KEGG   Homo sapiens (human): 841Help
Entry
841               CDS       T01001                                 

Gene name
CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Definition
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)
Orthology
K04398  
caspase 8 [EC:3.4.22.61]
Organism
hsa  Homo sapiens (human)
Pathway
p53 signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Huntington's disease
Legionellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Viral myocarditis
Disease
H00108  
Autoimmune lymphoproliferative syndromes (ALPS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    841 (CASP8)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    841 (CASP8)
   04115 p53 signaling pathway
    841 (CASP8)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    841 (CASP8)
   04621 NOD-like receptor signaling pathway
    841 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    841 (CASP8)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    841 (CASP8)
   05203 Viral carcinogenesis
    841 (CASP8)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    841 (CASP8)
   05016 Huntington's disease
    841 (CASP8)
  Cardiovascular diseases
   05416 Viral myocarditis
    841 (CASP8)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    841 (CASP8)
  Infectious diseases
   05134 Legionellosis
    841 (CASP8)
   05152 Tuberculosis
    841 (CASP8)
   05161 Hepatitis B
    841 (CASP8)
   05168 Herpes simplex infection
    841 (CASP8)
   05145 Toxoplasmosis
    841 (CASP8)
   05142 Chagas disease (American trypanosomiasis)
    841 (CASP8)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     841 (CASP8)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C14: caspase family
   841 (CASP8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
2q33-q34
AA seq 464 aa AA seqDB search
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLH
SIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS
EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR
GDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
NT seq 1395 nt NT seq  +upstreamnt  +downstreamnt
atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc
tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc
ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac
actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc
tacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtctttt
aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg
gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg
aaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaa
ttcagcaaaggggaggagttgtgtggggtaatgacaatctcggactctccaagagaacag
gatagtgaatcacagactttggacaaagtttaccaaatgaaaagcaaacctcggggatac
tgtctgatcatcaacaatcacaattttgcaaaagcacgggagaaagtgcccaaacttcac
agcattagggacaggaatggaacacacttggatgcaggggctttgaccacgacctttgaa
gagcttcattttgagatcaagccccacgatgactgcacagtagagcaaatctatgagatt
ttgaaaatctaccaactcatggaccacagtaacatggactgcttcatctgctgtatcctc
tcccatggagacaagggcatcatctatggcactgatggacaggaggcccccatctatgag
ctgacatctcagttcactggtttgaagtgcccttcccttgctggaaaacccaaagtgttt
tttattcaggcttgtcagggggataactaccagaaaggtatacctgttgagactgattca
gaggagcaaccctatttagaaatggatttatcatcacctcaaacgagatatatcccggat
gaggctgactttctgctggggatggccactgtgaataactgtgtttcctaccgaaaccct
gcagagggaacctggtacatccagtcactttgccagagcctgagagagcgatgtcctcga
ggcgatgatattctcaccatcctgactgaagtgaactatgaagtaagcaacaaggatgac
aagaaaaacatggggaaacagatgcctcagcctactttcacactaagaaaaaaacttgtc
ttcccttctgattga

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