KEGG   Homo sapiens (human): 824Help
Entry
824               CDS       T01001                                 

Gene name
CAPN2, CANP2, CANPL2, CANPml, mCANP
Definition
calpain 2, (m/II) large subunit (EC:3.4.22.53)
Orthology
K03853  
calpain-2 [EC:3.4.22.53]
Organism
hsa  Homo sapiens (human)
Pathway
Protein processing in endoplasmic reticulum
Apoptosis
Focal adhesion
Alzheimer's disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    824 (CAPN2)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    824 (CAPN2)
  Cellular commiunity
   04510 Focal adhesion
    824 (CAPN2)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    824 (CAPN2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.53  calpain-2
     824 (CAPN2)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C2: calpain family
   824 (CAPN2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
1q41-q42
AA seq 622 aa AA seqDB search
MEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGI
FHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG
ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL
VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR
HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP
NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE
ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC
IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR
RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR
SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ
LDPENTGTIELDLISWLCFSVL
NT seq 1869 nt NT seq  +upstreamnt  +downstreamnt
atggagatctgcgctgacccccagtttatcattggaggagccacccgcacagacatctgc
caaggagccctgggtgactgctggctgctggcagccattgcctccctcaccttgaatgaa
gaaatcctggctcgagtcgtccccctaaaccagagcttccaggaaaactatgcagggatc
tttcacttccagttctggcaatacggcgagtgggtggaggtggtggtggatgacaggctg
cccaccaaggacggggagctgctctttgtgcattcagccgaagggagcgagttctggagc
gccctgctggagaaggcatacgccaagatcaacggatgctatgaagcgctatcagggggt
gccaccactgagggcttcgaagacttcaccggaggcattgctgagtggtatgagttgaag
aagccccctcccaacctgttcaagatcatccagaaagctctgcaaaaaggctctctcctt
ggctgctccatcgacatcaccagcgccgcggactcggaggccatcacgtttcagaagctg
gtgaaggggcacgcgtactcggtcaccggagccgaggaggttgaaagtaacggaagccta
cagaaactgatccgcatccgaaatccctggggagaagtggagtggacagggcggtggaat
gacaactgcccaagctggaacactatagacccagaggagagggaaaggctgaccagacgg
catgaagatggagaattctggatgtctttcagtgacttcctgaggcactattcccgcctg
gagatctgtaacctgaccccagacactctcaccagcgatacctacaagaagtggaaactc
accaaaatggatgggaactggaggcggggctccaccgcgggaggttgcaggaactacccg
aacacattctggatgaaccctcagtacctgatcaagctggaggaggaggatgaggacgag
gaggatggggagagcggctgcaccttcctggtggggctcattcagaagcaccgacggcgg
cagaggaagatgggcgaggacatgcacaccatcggctttggcatctatgaggttccagag
gagttaagtgggcagaccaacatccacctcagcaaaaacttcttcctgacgaatcgcgcc
agggagcgctcagacaccttcatcaacctccgggaggtgctcaaccgcttcaagctgccg
ccaggagagtacattctcgtgccttccaccttcgaacccaacaaggatggggatttctgc
atccgggtcttttctgaaaagaaagctgactaccaagctgtcgatgatgaaatcgaggcc
aatcttgaagagttcgacatcagcgaggatgacattgatgatggattcaggagactgttt
gcccagttggcaggagaggatgcggagatctctgcctttgagctgcagaccatcctgaga
agggttctagcaaagcgccaagatatcaagtcagatggcttcagcatcgagacatgcaaa
attatggttgacatgctagattcggacgggagtggcaagctggggctgaaggagttctac
attctctggacgaagattcaaaaataccaaaaaatttaccgagaaatcgacgttgacagg
tctggtaccatgaattcctatgaaatgcggaaggcattagaagaagcaggtttcaagatg
ccctgtcaactccaccaagtcatcgttgctcggtttgcagatgaccagctcatcatcgat
tttgataattttgttcggtgtttggttcggctggaaacgctattcaagatatttaagcag
ctggatcccgagaatactggaacaatagagctcgaccttatctcttggctctgtttctca
gtactttga

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