KEGG T01001: 6608

Homo sapiens (human): 6608

Entry

6608 CDS T01001

Gene name

SMO, CRJS, FZD11, Gx, SMOH

Definition

(RefSeq) smoothened, frizzled class receptor

K06226

smoothened

Organism

hsa Homo sapiens (human)

Pathway

hsa04340	Hedgehog signaling pathway
hsa04360	Axon guidance
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05217	Basal cell carcinoma

Module

hsa_M00678

Hedgehog signaling

Network

N00010	Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017	Mutation-activated SMO to Hedgehog signaling pathway
N00062	Hedgehog signaling pathway

Disease

H00039	Basal cell carcinoma
H01556	Meningioma
H01667	Medulloblastoma

Drug target

Glasdegib:

Saridegib (DG01274):

Sonidegib (DG01854):

Taladegib:

Vismodegib:

Brite

KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
  Signal transduction
   04340 Hedgehog signaling pathway
    6608 (SMO)
Organismal Systems
  Development
   04360 Axon guidance
    6608 (SMO)
Human Diseases
  Cancers
   05200 Pathways in cancer
    6608 (SMO)
   05205 Proteoglycans in cancer
    6608 (SMO)
   05217 Basal cell carcinoma
    6608 (SMO)
G protein-coupled receptors [BR:hsa04030]
Others
  Wnt signaling
   Frizzled / Smoothened family
    6608 (SMO)

SSDB

Motif

Pfam:

Frizzled Fz Dicty_CAR

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q99835(Tclin)

UniProt:

Q99835

Position

7q32.1

AA seq 787 aa
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF

NT seq 2364 nt +upstreamnt +downstreamnt
atggccgctgcccgcccagcgcgggggccggagctcccgctcctggggctgctgctgctg
ctgctgctgggggacccgggccggggggcggcctcgagcgggaacgcgaccgggcctggg
cctcggagcgcgggcgggagcgcgaggaggagcgcggcggtgactggccctccgccgccg
ctgagccactgcggccgggctgccccctgcgagccgctgcgctacaacgtgtgcctgggc
tcggtgctgccctacggggccacctccacactgctggccggagactcggactcccaggag
gaagcgcacggcaagctcgtgctctggtcgggcctccggaatgccccccgctgctgggca
gtgatccagcccctgctgtgtgccgtatacatgcccaagtgtgagaatgaccgggtggag
ctgcccagccgtaccctctgccaggccacccgaggcccctgtgccatcgtggagagggag
cggggctggcctgacttcctgcgctgcactcctgaccgcttccctgaaggctgcacgaat
gaggtgcagaacatcaagttcaacagttcaggccagtgcgaagtgcccttggttcggaca
gacaaccccaagagctggtacgaggacgtggagggctgcggcatccagtgccagaacccg
ctcttcacagaggctgagcaccaggacatgcacagctacatcgcggccttcggggccgtc
acgggcctctgcacgctcttcaccctggccacattcgtggctgactggcggaactcgaat
cgctaccctgctgttattctcttctacgtcaatgcgtgcttctttgtgggcagcattggc
tggctggcccagttcatggatggtgcccgccgagagatcgtctgccgtgcagatggcacc
atgaggcttggggagcccacctccaatgagactctgtcctgcgtcatcatctttgtcatc
gtgtactacgccctgatggctggtgtggtttggtttgtggtcctcacctatgcctggcac
acttccttcaaagccctgggcaccacctaccagcctctctcgggcaagacctcctacttc
cacctgctcacctggtcactcccctttgtcctcactgtggcaatccttgctgtggcgcag
gtggatggggactctgtgagtgggatttgttttgtgggctacaagaactaccgataccgt
gcgggcttcgtgctggccccaatcggcctggtgctcatcgtgggaggctacttcctcatc
cgaggagtcatgactctgttctccatcaagagcaaccaccccgggctgctgagtgagaag
gctgccagcaagatcaacgagaccatgctgcgcctgggcatttttggcttcctggccttt
ggctttgtgctcattaccttcagctgccacttctacgacttcttcaaccaggctgagtgg
gagcgcagcttccgggactatgtgctatgtcaggccaatgtgaccatcgggctgcccacc
aagcagcccatccctgactgtgagatcaagaatcgcccgagccttctggtggagaagatc
aacctgtttgccatgtttggaactggcatcgccatgagcacctgggtctggaccaaggcc
acgctgctcatctggaggcgtacctggtgcaggttgactgggcagagtgacgatgagcca
aagcggatcaagaagagcaagatgattgccaaggccttctctaagcggcacgagctcctg
cagaacccaggccaggagctgtccttcagcatgcacactgtgtcccacgacgggcccgtg
gcgggcttggcctttgacctcaatgagccctcagctgatgtctcctctgcctgggcccag
catgtcaccaagatggtggctcggagaggagccatactgccccaggatatttctgtcacc
cctgtggcaactccagtgcccccagaggaacaagccaacctgtggctggttgaggcagag
atctccccagagctgcagaagcgcctgggccggaagaagaagaggaggaagaggaagaag
gaggtgtgcccgctggcgccgccccctgagcttcacccccctgcccctgcccccagtacc
attcctcgactgcctcagctgccccggcagaaatgcctggtggctgcaggtgcctgggga
gctggggactcttgccgacagggagcgtggaccctggtctccaacccattctgcccagag
cccagtccccctcaggatccatttctgcccagtgcaccggcccccgtggcatgggctcat
ggccgccgacagggcctggggcctattcactcccgcaccaacctgatggacacagaactc
atggatgcagactcggacttctga

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (7)   
   KEGG DRUG (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
Protein domain (3)   
   Pfam (3)   
All databases (62)   

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