KEGG   Homo sapiens (human): 5605Help
Entry
5605              CDS       T01001                                 

Gene name
MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Definition
(RefSeq) mitogen-activated protein kinase kinase 2
  KO
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Vascular smooth muscle contraction
VEGF signaling pathway
Apelin signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Cushing's syndrome
Prion diseases
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  
Mutation-activated BRAF to ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00023  
EGF-EGFR-PLCG-ERK signaling pathway
N00024  
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  
CXCR-GNB/G-ERK signaling pathway
N00157  
KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
N00276  
EGF-overexpression to RAS-ERK signaling pathway
N00277  
EREG-EGFR-RAS-ERK signaling pathway
N00278  
EREG-overexpression to RAS-ERK signaling pathway
N00279  
AREG-EGFR-RAS-ERK signaling pathway
N00280  
AREG-overexpression to RAS-ERK signaling pathway
N10008  
Kinase inhibitor to MEK downstream of BRAF mutation
Disease
H00523  
Noonan syndrome and related disorders
Drug target
Binimetinib: 
Cobimetinib (DG01825): 
Pimasertib (DG01410): 
Selumetinib (DG01414): 
Trametinib (DG00723): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5605 (MAP2K2)
   04015 Rap1 signaling pathway
    5605 (MAP2K2)
   04010 MAPK signaling pathway
    5605 (MAP2K2)
   04012 ErbB signaling pathway
    5605 (MAP2K2)
   04370 VEGF signaling pathway
    5605 (MAP2K2)
   04371 Apelin signaling pathway
    5605 (MAP2K2)
   04066 HIF-1 signaling pathway
    5605 (MAP2K2)
   04068 FoxO signaling pathway
    5605 (MAP2K2)
   04072 Phospholipase D signaling pathway
    5605 (MAP2K2)
   04071 Sphingolipid signaling pathway
    5605 (MAP2K2)
   04024 cAMP signaling pathway
    5605 (MAP2K2)
   04022 cGMP - PKG signaling pathway
    5605 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    5605 (MAP2K2)
   04150 mTOR signaling pathway
    5605 (MAP2K2)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5605 (MAP2K2)
  Cell growth and death
   04210 Apoptosis
    5605 (MAP2K2)
   04218 Cellular senescence
    5605 (MAP2K2)
  Cellular community - eukaryotes
   04540 Gap junction
    5605 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    5605 (MAP2K2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5605 (MAP2K2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    5605 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    5605 (MAP2K2)
   04660 T cell receptor signaling pathway
    5605 (MAP2K2)
   04662 B cell receptor signaling pathway
    5605 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    5605 (MAP2K2)
  Endocrine system
   04910 Insulin signaling pathway
    5605 (MAP2K2)
   04912 GnRH signaling pathway
    5605 (MAP2K2)
   04915 Estrogen signaling pathway
    5605 (MAP2K2)
   04917 Prolactin signaling pathway
    5605 (MAP2K2)
   04921 Oxytocin signaling pathway
    5605 (MAP2K2)
   04926 Relaxin signaling pathway
    5605 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    5605 (MAP2K2)
   04916 Melanogenesis
    5605 (MAP2K2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5605 (MAP2K2)
  Nervous system
   04720 Long-term potentiation
    5605 (MAP2K2)
   04730 Long-term depression
    5605 (MAP2K2)
   04722 Neurotrophin signaling pathway
    5605 (MAP2K2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5605 (MAP2K2)
   05230 Central carbon metabolism in cancer
    5605 (MAP2K2)
   05231 Choline metabolism in cancer
    5605 (MAP2K2)
   05206 MicroRNAs in cancer
    5605 (MAP2K2)
   05205 Proteoglycans in cancer
    5605 (MAP2K2)
   05210 Colorectal cancer
    5605 (MAP2K2)
   05225 Hepatocellular carcinoma
    5605 (MAP2K2)
   05226 Gastric cancer
    5605 (MAP2K2)
   05214 Glioma
    5605 (MAP2K2)
   05216 Thyroid cancer
    5605 (MAP2K2)
   05221 Acute myeloid leukemia
    5605 (MAP2K2)
   05220 Chronic myeloid leukemia
    5605 (MAP2K2)
   05218 Melanoma
    5605 (MAP2K2)
   05211 Renal cell carcinoma
    5605 (MAP2K2)
   05219 Bladder cancer
    5605 (MAP2K2)
   05215 Prostate cancer
    5605 (MAP2K2)
   05213 Endometrial cancer
    5605 (MAP2K2)
   05224 Breast cancer
    5605 (MAP2K2)
   05223 Non-small cell lung cancer
    5605 (MAP2K2)
  Neurodegenerative diseases
   05020 Prion diseases
    5605 (MAP2K2)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    5605 (MAP2K2)
  Infectious diseases
   05164 Influenza A
    5605 (MAP2K2)
   05161 Hepatitis B
    5605 (MAP2K2)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    5605 (MAP2K2)
   05165 Human papillomavirus infection
    5605 (MAP2K2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5605 (MAP2K2)
   01522 Endocrine resistance
    5605 (MAP2K2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5605 (MAP2K2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: STE group
  STE7 family
   5605 (MAP2K2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P36507(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
19p13.3
AA seq 400 aa AA seqDB search
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccctaccatcgccgag
ggcccatcccctaccagcgagggcgcctccgaggcaaacctggtggacctgcagaagaag
ctggaggagctggaacttgacgagcagcagaagaagcggctggaagcctttctcacccag
aaagccaaggtcggcgaactcaaagacgatgacttcgaaaggatctcagagctgggcgcg
ggcaacggcggggtggtcaccaaagtccagcacagaccctcgggcctcatcatggccagg
aagctgatccaccttgagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtcctgcacgaatgcaactcgccgtacatcgtgggcttctacggggccttctacagtgac
ggggagatcagcatttgcatggaacacatggacggcggctccctggaccaggtgctgaaa
gaggccaagaggattcccgaggagatcctggggaaagtcagcatcgcggttctccggggc
ttggcgtacctccgagagaagcaccagatcatgcaccgagatgtgaagccctccaacatc
ctcgtgaactctagaggggagatcaagctgtgtgacttcggggtgagcggccagctcatc
gactccatggccaactccttcgtgggcacgcgctcctacatggctccggagcggttgcag
ggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
gccgtcggaaggtaccccatccccccgcccgacgccaaagagctggaggccatctttggc
cggcccgtggtcgacggggaagaaggagagcctcacagcatctcgcctcggccgaggccc
cccgggcgccccgtcagcggtcacgggatggatagccggcctgccatggccatctttgaa
ctcctggactatattgtgaacgagccacctcctaagctgcccaacggtgtgttcaccccc
gacttccaggagtttgtcaataaatgcctcatcaagaacccagcggagcgggcggacctg
aagatgctcacaaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaaccctgcggctgaaccagcccggcacacccacgcgcaccgccgtg
tga

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