| Entry |
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| Gene name |
TYR, CMM8, OCA1A, OCAIA, SHEP3
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| Definition |
tyrosinase (EC:1.14.18.1)
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| Orthology |
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| Organism |
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| Pathway |
| Tyrosine metabolism | | Riboflavin metabolism | | Metabolic pathways | | Melanogenesis |
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| Module |
| Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline |
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| Disease |
| Oculocutaneous albinism (OCA) |
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| Drug target |
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| Class |
Metabolism; Amino acid metabolism; Tyrosine metabolism [PATH: hsa00350]
Metabolism; Metabolism of cofactors and vitamins; Riboflavin metabolism [PATH: hsa00740]
Organismal Systems; Endocrine system; Melanogenesis [PATH: hsa04916]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Position |
11q14-q21
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| AA seq |
529 aa  
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL |
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| NT seq |
1590 nt  +upstreamnt +downstreamnt
atgctcctggctgttttgtactgcctgctgtggagtttccagacctccgctggccatttc
cctagagcctgtgtctcctctaagaacctgatggagaaggaatgctgtccaccgtggagc
ggggacaggagtccctgtggccagctttcaggcagaggttcctgtcagaatatccttctg
tccaatgcaccacttgggcctcaatttcccttcacaggggtggatgaccgggagtcgtgg
ccttccgtcttttataataggacctgccagtgctctggcaacttcatgggattcaactgt
ggaaactgcaagtttggcttttggggaccaaactgcacagagagacgactcttggtgaga
agaaacatcttcgatttgagtgccccagagaaggacaaattttttgcctacctcacttta
gcaaagcataccatcagctcagactatgtcatccccatagggacctatggccaaatgaaa
aatggatcaacacccatgtttaacgacatcaatatttatgacctctttgtctggatgcat
tattatgtgtcaatggatgcactgcttgggggatctgaaatctggagagacattgatttt
gcccatgaagcaccagcttttctgccttggcatagactcttcttgttgcggtgggaacaa
gaaatccagaagctgacaggagatgaaaacttcactattccatattgggactggcgggat
gcagaaaagtgtgacatttgcacagatgagtacatgggaggtcagcaccccacaaatcct
aacttactcagcccagcatcattcttctcctcttggcagattgtctgtagccgattggag
gagtacaacagccatcagtctttatgcaatggaacgcccgagggacctttacggcgtaat
cctggaaaccatgacaaatccagaaccccaaggctcccctcttcagctgatgtagaattt
tgcctgagtttgacccaatatgaatctggttccatggataaagctgccaatttcagcttt
agaaatacactggaaggatttgctagtccacttactgggatagcggatgcctctcaaagc
agcatgcacaatgccttgcacatctatatgaatggaacaatgtcccaggtacagggatct
gccaacgatcctatcttccttcttcaccatgcatttgttgacagtatttttgagcagtgg
ctccgaaggcaccgtcctcttcaagaagtttatccagaagccaatgcacccattggacat
aaccgggaatcctacatggttccttttataccactgtacagaaatggtgatttctttatt
tcatccaaagatctgggctatgactatagctatctacaagattcagacccagactctttt
caagactacattaagtcctatttggaacaagcgagtcggatctggtcatggctccttggg
gcggcgatggtaggggccgtcctcactgccctgctggcagggcttgtgagcttgctgtgt
cgtcacaagagaaagcagcttcctgaagaaaagcagccactcctcatggagaaagaggat
taccacagcttgtatcagagccatttataa |
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