KEGG   Homo sapiens (human): 760Help
Entry
760               CDS       T01001                                 

Gene name
CA2, CA-II, CAC, CAII, Car2, HEL-76
Definition
carbonic anhydrase II (EC:4.2.1.1)
Orthology
K18245  
carbonic anhydrase 2 [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Disease
H00241  
Combined proximal and distal renal tubular acidosis (RTA type 3)
H00436  
Osteopetrosis
Drug target
Clofenamide: 
Acetazolamide: 
Diclofenamide: 
Dorzolamide: 
Brinzolamide: 
Methazolamide: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Energy metabolism
   00910 Nitrogen metabolism
    760 (CA2)
 Organismal Systems
  Digestive system
   04971 Gastric acid secretion
    760 (CA2)
   04972 Pancreatic secretion
    760 (CA2)
   04976 Bile secretion
    760 (CA2)
  Excretory system
   04964 Proximal tubule bicarbonate reclamation
    760 (CA2)
   04966 Collecting duct acid secretion
    760 (CA2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonate dehydratase
     760 (CA2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   760 (CA2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 
3KS3 3K34 3U7C 1LUG 4FU5 4FRC 4FPT 2FOU 4MTY 2NNO 3V7X 2NNS 4FVN 4FVO 3VBD 2ILI 1MOO 3SAX 3HS4 2WEG 3D92 3D93 2NNV 2FOS 4HF3 3MHO 2NXT 2FOV 2EU2 4ITO 3RYY 3M2Y 4FIK 3RYV 3RJ7 2NNG 3L14 3S71 2FOQ 3GZ0 3S9T 3S8X 3PYK 3ZP9 4HEZ 4MDG 4BF1 3MYQ 3M1K 3KNE 3RYZ 3M1W 3M14 3RYJ 3KIG 3SBI 3S74 3MWO 3M96 3M5S 3M04 2WEO 2QO8 3IBU 3HLJ 4KAP 4HEY 4E49 4E4A 3OKU 3OKV 3OIM 2WEJ 2QP6 2GD8 2AW1 4GGE 3V2M 3QYK 3PO6 3OYQ 3DD0 4DZ7 4DZ9 3P58 3P5A 2WD2 4JSA 4JSS 4BCW 4GL1 4E3F 4E3H 3V5G 3TVN 3S75 3RLD 3RG4 3P5L 3P3H 3OIK 3OIL 3N3J 3N0N 3MZC 3MNA 3MMF 3MHM 3M98 3KOK 3KON 3DCW 2AX2 1OQ5 1FR7 3RZ1 4MDL 3OYS 2CBA 4MDM 4JS6 4E3G 3U3A 3IBL 2HNC 2HL4 1ZFQ 3V3G 2VVA 1ZFK 4IWZ 4ILX 4IDR 4HT0 4E3D 3U47 3TVO 3S72 3S76 3RYX 3R16 3P3J 3OY0 3N4B 3M40 3DVC 3DVD 3DC9 3DCC 3DAZ 2QOA 2POU 2POV 2OSM 2OSF 2FMZ 2FMG 2EU3 1G0E 1G0F 1FR4 1CIL 4N0X 3V3J 1TH9 2X7S 3KOI 3T5Z 3SBH 3RZ5 3N2P 3MNH 3M2N 3IGP 3D9Z 2NWY 1ZGE 4M2W 2VVB 1Z9Y 2CBB 2CBD 3M3X 3M1Q 4ITP 4HEW 4E5Q 3V2J 3U45 3RZ8 3R17 3MHI 3MHC 3M5E 3M2Z 3HKQ 3DV7 3DVB 3DC3 3DBU 3D8W 3CYU 3C7P 2Q1B 2NXR 2NWO 1ZH9 1YO1 1MUA 1CAM 2F14 4M2V 3V3I 3T5U 3SAP 3S73 3MNI 3MNJ 3MNK 2POW 1ZGF 1LG5 4HBA 1XQ0 4KNI 3T83 3RZ0 3RZ7 3PJJ 3NB5 3MNU 3ML2 3M67 3M1J 3HKN 3HKU 2WD3 3DCS 3CAJ 2NXS 2NWP 2NWZ 2HD6 2FNK 2FNM 2FNN 1YO0 1YO2 1THK 1TG3 1I9Q 1G52 1ZSC 1CNI 1CNJ 1RZB 1RAY 1CAI 3FFP 1XEG 4BF6 2CBE 1G45 1I9M 1G4J 1G46 4MO8 4FL7 3V3H 3BET 1BV3 1H9N 3S77 1I9N 1I9O 1G54 1G48 1G3Z 3M2X 1CAH 2CBC 2X7T 3B4F 4JSW 4JSZ 3RG3 3MHL 3K7K 3F4X 3BL0 2HKK 2H15 1TG9 1LGD 1F2W 2H4N 1UGE 1CNX 1CNG 1YDB 1BCD 1RZA 1RZC 1RZD 1RZE 1RAZ 1CAZ 1CRA 1CAJ 1CAK 1BIC 1CAN 1CAO 2CA2 1I9P 3IBI 1IF4 1I9L 1I8Z 1IF8 1G53 3M5T 2Q38 1TTM 1YDC 1G4O 3S78 1IF7 4M2R 4M2U 4KNJ 4G0C 3V3F 3TMJ 3T82 3T84 3P4V 3P55 3NJ9 3KWA 3KKX 3IEO 3F8E 2GEH 2EZ7 2ABE 1ZE8 1TEQ 1TEU 1TE3 1TBT 1TB0 1T9N 1IF5 1IF9 1I90 1I91 1FSN 1FSQ 1FSR 1FQM 1FQN 1FQR 1FQL 1AVN 1AM6 1H4N 1UGA 1UGB 1UGC 1UGD 1UGF 1ZSB 1CNW 1HEA 1HEB 1HEC 1HED 3CA2 1CA2 1XPZ 1G1D 1CNH 1IF6 3RGE 3NI5 3HFP 2WEH 3BL1 2O4Z 2HOC 1EOU 1BN1 1BN4 1OKL 1YDA 1YDD 1CIM 1CIN 1DCB 1CAY 4CA2 5CA2 2X7U 4LP6 1BNT 1BNU 1CNK 3P44 3IBN 1XEV 1LG6 1BN3 1H9Q 1UGG 1OKM 1CCT 1CVD 1CNC 1DCA 1CAL 4CAC 5CAC 1KWR 1BNW 1A42 1CCU 1CVE 1CVF 1CVA 1LZV 1BNN 1CNY 1CVH 1CVC 1HVA 1HCA 1CA3 1CCS 1CNB 3HKT 3T85 1BNQ 1BNV 1OKN 1CVB 12CA 7CA2 8CA2 1ZSA 6CA2 1KWQ 1BNM 9CA2
Thumbnails

