KEGG   Homo sapiens (human): 5894Help
Entry
5894              CDS       T01001                                 

Gene name
RAF1, CMD1NN, CRAF, NS5, Raf-1, c-Raf
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Vascular smooth muscle contraction
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Alcoholism
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00023  
EGF-EGFR-PLCG-ERK signaling pathway
N00024  
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  
CXCR-GNB/G-ERK signaling pathway
N00157  
KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
Disease
H01984  
Leopard syndrome
Drug target
Regorafenib (DG00720): 
Sorafenib (DG00713): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5894 (RAF1)
   04015 Rap1 signaling pathway
    5894 (RAF1)
   04010 MAPK signaling pathway
    5894 (RAF1)
   04012 ErbB signaling pathway
    5894 (RAF1)
   04370 VEGF signaling pathway
    5894 (RAF1)
   04371 Apelin signaling pathway
    5894 (RAF1)
   04630 Jak-STAT signaling pathway
    5894 (RAF1)
   04068 FoxO signaling pathway
    5894 (RAF1)
   04072 Phospholipase D signaling pathway
    5894 (RAF1)
   04071 Sphingolipid signaling pathway
    5894 (RAF1)
   04024 cAMP signaling pathway
    5894 (RAF1)
   04022 cGMP - PKG signaling pathway
    5894 (RAF1)
   04151 PI3K-Akt signaling pathway
    5894 (RAF1)
   04150 mTOR signaling pathway
    5894 (RAF1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5894 (RAF1)
  Cell growth and death
   04210 Apoptosis
    5894 (RAF1)
   04218 Cellular senescence
    5894 (RAF1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5894 (RAF1)
   04540 Gap junction
    5894 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5894 (RAF1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5894 (RAF1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    5894 (RAF1)
   04660 T cell receptor signaling pathway
    5894 (RAF1)
   04662 B cell receptor signaling pathway
    5894 (RAF1)
   04664 Fc epsilon RI signaling pathway
    5894 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    5894 (RAF1)
   04062 Chemokine signaling pathway
    5894 (RAF1)
  Endocrine system
   04910 Insulin signaling pathway
    5894 (RAF1)
   04912 GnRH signaling pathway
    5894 (RAF1)
   04915 Estrogen signaling pathway
    5894 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    5894 (RAF1)
   04917 Prolactin signaling pathway
    5894 (RAF1)
   04921 Oxytocin signaling pathway
    5894 (RAF1)
   04926 Relaxin signaling pathway
    5894 (RAF1)
   04919 Thyroid hormone signaling pathway
    5894 (RAF1)
   04916 Melanogenesis
    5894 (RAF1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5894 (RAF1)
  Nervous system
   04726 Serotonergic synapse
    5894 (RAF1)
   04720 Long-term potentiation
    5894 (RAF1)
   04730 Long-term depression
    5894 (RAF1)
   04722 Neurotrophin signaling pathway
    5894 (RAF1)
  Development
   04360 Axon guidance
    5894 (RAF1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5894 (RAF1)
   05230 Central carbon metabolism in cancer
    5894 (RAF1)
   05231 Choline metabolism in cancer
    5894 (RAF1)
   05206 MicroRNAs in cancer
    5894 (RAF1)
   05205 Proteoglycans in cancer
    5894 (RAF1)
   05210 Colorectal cancer
    5894 (RAF1)
   05212 Pancreatic cancer
    5894 (RAF1)
   05225 Hepatocellular carcinoma
    5894 (RAF1)
   05226 Gastric cancer
    5894 (RAF1)
   05214 Glioma
    5894 (RAF1)
   05221 Acute myeloid leukemia
    5894 (RAF1)
   05220 Chronic myeloid leukemia
    5894 (RAF1)
   05218 Melanoma
    5894 (RAF1)
   05211 Renal cell carcinoma
    5894 (RAF1)
   05219 Bladder cancer
    5894 (RAF1)
   05215 Prostate cancer
    5894 (RAF1)
   05213 Endometrial cancer
    5894 (RAF1)
   05224 Breast cancer
    5894 (RAF1)
   05223 Non-small cell lung cancer
    5894 (RAF1)
  Substance dependence
   05034 Alcoholism
    5894 (RAF1)
  Infectious diseases
   05152 Tuberculosis
    5894 (RAF1)
   05164 Influenza A
    5894 (RAF1)
   05161 Hepatitis B
    5894 (RAF1)
   05160 Hepatitis C
    5894 (RAF1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    5894 (RAF1)
   05165 Human papillomavirus infection
    5894 (RAF1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5894 (RAF1)
   01522 Endocrine resistance
    5894 (RAF1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     5894 (RAF1)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   5894 (RAF1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P04049(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
3p25.2
AA seq 648 aa AA seqDB search
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt NT seq  +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaa
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag

DBGET integrated database retrieval system