KEGG T01001: 6335

Homo sapiens (human): 6335

Entry

6335 CDS T01001

Gene name

SCN9A, ETHA, FEB3B, GEFSP7, NE-NA, NENA, Nav1.7, PN1, SFNP

Definition

sodium channel, voltage-gated, type IX, alpha subunit

Orthology

K04841

voltage-gated sodium channel type IX alpha

Organism

hsa Homo sapiens (human)

Disease

H00771	Inherited erythromelalgia (IEM)
H00772	Paroxysmal extreme pain disorder (PEPD)
H00774	Nav1.7-associated congenital insensitivity to pain (CIP)
H00783	Febrile seizures

Drug target

Quinidine:

D00642 D00643 D02272 D08458 D08459

Procainamide:

Disopyramide:

Ajmaline:

Lidocaine:

Mexiletine:

Tocainide:

Aprindine:

Propafenone:

Flecainide:

Encainide:

Bunaftine:

Moracizine:

Cibenzoline:

Tetracaine:

Benzocaine:

Cinchocaine:

Procaine:

Chloroprocaine:

Bupivacaine:

Mepivacaine:

Ropivacaine:

Levobupivacaine:

Cocaine:

Dyclonine:

Phenytoin:

Mephenytoin:

Fosphenytoin:

Carbamazepine:

Oxcarbazepine:

Eslicarbazepine:

Lamotrigine:

Topiramate:

Zonisamide:

Ambroxol:

Other:

D01554 D01785 D02098 D06517 D08048 D08377 D08394

Class

SSDB

Motif

Pfam:

Ion_trans Na_trans_assoc DUF3451 PKD_channel IQ

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

2q24

AA seq 1977 aa
MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP
FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI
KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE
FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE
LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR
KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR
GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCS
SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWI
KFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEM
VLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPT
LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN
DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF
SSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN
TKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPI
APGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEP
EACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAF
EDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV
TLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDN
VGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNL
FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDL
VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRH
YYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR
TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICL
FQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVV
VNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDP
PLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSAN
PSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKD
MAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK

