KEGG   Homo sapiens (human): 5599
Entry
5599              CDS       T01001                                 
Symbol
MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Name
(RefSeq) mitogen-activated protein kinase 8
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04024  cAMP signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04217  Necroptosis
hsa04310  Wnt signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04530  Tight junction
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04723  Retrograde endocannabinoid signaling
hsa04728  Dopaminergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04917  Prolactin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04926  Relaxin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05231  Choline metabolism in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
nt06526  MAPK signaling
nt06534  Unfolded protein response
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00503  HTLV-1 Tax to TNF-JNK signaling pathway
N00542  EGF-EGFR-RAS-JNK signaling pathway
N00543  HBV HBx to JNK signaling pathway
N00551  HBV HBs to TLR2/4-MAPK signaling pathway
N00930  Escherichia NleD to TNF-JNK signaling pathway
N00992  Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01013  IRE1a-JNK signaling pathway
N01014  Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
N01056  FAS-JNK signaling pathway
N01057  Mutation-inactivated DJ1 to FAS-JNK signaling patwhay
N01407  Metals to JNK signaling pathway
N01417  Paraquat to FAS-JNK signaling pathway
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
N01594  MLK-JNK signaling pathway
Drug target
Tanzisertib: D10168
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    5599 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5599 (MAPK8)
   04012 ErbB signaling pathway
    5599 (MAPK8)
   04014 Ras signaling pathway
    5599 (MAPK8)
   04310 Wnt signaling pathway
    5599 (MAPK8)
   04668 TNF signaling pathway
    5599 (MAPK8)
   04068 FoxO signaling pathway
    5599 (MAPK8)
   04071 Sphingolipid signaling pathway
    5599 (MAPK8)
   04024 cAMP signaling pathway
    5599 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5599 (MAPK8)
   04137 Mitophagy - animal
    5599 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    5599 (MAPK8)
   04215 Apoptosis - multiple species
    5599 (MAPK8)
   04217 Necroptosis
    5599 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5599 (MAPK8)
   04530 Tight junction
    5599 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    5599 (MAPK8)
   04621 NOD-like receptor signaling pathway
    5599 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    5599 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    5599 (MAPK8)
   04660 T cell receptor signaling pathway
    5599 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    5599 (MAPK8)
   04659 Th17 cell differentiation
    5599 (MAPK8)
   04657 IL-17 signaling pathway
    5599 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    5599 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5599 (MAPK8)
   04920 Adipocytokine signaling pathway
    5599 (MAPK8)
   04912 GnRH signaling pathway
    5599 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    5599 (MAPK8)
   04917 Prolactin signaling pathway
    5599 (MAPK8)
   04926 Relaxin signaling pathway
    5599 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    5599 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    5599 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    5599 (MAPK8)
   04722 Neurotrophin signaling pathway
    5599 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5599 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    5599 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5599 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    5599 (MAPK8)
   05231 Choline metabolism in cancer
    5599 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5599 (MAPK8)
   05212 Pancreatic cancer
    5599 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5599 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    5599 (MAPK8)
   05161 Hepatitis B
    5599 (MAPK8)
   05171 Coronavirus disease - COVID-19
    5599 (MAPK8)
   05162 Measles
    5599 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5599 (MAPK8)
   05169 Epstein-Barr virus infection
    5599 (MAPK8)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    5599 (MAPK8)
   05130 Pathogenic Escherichia coli infection
    5599 (MAPK8)
   05132 Salmonella infection
    5599 (MAPK8)
   05131 Shigellosis
    5599 (MAPK8)
   05135 Yersinia infection
    5599 (MAPK8)
   05133 Pertussis
    5599 (MAPK8)
   05152 Tuberculosis
    5599 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    5599 (MAPK8)
   05142 Chagas disease
    5599 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5599 (MAPK8)
   05012 Parkinson disease
    5599 (MAPK8)
   05016 Huntington disease
    5599 (MAPK8)
   05017 Spinocerebellar ataxia
    5599 (MAPK8)
   05020 Prion disease
    5599 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    5599 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5599 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    5599 (MAPK8)
   05415 Diabetic cardiomyopathy
    5599 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5599 (MAPK8)
   04936 Alcoholic liver disease
    5599 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    5599 (MAPK8)
   04931 Insulin resistance
    5599 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5599 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    5599 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5599 (MAPK8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     5599 (MAPK8)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   5599 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 5599
NCBI-ProteinID: NP_001265476
OMIM: 601158
HGNC: 6881
Ensembl: ENSG00000107643
UniProt: P45983 A1L4K2
Structure
Position
10:48306677..48439360
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgcgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccgacca
tttcagaatcagactcatgccaagcgggcctacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagctagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcattctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tctgattgcactttgaagattcttgacttcggtctggccaggactgcaggaacgagtttt
atgatgacgccttatgtagtgactcgctactacagagcacccgaggtcatccttggcatg
ggctacaaggaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttacgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtccttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccaacacccgtac
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatccctgacaag
cagttagatgaaagggaacacacaatagaagagtggaaagaattgatatataaggaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcatcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctctgatacagacagcagtctagaagcagcagct
gggcctctgggctgctgtagatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (73)   
   KEGG PATHWAY (73)   
Network (38)   
   KEGG NETWORK (38)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (32)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (29)   
DNA sequence (71)   
   RefSeq(nuc) (33)   
   GenBank (19)   
   EMBL (19)   
3D Structure (33)   
   PDB (33)   
Protein domain (9)   
   Pfam (9)   
All databases (276)   

Download RDF
DBGET integrated database retrieval system