KEGG   Homo sapiens (human): 8517Help
Entry
8517              CDS       T01001                                 

Gene name
IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Definition
(RefSeq) inhibitor of nuclear factor kappa B kinase subunit gamma
  KO
K07210  inhibitor of nuclear factor kappa-B kinase subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05131  Shigellosis
hsa05142  Chagas disease (American trypanosomiasis)
hsa05145  Toxoplasmosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05165  Human papillomavirus infection
hsa05166  HTLV-I infection
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05212  Pancreatic cancer
hsa05215  Prostate cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05340  Primary immunodeficiency
hsa05418  Fluid shear stress and atherosclerosis
Module
hsa_M00686  Toll-like receptor signaling
Network
N00151  TNF-NFKB signaling pathway
N00171  KSHV vFLIP to NFKB signaling pathway
N00173  KSHV K15 to NFKB signaling pathway
N00174  KSHV vFLIP to TNF-NFKB signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00201  KSHV vFLIP to host-cell-protein activation
N00221  HTLV-I Tax to host-cell-protein activation
Disease
H00095  Ectodermal dysplasia associated immunodeficiency (EDA-ID)
H00540  Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)
H00645  Incontinentia pigmenti
H01245  Immunodeficiency without anhidrotic ectodermal dysplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    8517 (IKBKG)
   04010 MAPK signaling pathway
    8517 (IKBKG)
   04064 NF-kappa B signaling pathway
    8517 (IKBKG)
   04668 TNF signaling pathway
    8517 (IKBKG)
   04151 PI3K-Akt signaling pathway
    8517 (IKBKG)
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    8517 (IKBKG)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    8517 (IKBKG)
   04621 NOD-like receptor signaling pathway
    8517 (IKBKG)
   04622 RIG-I-like receptor signaling pathway
    8517 (IKBKG)
   04623 Cytosolic DNA-sensing pathway
    8517 (IKBKG)
   04625 C-type lectin receptor signaling pathway
    8517 (IKBKG)
   04660 T cell receptor signaling pathway
    8517 (IKBKG)
   04658 Th1 and Th2 cell differentiation
    8517 (IKBKG)
   04659 Th17 cell differentiation
    8517 (IKBKG)
   04657 IL-17 signaling pathway
    8517 (IKBKG)
   04662 B cell receptor signaling pathway
    8517 (IKBKG)
   04062 Chemokine signaling pathway
    8517 (IKBKG)
  Endocrine system
   04920 Adipocytokine signaling pathway
    8517 (IKBKG)
  Development
   04380 Osteoclast differentiation
    8517 (IKBKG)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    8517 (IKBKG)
   05203 Viral carcinogenesis
    8517 (IKBKG)
   05212 Pancreatic cancer
    8517 (IKBKG)
   05221 Acute myeloid leukemia
    8517 (IKBKG)
   05220 Chronic myeloid leukemia
    8517 (IKBKG)
   05215 Prostate cancer
    8517 (IKBKG)
   05222 Small cell lung cancer
    8517 (IKBKG)
  Immune diseases
   05340 Primary immunodeficiency
    8517 (IKBKG)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    8517 (IKBKG)
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    8517 (IKBKG)
   05131 Shigellosis
    8517 (IKBKG)
   05166 HTLV-I infection
    8517 (IKBKG)
   05161 Hepatitis B
    8517 (IKBKG)
   05160 Hepatitis C
    8517 (IKBKG)
   05168 Herpes simplex infection
    8517 (IKBKG)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    8517 (IKBKG)
   05169 Epstein-Barr virus infection
    8517 (IKBKG)
   05165 Human papillomavirus infection
    8517 (IKBKG)
   05145 Toxoplasmosis
    8517 (IKBKG)
   05142 Chagas disease (American trypanosomiasis)
    8517 (IKBKG)
  Drug resistance
   01523 Antifolate resistance
    8517 (IKBKG)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   8517 (IKBKG)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: CC2-LZ NEMO Bacillus_HBL LLC1
Motif
Other DBs
NCBI-GeneID: 8517
NCBI-ProteinID: NP_001093327
OMIM: 300248
HGNC: 5961
Ensembl: ENSG00000269335
Vega: OTTHUMG00000024234
Pharos: Q9Y6K9(Tbio)
UniProt: Q9Y6K9
Structure
PDB: 

Jmol
Position
Xq28
AA seq 419 aa AA seqDB search
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
NT seq 1260 nt NT seq  +upstreamnt  +downstreamnt
atgaataggcacctctggaagagccaactgtgtgagatggtgcagcccagtggtggcccg
gcagcagatcaggacgtactgggcgaagagtctcctctggggaagccagccatgctgcac
ctgccttcagaacagggcgctcctgagaccctccagcgctgcctggaggagaatcaagag
ctccgagatgccatccggcagagcaaccagattctgcgggagcgctgcgaggagcttctg
catttccaagccagccagagggaggagaaggagttcctcatgtgcaagttccaggaggcc
aggaaactggtggagagactcggcctggagaagctcgatctgaagaggcagaaggagcag
gctctgcgggaggtggagcacctgaagagatgccagcagcagatggctgaggacaaggcc
tctgtgaaagcccaggtgacgtccttgctcggggagctgcaggagagccagagtcgcttg
gaggctgccactaaggaatgccaggctctggagggtcgggcccgggcggccagcgagcag
gcgcggcagctggagagtgagcgcgaggcgctgcagcagcagcacagcgtgcaggtggac
cagctgcgcatgcagggccagagcgtggaggccgcgctccgcatggagcgccaggccgcc
tcggaggagaagaggaagctggcccagttgcaggtggcctatcaccagctcttccaagaa
tacgacaaccacatcaagagcagcgtggtgggcagtgagcggaagcgaggaatgcagctg
gaagatctcaaacagcagctccagcaggccgaggaggccctggtggccaaacaggaggtg
atcgataagctgaaggaggaggccgagcagcacaagattgtgatggagaccgttccggtg
ctgaaggcccaggcggatatctacaaggcggacttccaggctgagaggcaggcccgggag
aagctggccgagaagaaggagctcctgcaggagcagctggagcagctgcagagggagtac
agcaaactgaaggccagctgtcaggagtcggccaggatcgaggacatgaggaagcggcat
gtcgaggtctcccaggcccccttgccccccgcccctgcctacctctcctctcccctggcc
ctgcccagccagaggaggagcccccccgaggagccacctgacttctgctgtcccaagtgc
cagtatcaggcccctgatatggacaccctgcagatacatgtcatggagtgcattgagtag

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