NT seq 5934 nt +upstreamnt +downstreamnt
atggcaatgttgcctcccccaggacctcagagctttgtccatttcacaaaacagtctctt
gccctcattgaacaacgcattgctgaaagaaaatcaaaggaacccaaagaagaaaagaaa
gatgatgatgaagaagccccaaagccaagcagtgacttggaagctggcaaacagctgccc
ttcatctatggggacattcctcccggcatggtgtcagagcccctggaggacttggacccc
tactatgcagacaaaaagactttcatagtattgaacaaagggaaaacaatcttccgtttc
aatgccacacctgctttatatatgctttctcctttcagtcctctaagaagaatatctatt
aagattttagtacactccttattcagcatgctcatcatgtgcactattctgacaaactgc
atatttatgaccatgaataacccaccggactggaccaaaaatgtcgagtacacttttact
ggaatatatacttttgaatcacttgtaaaaatccttgcaagaggcttctgtgtaggagaa
ttcacttttcttcgtgacccgtggaactggctggattttgtcgtcattgtttttgcgtat
ttaacagaatttgtaaacctaggcaatgtttcagctcttcgaactttcagagtattgaga
gctttgaaaactatttctgtaatcccaggcctgaagacaattgtaggggctttgatccag
tcagtgaagaagctttctgatgtcatgatcctgactgtgttctgtctgagtgtgtttgca
ctaattggactacagctgttcatgggaaacctgaagcataaatgttttcgaaattcactt
gaaaataatgaaacattagaaagcataatgaataccctagagagtgaagaagactttaga
aaatatttttattacttggaaggatccaaagatgctctcctttgtggtttcagcacagat
tcaggtcagtgtccagaggggtacacctgtgtgaaaattggcagaaaccctgattatggc
tacacgagctttgacactttcagctgggccttcttagccttgtttaggctaatgacccaa
gattactgggaaaacctttaccaacagacgctgcgtgctgctggcaaaacctacatgatc
ttctttgtcgtagtgattttcctgggctccttttatctaataaacttgatcctggctgtg
gttgccatggcatatgaagaacagaaccaggcaaacattgaagaagctaaacagaaagaa
ttagaatttcaacagatgttagaccgtcttaaaaaagagcaagaagaagctgaggcaatt
gcagcggcagcggctgaatatacaagtattaggagaagcagaattatgggcctctcagag
agttcttctgaaacatccaaactgagctctaaaagtgctaaagaaagaagaaacagaaga
aagaaaaagaatcaaaagaagctctccagtggagaggaaaagggagatgctgagaaattg
tcgaaatcagaatcagaggacagcatcagaagaaaaagtttccaccttggtgtcgaaggg
cataggcgagcacatgaaaagaggttgtctacccccaatcagtcaccactcagcattcgt
ggctccttgttttctgcaaggcgaagcagcagaacaagtctttttagtttcaaaggcaga
ggaagagatataggatctgagactgaatttgccgatgatgagcacagcatttttggagac
aatgagagcagaaggggctcactgtttgtgccccacagaccccaggagcgacgcagcagt
aacatcagccaagccagtaggtccccaccaatgctgccggtgaacgggaaaatgcacagt
gctgtggactgcaacggtgtggtctccctggttgatggacgctcagccctcatgctcccc
aatggacagcttctgccagagggcacgaccaatcaaatacacaagaaaaggcgttgtagt
tcctatctcctttcagaggatatgctgaatgatcccaacctcagacagagagcaatgagt
agagcaagcatattaacaaacactgtggaagaacttgaagagtccagacaaaaatgtcca
ccttggtggtacagatttgcacacaaattcttgatctggaattgctctccatattggata
aaattcaaaaagtgtatctattttattgtaatggatccttttgtagatcttgcaattacc
atttgcatagttttaaacacattatttatggctatggaacaccacccaatgactgaggaa
ttcaaaaatgtacttgctataggaaatttggtctttactggaatctttgcagctgaaatg
gtattaaaactgattgccatggatccatatgagtatttccaagtaggctggaatattttt
gacagccttattgtgactttaagtttagtggagctctttctagcagatgtggaaggattg
tcagttctgcgatcattcagactgctccgagtcttcaagttggcaaaatcctggccaaca
ttgaacatgctgattaagatcattggtaactcagtaggggctctaggtaacctcacctta
gtgttggccatcatcgtcttcatttttgctgtggtcggcatgcagctctttggtaagagc
tacaaagaatgtgtctgcaagatcaatgatgactgtacgctcccacggtggcacatgaac
gacttcttccactccttcctgattgtgttccgcgtgctgtgtggagagtggatagagacc
atgtgggactgtatggaggtcgctggtcaagctatgtgccttattgtttacatgatggtc
atggtcattggaaacctggtggtcctaaacctatttctggccttattattgagctcattt
agttcagacaatcttacagcaattgaagaagaccctgatgcaaacaacctccagattgca
gtgactagaattaaaaagggaataaattatgtgaaacaaaccttacgtgaatttattcta
aaagcattttccaaaaagccaaagatttccagggagataagacaagcagaagatctgaat
actaagaaggaaaactatatttctaaccatacacttgctgaaatgagcaaaggtcacaat
