KEGG T01001: 5743

Homo sapiens (human): 5743

Entry

5743 CDS T01001

Gene name

PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2

Definition

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

Orthology

K11987

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa00590	Arachidonic acid metabolism
hsa01100	Metabolic pathways
hsa04064	NF-kappa B signaling pathway
hsa04370	VEGF signaling pathway
hsa04723	Retrograde endocannabinoid signaling
hsa04726	Serotonergic synapse
hsa04913	Ovarian steroidogenesis
hsa05140	Leishmaniasis
hsa05200	Pathways in cancer
hsa05204	Chemical carcinogenesis
hsa05222	Small cell lung cancer

Disease

H00017	Esophageal cancer
H00025	Penile cancer
H00046	Cholangiocarcinoma

Drug target

Benzydamine:

D01410 D07516 D07517

Acetylsalicylic acid:

D00109 D05181 D07579 D07580 D07581 D07582

Indobufen:

D07141

Aloxiprin:

D07421

Indometacin:

D00141 D01565 D02110

Ibuprofen:

D00126 D01122 D04490 D06606 D08058 D08059 D09760

Diclofenac:

D00903 D00904 D07816 D07817 D07818 D07819

Naproxen:

Celecoxib:

Phenylbutazone:

Oxyphenbutazone:

Sulindac:

Tolmetin:

Etodolac:

Acemetacin:

Proglumetacin:

Ketorolac:

Aceclofenac:

Piroxicam:

D00127 D05511 D05512 D05513

Tenoxicam:

Lornoxicam:

Meloxicam:

Ketoprofen:

Fenoprofen:

Flurbiprofen:

Tiaprofenic acid:

Oxaprozin:

Dexibuprofen:

Alminoprofen:

Dexketoprofen:

Mefenamic acid:

Tolfenamic acid:

Flufenamic acid:

Meclofenamic acid:

Rofecoxib:

Valdecoxib:

Parecoxib:

Etoricoxib:

Lumiracoxib:

Nabumetone:

Niflumic acid:

Nimesulide:

Etofenamate:

Felbinac:

Choline salicylate:

Sodium salicylate:

Salicylamide:

Salsalate:

Diflunisal:

Floctafenine:

Pranoprofen:

Nepafenac:

Bromfenac:

Other:

D00827 D01397 D01547 D01709 D01788 D01974 D03652 D03712 D04863 D05451 D05598 D07443 D07888 D08149 D08374 D08375 D08657

Class

Metabolism; Lipid metabolism; Arachidonic acid metabolism [PATH:hsa00590]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:hsa04370]
Environmental Information Processing; Signal transduction; NF-kappa B signaling pathway [PATH:hsa04064]
Organismal Systems; Endocrine system; Ovarian Steroidogenesis [PATH:hsa04913]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:hsa04726]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:hsa04723]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Chemical carcinogenesis [PATH:hsa05204]
Human Diseases; Cancers; Small cell lung cancer [PATH:hsa05222]
Human Diseases; Infectious diseases; Leishmaniasis [PATH:hsa05140]

SSDB

Motif

Pfam:

An_peroxidase EGF

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

1q25.2-q25.3

AA seq 604 aa
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL

NT seq 1815 nt +upstreamnt +downstreamnt
atgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagccatacagcaaatcct
tgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgggatttgaccagtat
aagtgcgattgtacccggacaggattctatggagaaaactgctcaacaccggaatttttg
acaagaataaaattatttctgaaacccactccaaacacagtgcactacatacttacccac
ttcaagggattttggaacgttgtgaataacattcccttccttcgaaatgcaattatgagt
tatgtgttgacatccagatcacatttgattgacagtccaccaacttacaatgctgactat
ggctacaaaagctgggaagccttctctaacctctcctattatactagagcccttcctcct
gtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagcagcttcctgattca
aatgagattgtggaaaaattgcttctaagaagaaagttcatccctgatccccagggctca
aacatgatgtttgcattctttgcccagcacttcacgcatcagtttttcaagacagatcat
aagcgagggccagctttcaccaacgggctgggccatggggtggacttaaatcatatttac
ggtgaaactctggctagacagcgtaaactgcgccttttcaaggatggaaaaatgaaatat
cagataattgatggagagatgtatcctcccacagtcaaagatactcaggcagagatgatc
taccctcctcaagtccctgagcatctacggtttgctgtggggcaggaggtctttggtctg
gtgcctggtctgatgatgtatgccacaatctggctgcgggaacacaacagagtatgcgat
gtgcttaaacaggagcatcctgaatggggtgatgagcagttgttccagacaagcaggcta
atactgataggagagactattaagattgtgattgaagattatgtgcaacacttgagtggc
tatcacttcaaactgaaatttgacccagaactacttttcaacaaacaattccagtaccaa
aatcgtattgctgctgaatttaacaccctctatcactggcatccccttctgcctgacacc
tttcaaattcatgaccagaaatacaactatcaacagtttatctacaacaactctatattg
ctggaacatggaattacccagtttgttgaatcattcaccaggcaaattgctggcagggtt
gctggtggtaggaatgttccacccgcagtacagaaagtatcacaggcttccattgaccag
agcaggcagatgaaataccagtcttttaatgagtaccgcaaacgctttatgctgaagccc
tatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcagagttggaagcactc
tatggtgacatcgatgctgtggagctgtatcctgcccttctggtagaaaagcctcggcca
gatgccatctttggtgaaaccatggtagaagttggagcaccattctccttgaaaggactt
atgggtaatgttatatgttctcctgcctactggaagccaagcacttttggtggagaagtg
ggttttcaaatcatcaacactgcctcaattcagtctctcatctgcaataacgtgaagggc
tgtccctttacttcattcagtgttccagatccagagctcattaaaacagtcaccatcaat
gcaagttcttcccgctccggactagatgatatcaatcccacagtactactaaaagaacgt
tcgactgaactgtag

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (11)   
   KEGG PATHWAY (11)   
Disease (4)   
   KEGG DISEASE (3)   
   OMIM (1)   
Drug (115)   
   KEGG DRUG (115)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (11)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
Protein domain (2)   
   Pfam (2)   
All databases (195)   

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