KEGG T01001: 7422

Homo sapiens (human): 7422

Entry

7422 CDS T01001

Gene name

VEGFA, MVCD1, VEGF, VPF

Definition

vascular endothelial growth factor A

Orthology

K05448

vascular endothelial growth factor A

Organism

hsa Homo sapiens (human)

Pathway

hsa04060	Cytokine-cytokine receptor interaction
hsa04066	HIF-1 signaling pathway
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04370	VEGF signaling pathway
hsa04510	Focal adhesion
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05219	Bladder cancer
hsa05323	Rheumatoid arthritis

Disease

H00018

Gastric cancer

Drug target

Bevacizumab:

Pegaptanib:

Ranibizumab:

Aflibercept:

Other:

Class

Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:hsa04370]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:hsa04066]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:hsa04150]
Environmental Information Processing; Signaling molecules and interaction; Cytokine-cytokine receptor interaction [PATH:hsa04060]
Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:hsa05205]
Human Diseases; Cancers; Pancreatic cancer [PATH:hsa05212]
Human Diseases; Cancers; Renal cell carcinoma [PATH:hsa05211]
Human Diseases; Cancers; Bladder cancer [PATH:hsa05219]
Human Diseases; Immune diseases; Rheumatoid arthritis [PATH:hsa05323]

SSDB

Motif

Pfam:

VEGF_C PDGF Ribosomal_60s

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1MKK 4GLN 4GLS 1FLT 3QTK 1VPP 2VPF 1MJV 1CZ8 1BJ1 3P9W 1MKG 1VPF 3S1K 3BDY 1TZH 1QTY 2FJG 1TZI 3S1B 2FJH 3V2A 2QR0 1KMX 1KAT 1VGH 2VGH

Position

6p12

AA seq 412 aa
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLG
CSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWT
GEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

NT seq 1239 nt +upstreamnt +downstreamnt
ctgacggacagacagacagacaccgcccccagccccagctaccacctcctccccggccgg
cggcggacagtggacgcggcggcgagccgcgggcaggggccggagcccgcgcccggaggc
ggggtggagggggtcggggctcgcggcgtcgcactgaaacttttcgtccaacttctgggc
tgttctcgcttcggaggagccgtggtccgcgcgggggaagccgagccgagcggagccgcg
agaagtgctagctcgggccgggaggagccgcagccggaggagggggaggaggaagaagag
aaggaagaggagagggggccgcagtggcgactcggcgctcggaagccgggctcatggacg
ggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcc
cgggcctcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccc
cacagcccgagccggagagggagcgcgagccgcgccggccccggtcgggcctccgaaacc
atgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccat
gccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtg
gtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggac
atcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctg
atgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtcc
aacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatg
agcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaa
aaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccggtat
aagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccctggagcctccctggc
ccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatccgcag
acgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagtta
aacgaacgtacttgcagatgtgacaagccgaggcggtga

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (26)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (19)   
   UniProt (1)   
   RefSeq(pep) (18)   
DNA sequence (94)   
   RefSeq(nuc) (18)   
   GenBank (38)   
   EMBL (38)   
3D Structure (27)   
   PDB (27)   
Protein domain (3)   
   Pfam (3)   
All databases (204)   

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