ttcctcaaggaaaaagataaaatcagtggttttggaagcagcgtggacaaacacttgatg
gaagacagtgatggtcaatcatttattcacaatcccagcctcacagtgacagtgccaatt
gcacctggggaatccgatttggaaaatatgaatgctgaggaacttagcagtgattcggat
agtgaatacagcaaagtgagattaaaccggtcaagctcctcagagtgcagcacagttgat
aaccctttgcctggagaaggagaagaagcagaggctgaacctatgaattccgatgagcca
gaggcctgtttcacagatggttgtgtacggaggttctcatgctgccaagttaacatagag
tcagggaaaggaaaaatctggtggaacatcaggaaaacctgctacaagattgttgaacac
agttggtttgaaagcttcattgtcctcatgatcctgctcagcagtggtgccctggctttt
gaagatatttatattgaaaggaaaaagaccattaagattatcctggagtatgcagacaag
atcttcacttacatcttcattctggaaatgcttctaaaatggatagcatatggttataaa
acatatttcaccaatgcctggtgttggctggatttcctaattgttgatgtttctttggtt
actttagtggcaaacactcttggctactcagatcttggccccattaaatcccttcggaca
ctgagagctttaagacctctaagagccttatctagatttgaaggaatgagggtcgttgtg
aatgcactcataggagcaattccttccatcatgaatgtgctacttgtgtgtcttatattc
tggctgatattcagcatcatgggagtaaatttgtttgctggcaagttctatgagtgtatt
aacaccacagatgggtcacggtttcctgcaagtcaagttccaaatcgttccgaatgtttt
gcccttatgaatgttagtcaaaatgtgcgatggaaaaacctgaaagtgaactttgataat
gtcggacttggttacctatctctgcttcaagttgcaacttttaagggatggacgattatt
atgtatgcagcagtggattctgttaatgtagacaagcagcccaaatatgaatatagcctc
tacatgtatatttattttgtcgtctttatcatctttgggtcattcttcactttgaacttg
ttcattggtgtcatcatagataatttcaaccaacagaaaaagaagcttggaggtcaagac
atctttatgacagaagaacagaagaaatactataatgcaatgaaaaagctggggtccaag
aagccacaaaagccaattcctcgaccagggaacaaaatccaaggatgtatatttgaccta
gtgacaaatcaagcctttgatattagtatcatggttcttatctgtctcaacatggtaacc
atgatggtagaaaaggagggtcaaagtcaacatatgactgaagttttatattggataaat
gtggtttttataatccttttcactggagaatgtgtgctaaaactgatctccctcagacac
tactacttcactgtaggatggaatatttttgattttgtggttgtgattatctccattgta
ggtatgtttctagctgatttgattgaaacgtattttgtgtcccctaccctgttccgagtg
atccgtcttgccaggattggccgaatcctacgtctagtcaaaggagcaaaggggatccgc
acgctgctctttgctttgatgatgtcccttcctgcgttgtttaacatcggcctcctgctc
ttcctggtcatgttcatctacgccatctttggaatgtccaactttgcctatgttaaaaag
gaagatggaattaatgacatgttcaattttgagacctttggcaacagtatgatttgcctg
ttccaaattacaacctctgctggctgggatggattgctagcacctattcttaacagtaag
ccacccgactgtgacccaaaaaaagttcatcctggaagttcagttgaaggagactgtggt
aacccatctgttggaatattctactttgttagttatatcatcatatccttcctggttgtg
gtgaacatgtacattgcagtcatactggagaattttagtgttgccactgaagaaagtact
gaacctctgagtgaggatgactttgagatgttctatgaggtttgggagaagtttgatccc
gatgcgacccagtttatagagttctctaaactctctgattttgcagctgccctggatcct
cctcttctcatagcaaaacccaacaaagtccagctcattgccatggatctgcccatggtt
agtggtgaccggatccattgtcttgacatcttatttgcttttacaaagcgtgttttgggt
gagagtggggagatggattctcttcgttcacagatggaagaaaggttcatgtctgcaaat
ccttccaaagtgtcctatgaacccatcacaaccacactaaaacggaaacaagaggatgtg
tctgctactgtcattcagcgtgcttatagacgttaccgcttaaggcaaaatgtcaaaaat
atatcaagtatatacataaaagatggagacagagatgatgatttactcaataaaaaagat
atggcttttgataatgttaatgagaactcaagtccagaaaaaacagatgccacttcatcc
accacctctccaccttcatatgatagtgtaacaaagccagacaaagagaaatatgaacaa
gacagaacagaaaaggaagacaaagggaaagacagcaaggaaagcaaaaaatag

All links

Ontology (5)   
   KEGG BRITE (5)   
Disease (11)   
   KEGG DISEASE (4)   
   OMIM (7)   
Drug (67)   
   KEGG DRUG (67)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (9)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
Protein domain (5)   
   Pfam (5)   
All databases (134)   

Download RDF

DBGET integrated database retrieval system