KEGG   Homo sapiens (human): 842Help
Entry
842               CDS       T01001                                 

Gene name
CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Definition
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)
Orthology
K04399  
caspase 9 [EC:3.4.22.62]
Organism
hsa  Homo sapiens (human)
Pathway
p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
VEGF signaling pathway
Thyroid hormone signaling pathway
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Legionellosis
Toxoplasmosis
Tuberculosis
Hepatitis B
Influenza A
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Small cell lung cancer
Non-small cell lung cancer
Viral myocarditis
Module
Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    842 (CASP9)
   04151 PI3K-Akt signaling pathway
    842 (CASP9)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    842 (CASP9)
   04115 p53 signaling pathway
    842 (CASP9)
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    842 (CASP9)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    842 (CASP9)
   05210 Colorectal cancer
    842 (CASP9)
   05212 Pancreatic cancer
    842 (CASP9)
   05215 Prostate cancer
    842 (CASP9)
   05213 Endometrial cancer
    842 (CASP9)
   05222 Small cell lung cancer
    842 (CASP9)
   05223 Non-small cell lung cancer
    842 (CASP9)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    842 (CASP9)
   05012 Parkinson's disease
    842 (CASP9)
   05014 Amyotrophic lateral sclerosis (ALS)
    842 (CASP9)
   05016 Huntington's disease
    842 (CASP9)
  Cardiovascular diseases
   05416 Viral myocarditis
    842 (CASP9)
  Infectious diseases
   05134 Legionellosis
    842 (CASP9)
   05152 Tuberculosis
    842 (CASP9)
   05164 Influenza A
    842 (CASP9)
   05161 Hepatitis B
    842 (CASP9)
   05145 Toxoplasmosis
    842 (CASP9)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.62  caspase-9
     842 (CASP9)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     842 (CASP9)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C14: caspase family
   842 (CASP9)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
1p36.21
AA seq 416 aa AA seqDB search
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
NT seq 1251 nt NT seq  +upstreamnt  +downstreamnt
atggacgaagcggatcggcggctcctgcggcggtgccggctgcggctggtggaagagctg
caggtggaccagctctgggacgccctgctgagccgcgagctgttcaggccccatatgatc
gaggacatccagcgggcaggctctggatctcggcgggatcaggccaggcagctgatcata
gatctggagactcgagggagtcaggctcttcctttgttcatctcctgcttagaggacaca
ggccaggacatgctggcttcgtttctgcgaactaacaggcaagcagcaaagttgtcgaag
ccaaccctagaaaaccttaccccagtggtgctcagaccagagattcgcaaaccagaggtt
ctcagaccggaaacacccagaccagtggacattggttctggaggatttggtgatgtcggt
gctcttgagagtttgaggggaaatgcagatttggcttacatcctgagcatggagccctgt
ggccactgcctcattatcaacaatgtgaacttctgccgtgagtccgggctccgcacccgc
actggctccaacatcgactgtgagaagttgcggcgtcgcttctcctcgctgcatttcatg
gtggaggtgaagggcgacctgactgccaagaaaatggtgctggctttgctggagctggcg
cagcaggaccacggtgctctggactgctgcgtggtggtcattctctctcacggctgtcag
gccagccacctgcagttcccaggggctgtctacggcacagatggatgccctgtgtcggtc
gagaagattgtgaacatcttcaatgggaccagctgccccagcctgggagggaagcccaag
ctctttttcatccaggcctgtggtggggagcagaaagaccatgggtttgaggtggcctcc
acttcccctgaagacgagtcccctggcagtaaccccgagccagatgccaccccgttccag
gaaggtttgaggaccttcgaccagctggacgccatatctagtttgcccacacccagtgac
atctttgtgtcctactctactttcccaggttttgtttcctggagggaccccaagagtggc
tcctggtacgttgagaccctggacgacatctttgagcagtgggctcactctgaagacctg
cagtccctcctgcttagggtcgctaatgctgtttcggtgaaagggatttataaacagatg
cctggttgctttaatttcctccggaaaaaacttttctttaaaacatcataa

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