Jmol
Position
8q22
AA seq 260 aa AA seqDB search
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
NT seq 783 nt NT seq  +upstreamnt  +downstreamnt
atgtcccatcactgggggtacggcaaacacaacggacctgagcactggcataaggacttc
cccattgccaagggagagcgccagtcccctgttgacatcgacactcatacagccaagtat
gacccttccctgaagcccctgtctgtttcctatgatcaagcaacttccctgaggatcctc
aacaatggtcatgctttcaacgtggagtttgatgactctcaggacaaagcagtgctcaag
ggaggacccctggatggcacttacagattgattcagtttcactttcactggggttcactt
gatggacaaggttcagagcatactgtggataaaaagaaatatgctgcagaacttcacttg
gttcactggaacaccaaatatggggattttgggaaagctgtgcagcaacctgatggactg
gccgttctaggtatttttttgaaggttggcagcgctaaaccgggccttcagaaagttgtt
gatgtgctggattccattaaaacaaagggcaagagtgctgacttcactaacttcgatcct
cgtggcctccttcctgaatccttggattactggacctacccaggctcactgaccacccct
cctcttctggaatgtgtgacctggattgtgctcaaggaacccatcagcgtcagcagcgag
caggtgttgaaattccgtaaacttaacttcaatggggagggtgaacccgaagaactgatg
gtggacaactggcgcccagctcagccactgaagaacaggcaaatcaaagcttccttcaaa
taa

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