KEGG T01001: 6558

Homo sapiens (human): 6558

Entry

6558 CDS T01001

Gene name

SLC12A2, BSC, BSC2, NKCC1

Definition

solute carrier family 12 (sodium/potassium/chloride transporters), member 2

Orthology

K10951

solute carrier family 12 (sodium/potassium/chloride transporter), member 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04970	Salivary secretion
hsa04972	Pancreatic secretion
hsa05110	Vibrio cholerae infection

Drug target

Furosemide:

Bumetanide:

Piretanide:

Torasemide:

Etacrynic acid:

Muzolimine:

Other:

Class

Organismal Systems; Digestive system; Salivary secretion [PATH:hsa04970]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:hsa04972]
Human Diseases; Infectious diseases; Vibrio cholerae infection [PATH:hsa05110]

SSDB

Motif

Pfam:

AA_permease AA_permease_N AA_permease_2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

5q23.3

AA seq 1212 aa
MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEG
PAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADG
EASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLS
EGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLR
PSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIW
GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL
GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVIL
LGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPD
FREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV
GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFT
PLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFL
IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA
ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV
EDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQA
KYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDV
DMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKS
DLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQG
KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFR
IDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELE
LYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLV
RGNHQSVLTFYS

NT seq 3639 nt +upstreamnt +downstreamnt
atggagccgcggcccacggcgccctcctccggcgccccgggactggccggggtcggggag
acgccgtcagccgctgcgctggccgcagccagggtggaactgcccggcacggctgtgccc
tcggtgccggaggatgctgcgcccgcgagccgggacggcggcggggtccgcgatgagggc
cccgcggcggccggggacgggctgggcagacccttggggcccaccccgagccagagccgt
ttccaggtggacctggtttccgagaacgccgggcgggccgctgctgcggcggcggcggcg
gcggcggcagcggcggcggctggtgctggggcgggggccaagcagacccccgcggacggg
gaagccagcggcgagagcgagccggctaaaggcagcgaggaagccaagggccgcttccgc
gtgaacttcgtggacccagctgcctcctcgtcggctgaagacagcctgtcagatgctgcc
ggggtcggagtcgacgggcccaacgtgagcttccagaacggcggggacacggtgctgagc
gagggcagcagcctgcactccggcggcggcggcggcagtgggcaccaccagcactactat
tatgatacccacaccaacacctactacctgcgcaccttcggccacaacaccatggacgct
gtgcccaggatcgatcactaccggcacacagccgcgcagctgggcgagaagctgctccgg
cctagcctggcggagctccacgacgagctggaaaaggaaccttttgaggatggctttgca
aatggggaagaaagtactccaaccagagatgctgtggtcacgtatactgcagaaagtaaa
ggagtcgtgaagtttggctggatcaagggtgtattagtacgttgtatgttaaacatttgg
ggtgtgatgcttttcattagattgtcatggattgtgggtcaagctggaataggtctatca
gtccttgtaataatgatggccactgttgtgacaactatcacaggattgtctacttcagca
atagcaactaatggatttgtaagaggaggaggagcatattatttaatatctagaagtcta
gggccagaatttggtggtgcaattggtctaatcttcgcctttgccaacgctgttgcagtt
gctatgtatgtggttggatttgcagaaaccgtggtggagttgcttaaggaacattccata
cttatgatagatgaaatcaatgatatccgaattattggagccattacagtcgtgattctt
ttaggtatctcagtagctggaatggagtgggaagcaaaagctcagattgttcttttggtg
atcctacttcttgctattggtgatttcgtcataggaacatttatcccactggagagcaag
aagccaaaagggttttttggttataaatctgaaatatttaatgagaactttgggcccgat
tttcgagaggaagagactttcttttctgtatttgccatcttttttcctgctgcaactggt
attctggctggagcaaatatctcaggtgatcttgcagatcctcagtcagccatacccaaa
ggaacactcctagccattttaattactacattggtttacgtaggaattgcagtatctgta
ggttcttgtgttgttcgagatgccactggaaacgttaatgacactatcgtaacagagcta
acaaactgtacttctgcagcctgcaaattaaactttgatttttcatcttgtgaaagcagt
ccttgttcctatggcctaatgaacaacttccaggtaatgagtatggtgtcaggatttaca
ccactaatttctgcaggtatattttcagccactctttcttcagcattagcatccctagtg
agtgctcccaaaatatttcaggctctatgtaaggacaacatctacccagctttccagatg
tttgctaaaggttatgggaaaaataatgaacctcttcgtggctacatcttaacattctta
attgcacttggattcatcttaattgctgaactgaatgttattgcaccaattatctcaaac
ttcttccttgcatcatatgcattgatcaatttttcagtattccatgcatcacttgcaaaa
tctccaggatggcgtcctgcattcaaatactacaacatgtggatatcacttcttggagca
attctttgttgcatagtaatgttcgtcattaactggtgggctgcattgctaacatatgtg
atagtccttgggctgtatatttatgttacctacaaaaaaccagatgtgaattggggatcc
tctacacaagccctgacttacctgaatgcactgcagcattcaattcgtctttctggagtg
gaagaccacgtgaaaaactttaggccacagtgtcttgttatgacaggtgctccaaactca
cgtccagctttacttcatcttgttcatgatttcacaaaaaatgttggtttgatgatctgt
ggccatgtacatatgggtcctcgaagacaagccatgaaagagatgtccatcgatcaagcc
aaatatcagcgatggcttattaagaacaaaatgaaggcattttatgctccagtacatgca
gatgacttgagagaaggtgcacagtatttgatgcaggctgctggtcttggtcgtatgaag
ccaaacacacttgtccttggatttaagaaagattggttgcaagcagatatgagggatgtg
gatatgtatataaacttatttcatgatgcttttgacatacaatatggagtagtggttatt
cgcctaaaagaaggtctggatatatctcatcttcaaggacaagaagaattattgtcatca
caagagaaatctcctggcaccaaggatgtggtagtaagtgtggaatatagtaaaaagtcc
gatttagatacttccaaaccactcagtgaaaaaccaattacacacaaagttgaggaagag
gatggcaagactgcaactcaaccactgttgaaaaaagaatccaaaggccctattgtgcct
ttaaatgtagctgaccaaaagcttcttgaagctagtacacagtttcagaaaaaacaagga
aagaatactattgatgtctggtggctttttgatgatggaggtttgaccttattgatacct
taccttctgacgaccaagaaaaaatggaaagactgtaagatcagagtattcattggtgga
aagataaacagaatagaccatgaccggagagcgatggctactttgcttagcaagttccgg
atagacttttctgatatcatggttctaggagatatcaataccaaaccaaagaaagaaaat
attatagcttttgaggaaatcattgagccatacagacttcatgaagatgataaagagcaa
gatattgcagataaaatgaaagaagatgaaccatggcgaataacagataatgagcttgaa
ctttataagaccaagacataccggcagatcaggttaaatgagttattaaaggaacattca
agcacagctaatattattgtcatgagtctcccagttgcacgaaaaggtgctgtgtctagt
gctctctacatggcatggttagaagctctatctaaggacctaccaccaatcctcctagtt
cgtgggaatcatcagagtgtccttaccttctattcataa

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (13)   
   KEGG DRUG (13)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (3)   
   RefSeq(pep) (2)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
Protein domain (3)   
   Pfam (3)   
All databases (79)   

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