacaagtcggttgttcctggtcattgagtacgtcaacggcggggacctgatgttc
cacatgcagaggcagaggaagctccctgaggagcacgccaggttctacgcggccgagatc
tgcatcgccctcaacttcctgcacgagagggggatcatctacagggacctgaagctggac
aacgtcctcctggatgcggacgggcacatcaagctcacagactacggcatgtgcaaggaa
ggcctgggccctggtgacacaacgagcactttctgcggaaccccgaattacatcgccccc
gaaatcctgcggggagaggagtacgggttcagcgtggactggtgggcgctgggagtcctc
atgtttgagatgatggccgggcgctccccgttcgacatcatcaccgacaacccggacatg
aacacagaggactaccttttccaagtgatcctggagaagcccatccggatcccccggttc
ctgtccgtcaaagcctcccatgttttaaaaggatttttaaataaggaccccaaagagagg
ctcggctgccggccacagactggattttctgacatcaagtcccacgcgttcttccgcagc
atagactgggacttgctggagaagaagcaggcgctccctccattccagccacagatcaca
gacgactacggtctggacaactttgacacacagttcaccagcgagcccgtgcagctgacc
ccagacgatgaggatgccataaagaggatcgaccagtcagagttcgaaggctttgagtat
atcaacccattattgctgtccaccgaggagtcggtgtga

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