KEGG   Homo sapiens (human): 6328Help
Entry
6328              CDS       T01001                                 

Gene name
SCN3A, NAC3, Nav1.3
Definition
(RefSeq) sodium voltage-gated channel alpha subunit 3
  KO
K04836  voltage-gated sodium channel type III alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04742  Taste transduction
Drug target
Ajmaline: D00199
Aminobenzoic acid (DG00379): D02456 D02906 D02907
Amiodarone (DG00204): D00636 D02910
Aprindine (DG00199): D01326 D02969
Articaine (DG00805): D02991 D07468
Benzocaine: D00552
Bupivacaine (DG00801): D01450 D07552
Carbamazepine: D00252
Chloroprocaine (DG00800): D00732 D07678
Cibenzoline (DG00209): D01455 D03492
Cinchocaine (DG00297): D00733 D02220
Cocaine (DG00808): D00110 D02182
Disopyramide (DG00194): D00303 D00637
Encainide (DG00203): D03991 D07894
Eslicarbazepine (DG00848): D09215 D09612
Ethyl piperidinoacetylaminobenzoate: D01519
Etidocaine (DG00804): D00737 D04095
Flecainide (DG00201): D00638 D07962
Fosphenytoin (DG00847): D02096 D07595 D07993
Lacosamide: D07299
Lamotrigine: D00354
Levobupivacaine (DG00807): D01287 D08116
Lidocaine (DG00196): D00358 D02086 D08127
Lorajmine: D04774
Mephenytoin: D00375
Mepivacaine (DG00802): D00738 D08181
Mexiletine (DG00197): D00639 D08215
Oxcarbazepine: D00533
Oxetacaine (DG00299): D01152 D08311
Oxybuprocaine (DG00392): D01768 D08319
Phenytoin (DG00846): D00512 D02103
Pilsicainide (DG01257): D01554 D08377
Pirmenol (DG01381): D01785 D06517 D08394
Pramocaine (DG00300): D00739 D08407
Prilocaine (DG00803): D00553 D01243
Procainamide (DG00193): D00477 D08421
Procaine (DG00298): D00740 D08422
Propafenone (DG00200): D00640 D08435
Proxymetacaine (DG01145): D02098 D08448
Quinidine (DG00192): D00642 D00643 D02272 D08458 D08459
Ropivacaine (DG00806): D04048 D08490
Rufinamide: D05775
Sparteine (DG00195): D01041 D02239
Tetracaine (DG00296): D00551 D00741
Tocainide (DG00198): D02088 D06172
Topiramate: D00537
Zonisamide: D00538
p-Butylaminobenzoyldiethylaminoethyl hydrochloride: D01967
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Organismal Systems
  Sensory system
   04742 Taste transduction
    6328 (SCN3A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Na+ channel, SCN alpha, NaV1.x
   6328 (SCN3A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ion_trans Na_trans_cytopl Na_trans_assoc PKD_channel GPHH ATP-synt_B Lustrin_cystein IQ
Motif
Other DBs
NCBI-GeneID: 6328
NCBI-ProteinID: NP_008853
OMIM: 182391
HGNC: 10590
Ensembl: ENSG00000153253
Vega: OTTHUMG00000044171
Pharos: Q9NY46(Tclin)
UniProt: Q9NY46
Position
2q24.3
AA seq 2000 aa AA seqDB search
MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP
SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE
ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME
HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG
LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN
KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV
EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE
GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY
SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN
LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE
NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG
SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR
INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF
RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV
KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD
CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF
DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV
LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL
KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK
FEKDKPEKESKGKEVRENQK
NT seq 6003 nt NT seq  +upstreamnt  +downstreamnt
atggcacaggcactgttggtacccccaggacctgaaagcttccgcctttttactagagaa
tctcttgctgctatcgaaaaacgtgctgcagaagagaaagccaagaagcccaaaaaggaa
caagataatgatgatgagaacaaaccaaagccaaatagtgacttggaagctggaaagaac
cttccatttatttatggagacattcctccagagatggtgtcagagcccctggaggacctg
gatccctactatatcaataagaaaacttttatagtaatgaataaaggaaaggcaattttc
cgattcagtgccacctctgccttgtatattttaactccactaaaccctgttaggaaaatt
gctatcaagattttggtacattctttattcagcatgcttatcatgtgcactattttgacc
aactgtgtatttatgaccttgagcaaccctcctgactggacaaagaatgtagagtacaca
ttcactggaatctatacctttgagtcacttataaaaatcttggcaagagggttttgctta
gaagattttacgtttcttcgtgatccatggaactggctggatttcagtgtcattgtgatg
gcatatgtgacagagtttgtggacctgggcaatgtctcagcgttgagaacattcagagtt
ctccgagcactgaaaacaatttcagtcattccaggtttaaagaccattgtgggggccctg
atccagtcggtaaagaagctttctgatgtgatgatcctgactgtgttctgtctgagcgtg
tttgctctcattgggctgcagctgttcatgggcaatctgaggaataaatgtttgcagtgg
cccccaagcgattctgcttttgaaaccaacaccacttcctactttaatggcacaatggat
tcaaatgggacatttgttaatgtaacaatgagcacatttaactggaaggattacattgga
gatgacagtcacttttatgttttggatgggcaaaaagaccctttactctgtggaaatggc
tcagatgcaggccagtgtccagaaggatacatctgtgtgaaggctggtcgaaaccccaac
tatggctacacaagctttgacacctttagctgggctttcctgtctctatttcgactcatg
actcaagactactgggaaaatctttaccagttgacattacgtgctgctgggaaaacatac
atgatattttttgtcctggtcattttcttgggctcattttatttggtgaatttgatcctg
gctgtggtggccatggcctatgaggagcagaatcaggccaccttggaagaagcagaacaa
aaagaggccgaatttcagcagatgctcgaacagcttaaaaagcaacaggaagaagctcag
gcagttgcggcagcatcagctgcttcaagagatttcagtggaataggtgggttaggagag
ctgttggaaagttcttcagaagcatcaaagttgagttccaaaagtgctaaagaatggagg
aaccgaaggaagaaaagaagacagagagagcaccttgaaggaaacaacaaaggagagaga
gacagctttcccaaatccgaatctgaagacagcgtcaaaagaagcagcttccttttctcc
atggatggaaacagactgaccagtgacaaaaaattctgctcccctcatcagtctctcttg
agtatccgtggctccctgttttccccaagacgcaatagcaaaacaagcattttcagtttc
agaggtcgggcaaaggatgttggatctgaaaatgactttgctgatgatgaacacagcaca
tttgaagacagcgaaagcaggagagactcactgtttgtgccgcacagacatggagagcga
cgcaacagtaacgttagtcaggccagtatgtcatccaggatggtgccagggcttccagca
aatgggaagatgcacagcactgtggattgcaatggtgtggtttccttggtgggtggacct
tcagctctaacgtcacctactggacaacttcccccagagggcaccaccacagaaacggaa
gtcagaaagagaaggttaagctcttaccagatttcaatggagatgctggaggattcctct
ggaaggcaaagagccgtgagcatagccagcattctgaccaacacaatggaagaacttgaa
gaatctagacagaaatgtccgccatgctggtatagatttgccaatgtgttcttgatctgg
gactgctgtgatgcatggttaaaagtaaaacatcttgtgaatttaattgttatggatcca
tttgttgatcttgccatcactatttgcattgtcttaaataccctctttatggccatggag
cactaccccatgactgagcaattcagtagtgtgttgactgtaggaaacctggtctttact
gggattttcacagcagaaatggttctcaagatcattgccatggatccttattactatttc
caagaaggctggaatatctttgatggaattattgtcagcctcagtttaatggagcttggt
ctgtcaaatgtggagggattgtctgtactgcgatcattcagactgcttagagttttcaag
ttggcaaaatcctggcccacactaaatatgctaattaagatcattggcaattctgtgggg
gctctaggaaacctcaccttggtgttggccatcatcgtcttcatttttgctgtggtcggc
atgcagctctttggtaagagctacaaagaatgtgtctgcaagatcaatgatgactgtacg
ctcccacggtggcacatgaacgacttcttccactccttcctgattgtgttccgcgtgctg
