KEGG T01001: 8945

Homo sapiens (human): 8945

Entry

8945 CDS T01001

Gene name

BTRC, BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP

Definition

beta-transducin repeat containing E3 ubiquitin protein ligase

Orthology

K03362

F-box and WD-40 domain protein 1/11

Organism

hsa Homo sapiens (human)

Pathway

hsa04114	Oocyte meiosis
hsa04120	Ubiquitin mediated proteolysis
hsa04310	Wnt signaling pathway
hsa04340	Hedgehog signaling pathway
hsa04390	Hippo signaling pathway
hsa04710	Circadian rhythm
hsa05131	Shigellosis

Module

hsa_M00380

SCF-BTRC complex

Class

Genetic Information Processing; Folding, sorting and degradation; Ubiquitin mediated proteolysis [PATH:hsa04120]
Environmental Information Processing; Signal transduction; Wnt signaling pathway [PATH:hsa04310]
Environmental Information Processing; Signal transduction; Hedgehog signaling pathway [PATH:hsa04340]
Environmental Information Processing; Signal transduction; Hippo signaling pathway [PATH:hsa04390]
Cellular Processes; Cell growth and death; Oocyte meiosis [PATH:hsa04114]
Organismal Systems; Environmental adaptation; Circadian rhythm [PATH:hsa04710]
Human Diseases; Infectious diseases; Shigellosis [PATH:hsa05131]

SSDB

Motif

Pfam:

WD40 Beta-TrCP_D F-box-like F-box Nucleoporin_N Nup160 DUF4508

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Q9Y297 B2R8L3 B7Z3H4 Q68DS0

Structure

PDB:

2P64 1P22

Position

10q24.32

AA seq 579 aa
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQTYNSCARL
CLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSE
SDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLC
AAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNS
FYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIK
IWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV
LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR
TIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE
ELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF
QIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR

NT seq 1740 nt +upstreamnt +downstreamnt
atggacccggccgaggcggtgctgcaagagaaggcactcaagtttatgtgctctatgccc
aggtctctgtggctgggctgctccagcctggcggacagcatgccttcgctgcgatgcctg
tataacccagggactggcgcactcacagctttccagacatacaacagctgtgccagactc
tgcttaaaccaagaaacagtatgtttagcaagcactgctatgaagactgagaattgtgtg
gccaaaacaaaacttgccaatggcacttccagtatgattgtgcccaagcaacggaaactc
tcagcaagctatgaaaaggaaaaggaactgtgtgtcaaatactttgagcagtggtcagag
tcagatcaagtggaatttgtggaacatcttatatcccaaatgtgtcattaccaacatggg
cacataaactcgtatcttaaacctatgttgcagagagatttcataactgctctgccagct
cggggattggatcatattgctgagaacattctgtcatacctggatgccaaatcactatgt
gctgctgaacttgtgtgcaaggaatggtaccgagtgacctctgatggcatgctgtggaag
aagcttatcgagagaatggtcaggacagattctctgtggagaggcctggcagaacgaaga
ggatggggacagtatttattcaaaaacaaacctcctgacgggaatgctcctcccaactct
ttttatagagcactttatcctaaaattatacaagacattgagacaatagaatctaattgg
agatgtggaagacatagtttacagagaattcactgccgaagtgaaacaagcaaaggagtt
tactgtttacagtatgatgatcagaaaatagtaagcggccttcgagacaacacaatcaag
atctgggataaaaacacattggaatgcaagcgaattctcacaggccatacaggttcagtc
ctctgtctccagtatgatgagagagtgatcataacaggatcatcggattccacggtcaga
gtgtgggatgtaaatacaggtgaaatgctaaacacgttgattcaccattgtgaagcagtt
ctgcacttgcgtttcaataatggcatgatggtgacctgctccaaagatcgttccattgct
gtatgggatatggcctccccaactgacattaccctccggagggtgctggtcggacaccga
gctgctgtcaatgttgtagactttgatgacaagtacattgtttctgcatctggggataga
actataaaggtatggaacacaagtacttgtgaatttgtaaggaccttaaatggacacaaa
cgaggcattgcctgtttgcagtacagggacaggctggtagtgagtggctcatctgacaac
actatcagattatgggacatagaatgtggtgcatgtttacgagtgttagaaggccatgag
gaattggtgcgttgtattcgatttgataacaagaggatagtcagtggggcctatgatgga
aaaattaaagtgtgggatcttgtggctgctttggacccccgtgctcctgcagggacactc
tgtctacggacccttgtggagcattccggaagagtttttcgactacagtttgatgaattc
cagattgtcagtagttcacatgatgacacaatcctcatctgggacttcctaaatgatcca
gctgcccaagctgaacccccccgttccccttctcgaacatacacctacatctccagataa

All links

Pathway (8)   
   KEGG PATHWAY (7)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (14)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (4)   
   RefSeq(pep) (3)   
DNA sequence (45)   
   RefSeq(nuc) (3)   
   GenBank (21)   
   EMBL (21)   
3D Structure (2)   
   PDB (2)   
Protein domain (7)   
   Pfam (7)   
All databases (93)   

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