KEGG   Homo sapiens (human): 5788Help
Entry
5788              CDS       T01001                                 

Gene name
PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Definition
(RefSeq) protein tyrosine phosphatase, receptor type C (EC:3.1.3.48)
  KO
K06478  
receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Primary immunodeficiency
Disease
H00091  
T-B+Severe combined immunodeficiencies (SCIDs)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    5788 (PTPRC)
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    5788 (PTPRC)
   04666 Fc gamma R-mediated phagocytosis
    5788 (PTPRC)
 Human Diseases
  Immune diseases
   05340 Primary immunodeficiency
    5788 (PTPRC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     5788 (PTPRC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Receptor PTPs
    5788 (PTPRC)
Cell adhesion molecules and their ligands [BR:hsa04516]
 1. Immunoglobulin Superfamily
  Immune system
   SIGLEC family
    CD22, SIGLEC2; CD22 antigen [KO:K06467]
     5788 (PTPRC)
Cellular antigens [BR:hsa04090]
 Proteins
  5788 (PTPRC)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
1q31-q32
AA seq 1306 aa AA seqDB search
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA
STFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSA
GTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAAL
PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYL
YNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVP
PGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLE
PEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFH
NFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT
KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFR
VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYK
IYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI
PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPR
KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVV
VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEA
QYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA
SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK
QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISM
IQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQV
VKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDAN
CVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
NT seq 3921 nt NT seq  +upstreamnt  +downstreamnt
atgaccatgtatttgtggcttaaactcttggcatttggctttgcctttctggacacagaa
gtatttgtgacagggcaaagcccaacaccttcccccactggattgactacagcaaagatg
cccagtgttccactttcaagtgaccccttacctactcacaccactgcattctcacccgca
agcacctttgaaagagaaaatgacttctcagagaccacaacttctcttagtccagacaat
acttccacccaagtatccccggactctttggataatgctagtgcttttaataccacaggt
gtttcatcagtacagacgcctcaccttcccacgcacgcagactcgcagacgccctctgct
ggaactgacacgcagacattcagcggctccgccgccaatgcaaaactcaaccctacccca
ggcagcaatgctatctcagatgtcccaggagagaggagtacagccagcacctttcctaca
gacccagtttccccattgacaaccaccctcagccttgcacaccacagctctgctgcctta
cctgcacgcacctccaacaccaccatcacagcgaacacctcagatgcctaccttaatgcc
tctgaaacaaccactctgagcccttctggaagcgctgtcatttcaaccacaacaatagct
actactccatctaagccaacatgtgatgaaaaatatgcaaacatcactgtggattactta
tataacaaggaaactaaattatttacagcaaagctaaatgttaatgagaatgtggaatgt
ggaaacaatacttgcacaaacaatgaggtgcataaccttacagaatgtaaaaatgcgtct