tgtggagagtggatagagaccatgtgggactgtatggaggtcgctggccaaaccatgtgc
cttattgttttcatgttggtcatggtcattggaaaccttgtggttctgaacctctttctg
gccttattgttgagttcatttagctcagacaaccttgctgctactgatgatgacaatgaa
atgaataatctgcagattgcagtaggaagaatgcaaaagggaattgattatgtgaaaaat
aagatgcgggagtgtttccaaaaagccttttttagaaagccaaaagttatagaaatccat
gaaggcaataagatagacagctgcatgtccaataatactggaattgaaataagcaaagag
cttaattatcttagagatgggaatggaaccaccagtggtgtaggtactggaagcagtgtt
gaaaaatacgtaatcgatgaaaatgattatatgtcattcataaacaaccccagcctcacc
gtcacagtgccaattgctgttggagagtctgactttgaaaacttaaatactgaagagttc
agcagtgagtcagaactagaagaaagcaaagagaaattaaatgcaaccagctcatctgaa
ggaagcacagttgatgttgttctaccccgagaaggtgaacaagctgaaactgaacccgaa
gaagaccttaaaccggaagcttgttttactgaaggatgtattaaaaagtttccattctgt
caagtaagtacagaagaaggcaaagggaagatctggtggaatcttcgaaaaacctgctac
agtattgttgagcacaactggtttgagactttcattgtgttcatgatccttctcagtagt
ggtgcattggcctttgaagatatatacattgaacagcgaaagactatcaaaaccatgcta
gaatatgctgacaaagtctttacctatatattcattctggaaatgcttctcaaatgggtt
gcttatggatttcaaacatatttcactaatgcctggtgctggctagatttcttgatcgtt
gatgtttctttggttagcctggtagccaatgctcttggctactcagaactcggtgccatc
aaatcattacggacattaagagctttaagacctctaagagccttatcccggtttgaaggc
atgagggtggttgtgaatgctcttgttggagcaattccctctatcatgaatgtgctgttg
gtctgtctcatcttctggttgatctttagcatcatgggtgtgaatttgtttgctggcaag
ttctaccactgtgttaacatgacaacgggtaacatgtttgacattagtgatgttaacaat
ttgagtgactgtcaggctcttggcaagcaagctcggtggaaaaacgtgaaagtaaacttt
gataatgttggcgctggctatcttgcactgcttcaagtggccacatttaaaggctggatg
gatattatgtatgcagctgttgattcacgagatgttaaacttcagcctgtatatgaagaa
aatctgtacatgtatttatactttgtcatctttatcatctttgggtcattcttcactctg
aatctattcattggtgtcatcatagataacttcaaccagcagaaaaagaagtttggaggt
caagacatctttatgacagaggaacagaaaaaatattacaatgcaatgaagaaacttgga
tccaagaaacctcagaaacccatacctcgcccagcaaacaaattccaaggaatggtcttt
gattttgtaaccagacaagtctttgatatcagcatcatgatcctcatctgcctcaacatg
gtcaccatgatggtggaaacggatgaccagggcaaatacatgaccctagttttgtcccgg
atcaacctagtgttcattgttctgttcactggagaatttgtgctgaagctcgtctccctc
agacactactacttcactataggctggaacatctttgactttgtggtggtgattctctcc
attgtaggtatgtttctggctgagatgatagaaaagtattttgtgtcccctaccttgttc
cgagtgatccgtcttgccaggattggccgaatcctacgtctgatcaaaggagcaaagggg
atccgcacgctgctctttgctttgatgatgtcccttcctgcgttgtttaacatcggcctc
ctgctcttcctggtcatgtttatctatgccatctttgggatgtccaactttgcctatgtt
aaaaaggaagctggaattgatgacatgttcaactttgagacctttggcaacagcatgatc
tgcttgttccaaattacaacctctgctggctgggatggattgctagcacctattcttaat
agtgcaccacccgactgtgaccctgacacaattcaccctggcagctcagttaagggagac
tgtgggaacccatctgttgggattttcttttttgtcagttacatcatcatatccttcctg
gttgtggtgaacatgtacatcgcggtcatcctggagaacttcagtgttgctactgaagaa
agtgcagagcccctgagtgaggatgactttgagatgttctatgaggtttgggaaaagttt
gatcccgatgcgacccagtttatagagttctctaaactctctgattttgcagctgccctg
gatcctcctcttctcatagcaaaacccaacaaagtccagcttattgccatggatctgccc
atggtcagtggtgaccggatccactgtcttgatattttatttgcctttacaaagcgtgtt
ttgggtgagagtggagagatggatgcccttcgaatacagatggaagacaggtttatggca
tcaaacccctccaaagtctcttatgagcctattacaaccactttgaaacgtaaacaagag
gaggtgtctgccgctatcattcagcgtaatttcagatgttatcttttaaagcaaaggtta
aaaaatatatcaagtaactataacaaagaggcaattaaagggaggattgacttacctata
aaacaagacatgattattgacaaactaaatgggaactccactccagaaaaaacagatggg
agttcctctaccacctctcctccttcctatgatagtgtaacaaaaccagacaaggaaaag
tttgagaaagacaaaccagaaaaagaaagcaaaggaaaagaggtcagagaaaatcaaaag
taa

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