KEGG T01001: 6548

Homo sapiens (human): 6548

Entry

6548 CDS T01001

Gene name

SLC9A1, APNH, NHE-1, NHE1

Definition

solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

Orthology

K05742

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04260	Cardiac muscle contraction
hsa04810	Regulation of actin cytoskeleton
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04976	Bile secretion
hsa05205	Proteoglycans in cancer

Drug target

Other:

D03406 D09036

Class

Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:hsa04810]
Organismal Systems; Circulatory system; Cardiac muscle contraction [PATH:hsa04260]
Organismal Systems; Digestive system; Salivary secretion [PATH:hsa04970]
Organismal Systems; Digestive system; Gastric acid secretion [PATH:hsa04971]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:hsa04972]
Organismal Systems; Digestive system; Bile secretion [PATH:hsa04976]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:hsa05205]

SSDB

Motif

Pfam:

Na_H_Exchanger OprF Toprim_3

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2YGG 2BEC 2L0E 2E30 1Y4E

Position

1p36.1-p35

AA seq 815 aa
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDV
TTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFV
VALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITID
PASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTP
APSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ

NT seq 2448 nt +upstreamnt +downstreamnt
atggttctgcggtctggcatctgtggcctctctccacatcggatcttcccttccttactc
gtggtggttgctttggtggggctgctgcctgttctcaggagccatggcctccagctcagc
ccaactgccagcaccattcgaagctcagagccaccacgagaacgctcgattggggatgtc
accaccgctccaccggaggtcaccccagagagccgccctgttaatcattccgtcactgat
catggcatgaagccgcgcaaggcctttccagtcctgggcatcgactacacacacgtgcgc
acccccttcgagatctccctctggatccttctggcctgcctcatgaagataggtttccat
gtgatccccactatctcaagcatcgtcccggagagctgcctgctgatcgtggtggggctg
ctggtggggggcctgatcaagggtgtaggcgagacaccccccttcctgcagtccgacgtc
ttcttcctcttcctgctgccgcccatcatcctggatgcgggctacttcctgccactgcgg
cagttcacagaaaacctgggcaccatcctgatctttgccgtggtgggcacgctgtggaac
gccttcttcctgggcggcctcatgtacgccgtgtgcctggtgggcggtgagcagatcaac
aacatcggcctcctggacaacctgctcttcggcagcatcatctcggccgtggaccccgtg
gcggttctggctgtctttgaggaaattcacatcaatgagctgctgcacatccttgttttt
ggggagtccttgctcaatgacgccgtcactgtggtcctgtatcacctctttgaggagttt
gccaactacgaacacgtgggcatcgtggacatcttcctcggcttcctgagcttcttcgtg
gtggccctgggcggggtgcttgtgggcgtggtctacggggtcatcgcagccttcacctcc
cgatttacctcccacatccgggtcatcgagccgctcttcgtcttcctctacagctacatg
gcctacttgtcagccgagctcttccacctgtcaggcatcatggcgctcatagcctcagga
gtggtgatgcgcccctatgtggaggccaacatctcccacaagtcccacaccaccatcaaa
tacttcctgaagatgtggagcagcgtcagcgagaccctcatcttcatcttcctcggcgtc
tccacggtggccggctcccaccactggaactggaccttcgtcatcagcaccctgctcttc
tgcctcatcgcccgcgtgctgggggtgctgggcctgacctggttcatcaacaagttccgt
atcgtgaagctgacccccaaggaccagttcatcatcgcctatgggggcctgcgaggggcc
atcgccttctctctgggctacctcctggacaagaagcacttccccatgtgtgacctgttc
ctcactgccatcatcactgtcatcttcttcaccgtctttgtgcagggcatgaccattcgg
cccctggtagacctgttggctgtgaagaaaaagcaagagacgaagcgctccatcaacgaa
gagatccacacacagttcctggaccaccttctgacaggcatcgaagacatctgtggccac
tacggtcaccaccactggaaggacaagctcaaccggtttaataagaaatatgtgaagaag
tgtctgatagctggcgagcgctccaaggagccccagctcattgccttctaccacaagatg
gagatgaagcaggccatcgagctggtggagagcgggggcatgggcaagatcccctctgcc
gtctccaccgtctccatgcagaacatccaccccaagtccctgccttccgagcgcatcctg
ccagcactgtccaaggacaaggaggaggagatccgcaaaatcctgaggaacaacttgcag
aagaccaggcagcggctgcggtcctacaacagacacacgctggtggcagacccctacgag
gaagcctggaaccagatgctgctccggaggcagaaggcccggcagctggagcagaagatc
aacaactacctgacggtgccagcccacaagctggactcacccaccatgtctcgggcccgc
atcggctcagacccactggcctatgagccgaaggaggacctgcctgtcatcaccatcgac
ccggcttccccgcagtcacccgagtctgtggacctggtgaatgaagagctgaagggcaaa
gtcttagggttgagccgggatcctgcaaaggtggctgaggaggacgaggacgacgatggg
ggcatcatgatgcggagcaaggagacttcgtccccaggaaccgacgatgtcttcaccccc
gcgcccagtgacagccccagctcccagaggatacagcgctgcctcagtgacccaggccca
caccctgagcctggggagggagaaccgttcttccccaaggggcagtaa

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (27)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (74)   
   RefSeq(nuc) (2)   
   GenBank (36)   
   EMBL (36)   
3D Structure (5)   
   PDB (5)   
Protein domain (3)   
   Pfam (3)   
All databases (133)   

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