KEGG   Homo sapiens (human): 5694
Entry
5694              CDS       T01001                                 
Symbol
PSMB6, DELTA, LMPY
Name
(RefSeq) proteasome 20S subunit beta 6
  KO
K02738  20S proteasome subunit beta 1 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5694 (PSMB6)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5694 (PSMB6)
   05012 Parkinson disease
    5694 (PSMB6)
   05014 Amyotrophic lateral sclerosis
    5694 (PSMB6)
   05016 Huntington disease
    5694 (PSMB6)
   05017 Spinocerebellar ataxia
    5694 (PSMB6)
   05020 Prion disease
    5694 (PSMB6)
   05022 Pathways of neurodegeneration - multiple diseases
    5694 (PSMB6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5694 (PSMB6)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5694 (PSMB6)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5694 (PSMB6)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5694 (PSMB6)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    5694 (PSMB6)
SSDB
Motif
Pfam: Proteasome DUF1502
Other DBs
NCBI-GeneID: 5694
NCBI-ProteinID: NP_002789
OMIM: 600307
HGNC: 9543
Ensembl: ENSG00000142507
UniProt: P28072 Q6IAT9
Structure
Position
17:4796164..4798495
AA seq 239 aa
MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
NT seq 720 nt   +upstreamnt  +downstreamnt
atggcggctaccttactagctgctcggggagccgggccagcaccggcttgggggccggag
gcgttcactccagactgggaaagccgagaagtttccactgggaccactatcatggccgtg
cagtttgacgggggcgtggttctgggggcggactccagaacaaccactgggtcctacatc
gccaatcgagtgactgacaagctgacacctattcacgaccgcattttctgctgtcgctca
ggctcagctgctgatacccaggcagtagctgatgctgtcacctaccagctcggtttccac
agcattgaactgaatgagcctccactggtccacacagcagccagcctctttaaggagatg
tgttaccgataccgggaagacctgatggcgggaatcatcatcgcaggctgggaccctcaa
gaaggagggcaggtgtactcagtgcctatggggggtatgatggtaaggcagtcctttgcc
attggaggctccgggagctcctacatctatggctatgttgatgctacctaccgggaaggc
atgaccaaggaagagtgtctgcaattcactgccaatgctctcgctttggccatggagcgg
gatggctccagtggaggagtgatccgcctggcagccattgcagagtcaggggtagagcgg
caagtacttttgggagaccagatacccaaattcgccgttgccactttaccacccgcctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (8)   
   KEGG PATHWAY (8)   
Network (14)   
   KEGG NETWORK (14)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (21)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
3D Structure (78)   
   PDB (78)   
Protein domain (2)   
   Pfam (2)   
All databases (165)   

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