gtttccatatctcataattcatgtactgctcctgataagacattaatattagatgtgcca
ccaggggttgaaaagtttcagttacatgattgtacacaagttgaaaaagcagatactact
atttgtttaaaatggaaaaatattgaaacctttacttgtgatacacagaatattacctac
agatttcagtgtggtaatatgatatttgataataaagaaattaaattagaaaaccttgaa
cccgaacatgagtataagtgtgactcagaaatactctataataaccacaagtttactaac
gcaagtaaaattattaaaacagattttgggagtccaggagagcctcagattattttttgt
agaagtgaagctgcacatcaaggagtaattacctggaatccccctcaaagatcatttcat
aattttaccctctgttatataaaagagacagaaaaagattgcctcaatctggataaaaac
ctgatcaaatatgatttgcaaaatttaaaaccttatacgaaatatgttttatcattacat
gcctacatcattgcaaaagtgcaacgtaatggaagtgctgcaatgtgtcatttcacaact
aaaagtgctcctccaagccaggtctggaacatgactgtctccatgacatcagataatagt
atgcatgtcaagtgtaggcctcccagggaccgtaatggcccccatgaacgttaccatttg
gaagttgaagctggaaatactctggttagaaatgagtcgcataagaattgcgatttccgt
gtaaaagatcttcaatattcaacagactacacttttaaggcctattttcacaatggagac
tatcctggagaaccctttattttacatcattcaacatcttataattctaaggcactgata
gcatttctggcatttctgattattgtgacatcaatagccctgcttgttgttctctacaaa
atctatgatctacataagaaaagatcctgcaatttagatgaacagcaggagcttgttgaa
agggatgatgaaaaacaactgatgaatgtggagccaatccatgcagatattttgttggaa
acttataagaggaagattgctgatgaaggaagactttttctggctgaatttcagagcatc
ccgcgggtgttcagcaagtttcctataaaggaagctcgaaagccctttaaccagaataaa
aaccgttatgttgacattcttccttatgattataaccgtgttgaactctctgagataaac
ggagatgcagggtcaaactacataaatgccagctatattgatggtttcaaagaacccagg
aaatacattgctgcacaaggtcccagggatgaaactgttgatgatttctggaggatgatt
tgggaacagaaagccacagttattgtcatggtcactcgatgtgaagaaggaaacaggaac
aagtgtgcagaatactggccgtcaatggaagagggcactcgggcttttggagatgttgtt
gtaaagatcaaccagcacaaaagatgtccagattacatcattcagaaattgaacattgta
aataaaaaagaaaaagcaactggaagagaggtgactcacattcagttcaccagctggcca
gaccacggggtgcctgaggatcctcacttgctcctcaaactgagaaggagagtgaatgcc
ttcagcaatttcttcagtggtcccattgtggtgcactgcagtgctggtgttgggcgcaca
ggaacctatatcggaattgatgccatgctagaaggcctggaagccgagaacaaagtggat
gtttatggttatgttgtcaagctaaggcgacagagatgcctgatggttcaagtagaggcc
cagtacatcttgatccatcaggctttggtggaatacaatcagtttggagaaacagaagtg
aatttgtctgaattacatccatatctacataacatgaagaaaagggatccacccagtgag
ccgtctccactagaggctgaattccagagacttccttcatataggagctggaggacacag
cacattggaaatcaagaagaaaataaaagtaaaaacaggaattctaatgtcatcccatat
gactataacagagtgccacttaaacatgagctggaaatgagtaaagagagtgagcatgat
tcagatgaatcctctgatgatgacagtgattcagaggaaccaagcaaatacatcaatgca
tcttttataatgagctactggaaacctgaagtgatgattgctgctcagggaccactgaag
gagaccattggtgacttttggcagatgatcttccaaagaaaagtcaaagttattgttatg
ctgacagaactgaaacatggagaccaggaaatctgtgctcagtactggggagaaggaaag
caaacatatggagatattgaagttgacctgaaagacacagacaaatcttcaacttatacc
cttcgtgtctttgaactgagacattccaagaggaaagactctcgaactgtgtaccagtac
caatatacaaactggagtgtggagcagcttcctgcagaacccaaggaattaatctctatg
attcaggtcgtcaaacaaaaacttccccagaagaattcctctgaagggaacaagcatcac
aagagtacacctctactcattcactgcagggatggatctcagcaaacgggaatattttgt
gctttgttaaatctcttagaaagtgcggaaacagaagaggtagtggatatttttcaagtg
gtaaaagctctacgcaaagctaggccaggcatggtttccacattcgagcaatatcaattc
ctatatgacgtcattgccagcacctaccctgctcagaatggacaagtaaagaaaaacaac
catcaagaagataaaattgaatttgataatgaagtggacaaagtaaagcaggatgctaat
tgtgttaatccacttggtgccccagaaaagctccctgaagcaaaggaacaggctgaaggt
tctgaacccacgagtggcactgaggggccagaacattctgtcaatggtcctgcaagtcca
gctttaaatcaaggttcatag

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