KEGG   Homo sapiens (human): 805Help
Entry
805               CDS       T01001                                 

Gene name
CALM2, CAMII, LQT15, PHKD, PHKD2, caM
Definition
(RefSeq) calmodulin 2
  KO
K02183  calmodulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa05010  Alzheimer's disease
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05133  Pertussis
hsa05152  Tuberculosis
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05214  Glioma
hsa05418  Fluid shear stress and atherosclerosis
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00172  KSHV K15 to PLCG-calcineurin signaling pathway
N00180  KSHV K1 to PLCG-calcineurin signaling pathway
Disease
H00720  Long QT syndrome
Drug target
Lubeluzole: D04789
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    805 (CALM2)
   04015 Rap1 signaling pathway
    805 (CALM2)
   04371 Apelin signaling pathway
    805 (CALM2)
   04020 Calcium signaling pathway
    805 (CALM2)
   04070 Phosphatidylinositol signaling system
    805 (CALM2)
   04024 cAMP signaling pathway
    805 (CALM2)
   04022 cGMP - PKG signaling pathway
    805 (CALM2)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    805 (CALM2)
   04218 Cellular senescence
    805 (CALM2)
 Organismal Systems
  Immune system
   04625 C-type lectin receptor signaling pathway
    805 (CALM2)
  Endocrine system
   04910 Insulin signaling pathway
    805 (CALM2)
   04922 Glucagon signaling pathway
    805 (CALM2)
   04912 GnRH signaling pathway
    805 (CALM2)
   04915 Estrogen signaling pathway
    805 (CALM2)
   04921 Oxytocin signaling pathway
    805 (CALM2)
   04916 Melanogenesis
    805 (CALM2)
   04924 Renin secretion
    805 (CALM2)
   04925 Aldosterone synthesis and secretion
    805 (CALM2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    805 (CALM2)
   04270 Vascular smooth muscle contraction
    805 (CALM2)
  Digestive system
   04970 Salivary secretion
    805 (CALM2)
   04971 Gastric acid secretion
    805 (CALM2)
  Nervous system
   04728 Dopaminergic synapse
    805 (CALM2)
   04720 Long-term potentiation
    805 (CALM2)
   04722 Neurotrophin signaling pathway
    805 (CALM2)
  Sensory system
   04744 Phototransduction
    805 (CALM2)
   04740 Olfactory transduction
    805 (CALM2)
   04750 Inflammatory mediator regulation of TRP channels
    805 (CALM2)
  Environmental adaptation
   04713 Circadian entrainment
    805 (CALM2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    805 (CALM2)
   05214 Glioma
    805 (CALM2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    805 (CALM2)
  Substance dependence
   05031 Amphetamine addiction
    805 (CALM2)
   05034 Alcoholism
    805 (CALM2)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    805 (CALM2)
  Infectious diseases
   05133 Pertussis
    805 (CALM2)
   05152 Tuberculosis
    805 (CALM2)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    805 (CALM2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Regulatory subunits
     805 (CALM2)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    805 (CALM2)
Chromosome [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Centriole replication proteins
     805 (CALM2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   805 (CALM2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_8 EF-hand_6 EF-hand_5 EF-hand_9 EF-hand_4 SPARC_Ca_bdg EF-hand_11 UPF0154 EFhand_Ca_insen DUF1103 Caleosin DUF4497 TerB GPHH SurA_N_2 Poly_export DUF2267 SurA_N_3 Fe_hyd_lg_C MotA_activ
Motif
Other DBs
NCBI-GeneID: 805
NCBI-ProteinID: NP_001734
OMIM: 114182
HGNC: 1445
Ensembl: ENSG00000143933
Vega: OTTHUMG00000128850
UniProt: P0DP23 P0DP24 P0DP25 B4DJ51
Structure
PDB: 

Jmol
Position
2p21
AA seq 149 aa AA seqDB search
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
NT seq 450 nt NT seq  +upstreamnt  +downstreamnt
atggctgaccaactgactgaagagcagattgcagaattcaaagaagctttttcactattt
gacaaagatggtgatggaactataacaacaaaggaattgggaactgtaatgagatctctt
gggcagaatcccacagaagcagagttacaggacatgattaatgaagtagatgctgatggt
aatggcacaattgacttccctgaatttctgacaatgatggcaagaaaaatgaaagacaca
gacagtgaagaagaaattagagaagcattccgtgtgtttgataaggatggcaatggctat
attagtgctgcagaacttcgccatgtgatgacaaaccttggagagaagttaacagatgaa
gaagttgatgaaatgatcagggaagcagatattgatggtgatggtcaagtaaactatgaa
gagtttgtacaaatgatgacagcaaagtga

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