KEGG T01001: 824

Homo sapiens (human): 824

Entry

824 CDS T01001

Gene name

CAPN2, CANP2, CANPL2, CANPml, mCANP

Definition

calpain 2, (m/II) large subunit (EC:3.4.22.53)

Orthology

K03853

calpain-2 [EC:3.4.22.53]

Organism

hsa Homo sapiens (human)

Pathway

hsa04141	Protein processing in endoplasmic reticulum
hsa04210	Apoptosis
hsa04510	Focal adhesion
hsa05010	Alzheimer's disease

Class

Genetic Information Processing; Folding, sorting and degradation; Protein processing in endoplasmic reticulum [PATH:hsa04141]
Cellular Processes; Cell growth and death; Apoptosis [PATH:hsa04210]
Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:hsa05010]

SSDB

Motif

Pfam:

Peptidase_C2 Calpain_III EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_7

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1KFU 1KFX

Position

1q41-q42

AA seq 622 aa
MEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGI
FHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG
ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL
VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR
HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP
NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE
ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC
IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR
RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR
SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ
LDPENTGTIELDLISWLCFSVL

NT seq 1869 nt +upstreamnt +downstreamnt
atggagatctgcgctgacccccagtttatcattggaggagccacccgcacagacatctgc
caaggagccctgggtgactgctggctgctggcagccattgcctccctcaccttgaatgaa
gaaatcctggctcgagtcgtccccctaaaccagagcttccaggaaaactatgcagggatc
tttcacttccagttctggcaatacggcgagtgggtggaggtggtggtggatgacaggctg
cccaccaaggacggggagctgctctttgtgcattcagccgaagggagcgagttctggagc
gccctgctggagaaggcatacgccaagatcaacggatgctatgaagcgctatcagggggt
gccaccactgagggcttcgaagacttcaccggaggcattgctgagtggtatgagttgaag
aagccccctcccaacctgttcaagatcatccagaaagctctgcaaaaaggctctctcctt
ggctgctccatcgacatcaccagcgccgcggactcggaggccatcacgtttcagaagctg
gtgaaggggcacgcgtactcggtcaccggagccgaggaggttgaaagtaacggaagccta
cagaaactgatccgcatccgaaatccctggggagaagtggagtggacagggcggtggaat
gacaactgcccaagctggaacactatagacccagaggagagggaaaggctgaccagacgg
catgaagatggagaattctggatgtctttcagtgacttcctgaggcactattcccgcctg
gagatctgtaacctgaccccagacactctcaccagcgatacctacaagaagtggaaactc
accaaaatggatgggaactggaggcggggctccaccgcgggaggttgcaggaactacccg
aacacattctggatgaaccctcagtacctgatcaagctggaggaggaggatgaggacgag
gaggatggggagagcggctgcaccttcctggtggggctcattcagaagcaccgacggcgg
cagaggaagatgggcgaggacatgcacaccatcggctttggcatctatgaggttccagag
gagttaagtgggcagaccaacatccacctcagcaaaaacttcttcctgacgaatcgcgcc
agggagcgctcagacaccttcatcaacctccgggaggtgctcaaccgcttcaagctgccg
ccaggagagtacattctcgtgccttccaccttcgaacccaacaaggatggggatttctgc
atccgggtcttttctgaaaagaaagctgactaccaagctgtcgatgatgaaatcgaggcc
aatcttgaagagttcgacatcagcgaggatgacattgatgatggattcaggagactgttt
gcccagttggcaggagaggatgcggagatctctgcctttgagctgcagaccatcctgaga
agggttctagcaaagcgccaagatatcaagtcagatggcttcagcatcgagacatgcaaa
attatggttgacatgctagattcggacgggagtggcaagctggggctgaaggagttctac
attctctggacgaagattcaaaaataccaaaaaatttaccgagaaatcgacgttgacagg
tctggtaccatgaattcctatgaaatgcggaaggcattagaagaagcaggtttcaagatg
ccctgtcaactccaccaagtcatcgttgctcggtttgcagatgaccagctcatcatcgat
tttgataattttgttcggtgtttggttcggctggaaacgctattcaagatatttaagcag
ctggatcccgagaatactggaacaatagagctcgaccttatctcttggctctgtttctca
gtactttga

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (16)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (3)   
   RefSeq(pep) (2)   
DNA sequence (40)   
   RefSeq(nuc) (2)   
   GenBank (19)   
   EMBL (19)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (84)   

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