KEGG   Homo sapiens (human): 5595Help
Entry
5595              CDS       T01001                                 

Gene name
MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK
Definition
mitogen-activated protein kinase 3 (EC:2.7.11.24)
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5595 (MAPK3)
   04015 Rap1 signaling pathway
    5595 (MAPK3)
   04010 MAPK signaling pathway
    5595 (MAPK3)
   04012 ErbB signaling pathway
    5595 (MAPK3)
   04350 TGF-beta signaling pathway
    5595 (MAPK3)
   04370 VEGF signaling pathway
    5595 (MAPK3)
   04668 TNF signaling pathway
    5595 (MAPK3)
   04066 HIF-1 signaling pathway
    5595 (MAPK3)
   04068 FoxO signaling pathway
    5595 (MAPK3)
   04024 cAMP signaling pathway
    5595 (MAPK3)
   04022 cGMP - PKG signaling pathway
    5595 (MAPK3)
   04151 PI3K-Akt signaling pathway
    5595 (MAPK3)
   04150 mTOR signaling pathway
    5595 (MAPK3)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    5595 (MAPK3)
  Cell growth and death
   04114 Oocyte meiosis
    5595 (MAPK3)
  Cellular commiunity
   04510 Focal adhesion
    5595 (MAPK3)
   04520 Adherens junction
    5595 (MAPK3)
   04540 Gap junction
    5595 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    5595 (MAPK3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5595 (MAPK3)
   04620 Toll-like receptor signaling pathway
    5595 (MAPK3)
   04621 NOD-like receptor signaling pathway
    5595 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    5595 (MAPK3)
   04660 T cell receptor signaling pathway
    5595 (MAPK3)
   04662 B cell receptor signaling pathway
    5595 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    5595 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    5595 (MAPK3)
   04062 Chemokine signaling pathway
    5595 (MAPK3)
  Endocrine system
   04910 Insulin signaling pathway
    5595 (MAPK3)
   04912 GnRH signaling pathway
    5595 (MAPK3)
   04915 Estrogen signaling pathway
    5595 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    5595 (MAPK3)
   04917 Prolactin signaling pathway
    5595 (MAPK3)
   04921 Oxytocin signaling pathway
    5595 (MAPK3)
   04919 Thyroid hormone signaling pathway
    5595 (MAPK3)
   04916 Melanogenesis
    5595 (MAPK3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5595 (MAPK3)
   04270 Vascular smooth muscle contraction
    5595 (MAPK3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5595 (MAPK3)
  Nervous system
   04724 Glutamatergic synapse
    5595 (MAPK3)
   04725 Cholinergic synapse
    5595 (MAPK3)
   04726 Serotonergic synapse
    5595 (MAPK3)
   04720 Long-term potentiation
    5595 (MAPK3)
   04730 Long-term depression
    5595 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    5595 (MAPK3)
   04722 Neurotrophin signaling pathway
    5595 (MAPK3)
  Development
   04320 Dorso-ventral axis formation
    5595 (MAPK3)
   04360 Axon guidance
    5595 (MAPK3)
   04380 Osteoclast differentiation
    5595 (MAPK3)
  Environmental adaptation
   04713 Circadian entrainment
    5595 (MAPK3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5595 (MAPK3)
   05205 Proteoglycans in cancer
    5595 (MAPK3)
   05203 Viral carcinogenesis
    5595 (MAPK3)
   05210 Colorectal cancer
    5595 (MAPK3)
   05212 Pancreatic cancer
    5595 (MAPK3)
   05214 Glioma
    5595 (MAPK3)
   05216 Thyroid cancer
    5595 (MAPK3)
   05221 Acute myeloid leukemia
    5595 (MAPK3)
   05220 Chronic myeloid leukemia
    5595 (MAPK3)
   05218 Melanoma
    5595 (MAPK3)
   05211 Renal cell carcinoma
    5595 (MAPK3)
   05219 Bladder cancer
    5595 (MAPK3)
   05215 Prostate cancer
    5595 (MAPK3)
   05213 Endometrial cancer
    5595 (MAPK3)
   05223 Non-small cell lung cancer
    5595 (MAPK3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    5595 (MAPK3)
   05020 Prion diseases
    5595 (MAPK3)
  Substance dependence
   05034 Alcoholism
    5595 (MAPK3)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    5595 (MAPK3)
  Infectious diseases
   05132 Salmonella infection
    5595 (MAPK3)
   05131 Shigellosis
    5595 (MAPK3)
   05133 Pertussis
    5595 (MAPK3)
   05152 Tuberculosis
    5595 (MAPK3)
   05164 Influenza A
    5595 (MAPK3)
   05161 Hepatitis B
    5595 (MAPK3)
   05160 Hepatitis C
    5595 (MAPK3)
   05145 Toxoplasmosis
    5595 (MAPK3)
   05140 Leishmaniasis
    5595 (MAPK3)
   05142 Chagas disease (American trypanosomiasis)
    5595 (MAPK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     5595 (MAPK3)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   5595 (MAPK3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5595 (MAPK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
16p11.2
AA seq 357 aa AA seqDB search
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEVGQSPAAVGLGAGEQGGT
NT seq 1074 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggctcaggggggcgggggcggggagccccgtagaaccgagggggtc
ggcccgggggtcccgggggaggtggagatggtgaaggggcagccgttcgacgtgggcccg
cgctacacgcagttgcagtacatcggcgagggcgcgtacggcatggtcagctcggcctat
gaccacgtgcgcaagactcgcgtggccatcaagaagatcagccccttcgaacatcagacc
tactgccagcgcacgctccgggagatccagatcctgctgcgcttccgccatgagaatgtc
atcggcatccgagacattctgcgggcgtccaccctggaagccatgagagatgtctacatt
gtgcaggacctgatggagactgacctgtacaagttgctgaaaagccagcagctgagcaat
gaccatatctgctacttcctctaccagatcctgcggggcctcaagtacatccactccgcc
aacgtgctccaccgagatctaaagccctccaacctgctcatcaacaccacctgcgacctt
aagatttgtgatttcggcctggcccggattgccgatcctgagcatgaccacaccggcttc
ctgacggagtatgtggctacgcgctggtaccgggccccagagatcatgctgaactccaag
ggctataccaagtccatcgacatctggtctgtgggctgcattctggctgagatgctctct
aaccggcccatcttccctggcaagcactacctggatcagctcaaccacattctgggcatc
ctgggctccccatcccaggaggacctgaattgtatcatcaacatgaaggcccgaaactac
ctacagtctctgccctccaagaccaaggtggcttgggccaagcttttccccaagtcagac
tccaaagcccttgacctgctggaccggatgttaacctttaaccccaataaacggatcaca
gtggaggaagcgctggctcacccctacctggagcagtactatgacccgacggatgaggtg
ggccagtccccagcagcagtggggctgggggcaggggagcaggggggcacgtag

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