KEGG T01001: 7852

Homo sapiens (human): 7852

Entry

7852 CDS T01001

Gene name

CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM

Definition

chemokine (C-X-C motif) receptor 4

Orthology

K04189

C-X-C chemokine receptor type 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04144	Endocytosis
hsa04360	Axon guidance
hsa04670	Leukocyte transendothelial migration
hsa04672	Intestinal immune network for IgA production

Disease

H00097

Chemokine receptor defect

Drug target

Plerixafor:

D08971

Class

Environmental Information Processing; Signaling molecules and interaction; Cytokine-cytokine receptor interaction [PATH:hsa04060]
Cellular Processes; Transport and catabolism; Endocytosis [PATH:hsa04144]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:hsa04670]
Organismal Systems; Immune system; Intestinal immune network for IgA production [PATH:hsa04672]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:hsa04062]
Organismal Systems; Development; Axon guidance [PATH:hsa04360]

SSDB

Motif

Pfam:

7tm_1 CXCR4_N 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2K03 2K04 2K05

Position

2q21

AA seq 356 aa
MSIPLPLLQIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGN
GLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIY
TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFAN
VSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRK
ALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCC
LNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

NT seq 1071 nt +upstreamnt +downstreamnt
atgtccattcctttgcctcttttgcagatatacacttcagataactacaccgaggaaatg
ggctcaggggactatgactccatgaaggaaccctgtttccgtgaagaaaatgctaatttc
aataaaatcttcctgcccaccatctactccatcatcttcttaactggcattgtgggcaat
ggattggtcatcctggtcatgggttaccagaagaaactgagaagcatgacggacaagtac
aggctgcacctgtcagtggccgacctcctctttgtcatcacgcttcccttctgggcagtt
gatgccgtggcaaactggtactttgggaacttcctatgcaaggcagtccatgtcatctac
acagtcaacctctacagcagtgtcctcatcctggccttcatcagtctggaccgctacctg
gccatcgtccacgccaccaacagtcagaggccaaggaagctgttggctgaaaaggtggtc
tatgttggcgtctggatccctgccctcctgctgactattcccgacttcatctttgccaac
gtcagtgaggcagatgacagatatatctgtgaccgcttctaccccaatgacttgtgggtg
gttgtgttccagtttcagcacatcatggttggccttatcctgcctggtattgtcatcctg
tcctgctattgcattatcatctccaagctgtcacactccaagggccaccagaagcgcaag
gccctcaagaccacagtcatcctcatcctggctttcttcgcctgttggctgccttactac
attgggatcagcatcgactccttcatcctcctggaaatcatcaagcaagggtgtgagttt
gagaacactgtgcacaagtggatttccatcaccgaggccctagctttcttccactgttgt
ctgaaccccatcctctatgctttccttggagccaaatttaaaacctctgcccagcacgca
ctcacctctgtgagcagagggtccagcctcaagatcctctccaaaggaaagcgaggtgga
cattcatctgtttccactgagtctgagtcttcaagttttcactccagctaa

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (18)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
3D Structure (3)   
   PDB (3)   
Protein domain (4)   
   Pfam (4)   
All databases (91)   

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