KEGG   Homo sapiens (human): 57646
Entry
57646             CDS       T01001                                 
Symbol
USP28
Name
(RefSeq) ubiquitin specific peptidase 28
  KO
K21122  ubiquitin carboxyl-terminal hydrolase 28 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    57646 (USP28)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    57646 (USP28)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     57646 (USP28)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   57646 (USP28)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    57646 (USP28)
SSDB
Motif
Pfam: UCH UCH_1 DUF4769 UIM UBA_4 TPR_2 TPR_3
Other DBs
NCBI-GeneID: 57646
NCBI-ProteinID: NP_065937
OMIM: 610748
HGNC: 12625
Ensembl: ENSG00000048028
UniProt: Q96RU2
Structure
Position
11:complement(113797875..113875572)
AA seq 1077 aa
MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTD
ERVKEPSQDTVATEPSEVEGSAANKEVLAKVIDLTHDNKDDLQAAIALSLLESPKIQADG
RDLNRMHEATSAETKRSKRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSL
FQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALD
LLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEG
VREGKPFCNNETFGQYPLQVNGYRNLDECLEGAMVEGDVELLPSDHSVKYGQERWFTKLP
PVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIK
ILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSV
SDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSRSSMEMPSQPAPRTVTDEEINF
VKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGH
YWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAA
PTESDQMSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQSCKIPQMESSTNSSSQDYSTS
QEPSVASSHGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVIL
AIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKR
VVERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSV
YLLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKA
ASLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAE
NLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESIQGVSTVTVK
NT seq 3234 nt   +upstreamnt  +downstreamnt
atgactgcggagctgcagcaggacgacgcggccggcgcggcagacggccacggctcgagc
tgccaaatgctgttaaatcaactgagagaaatcacaggcattcaggacccttcctttctc
catgaagctctgaaggccagtaatggtgacattactcaggcagtcagccttctcactgat
gagagagttaaggagcccagtcaagacactgttgctacagaaccatctgaagtagagggg
agtgctgccaacaaggaagtattagcaaaagttatagaccttactcatgataacaaagat
gatcttcaggctgccattgctttgagtctactggagtctcccaaaattcaagctgatgga
agagatcttaacaggatgcatgaagcaacctctgcagaaactaaacgctcaaagagaaaa
cgctgtgaagtctggggagaaaaccccaatcccaatgactggaggagagttgatggttgg
ccagttgggctgaaaaatgttggcaatacatgttggtttagtgctgttattcagtctctc
tttcaattgcctgaatttcgaagacttgttctcagttatagtctgccacaaaatgtactt
gaaaattgtcgaagtcatacagaaaagagaaatatcatgtttatgcaagagcttcagtat
ttgtttgctctaatgatgggatcaaatagaaaatttgtagacccgtctgcagccctggat
ctattaaagggagcattccgatcatctgaggaacagcagcaagatgtgagtgaattcaca
cacaagctcctggattggctagaggacgcattccagctagctgttaatgttaacagtccc
aggaacaaatctgaaaatccaatggtgcagctgttctatggtactttcctgactgaaggg
gttcgtgaaggaaaacccttttgtaacaatgagaccttcggccagtatcctcttcaggta
aacggttatcgcaacttagacgagtgtttggaaggggccatggtggagggtgatgttgag
cttcttccctccgatcactcggtgaagtatggacaagagcgttggtttacaaagctacct
ccagtgttgacctttgaactctcaagatttgagtttaatcagtcccttgggcagccagag
aaaattcacaataagctggaatttcctcagattatttatatggacaggtacatgtacagg
agcaaggagcttattcgaaataagagagagtgtattcgaaagttgaaggaggaaataaaa
attctgcagcaaaaattggaaaggtatgtgaaatatggctcaggcccagctcggttcccg
ctcccggacatgctgaaatatgttattgaatttgctagtacaaaacctgcctcagaaagc
tgtccacctgaaagtgacacacatatgacattaccactttcttcagtgcactgctcggtt
tctgaccagacatccaaggaaagtacaagtacagaaagctcttctcaggatgttgaaagt
accttttcttctcctgaagattctttacccaagtctaaaccactgacatcttctcggtct
tccatggaaatgccttcacagccagctccacgaacagtcacagatgaggagataaatttt
gttaagacctgtcttcagagatggaggagtgagattgaacaagatatacaagatttaaag
acttgtattgcaagtactactcagactattgaacagatgtactgcgatcctctccttcgt
caggtgccttatcgcttgcatgcagttcttgttcatgaaggacaagcaaatgctggacac
tattgggcctatatctataatcaaccccgacagagctggctcaagtacaatgacatctct
gttactgaatcttcctgggaagaagttgaaagagattcctatggaggcctgagaaatgtt
agtgcttactgtctgatgtacattaatgacaaactaccctacttcaatgcagaggcagcc
ccaactgaatcagatcaaatgtcagaagtggaagccctatctgtggaactcaagcattac
attcaggaggataactggcggtttgagcaggaagtagaggagtgggaagaagagcagtct
tgcaaaatccctcaaatggagtcctccaccaactcctcatcacaggactactctacatca
caagagccttcagtagcctcttctcatggggttcgctgcttgtcgtctgagcatgctgtg
attgtaaaggagcaaactgcccaggctattgcaaacacagcccgtgcctatgagaagagc
ggtgtagaagcggcactgagtgaggtgatgctgagccctgccatgcaaggggtcatcctg
gccatagctaaagcccgtcagacctttgaccgagatgggtctgaagcagggctgattaag
gcattccatgaagaatactccaggctctatcagcttgccaaagagacccccacctctcac
agtgatcctcgacttcagcatgtccttgtctactttttccaaaatgaagcacccaaaagg
gtagtagaacgaacccttctggaacagtttgcagataaaaatcttagctatgatgaaaga
tcaatcagcattatgaaggtggctcaagcgaaactgaaggaaattggtccagatgacatg
aatatggaagagtacaagaagtggcatgaagattatagtttgttccgaaaagtgtctgtg
tatctcctaacaggcctagaactctatcaaaaaggaaagtaccaagaggcactttcctac
ctggtatatgcctaccagagcaatgctgccctgctgatgaaggggccccgccggggggtc
aaagaatccgtgattgctttataccgaagaaaatgccttctggagctgaatgccaaagca
gcttctctttttgaaacaaatgatgatcactccgtaactgagggcattaatgtgatgaat
gaactgatcatcccctgcattcaccttatcattaataatgacatttccaaggatgatctg
gatgccattgaggtcatgagaaaccattggtgctcttaccttgggcaagatattgcagaa
aatctgcagctgtgcctaggggagtttctacccagacttctagatccttctgcagaaatc
atcgtcttgaaagagcctccaactattcgacccaattctccctatgacctatgtagccga
tttgcagctgtcatggagtcaattcagggagtttcaactgtgacagtgaaataa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (52)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (50)   
DNA sequence (75)   
   RefSeq(nuc) (51)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (7)   
   Pfam (7)   
All databases (164)   

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