KEGG   Homo sapiens (human): 925
Entry
925               CDS       T01001                                 
Symbol
CD8A, CD8, CD8alpha, IMD116, Leu2, p32
Name
(RefSeq) CD8 subunit alpha
  KO
K06458  T-cell surface glycoprotein CD8 alpha chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Lifileucel: D12833<US>
Tucidinostat: D10993<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    925 (CD8A)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    925 (CD8A)
   04612 Antigen processing and presentation
    925 (CD8A)
   04660 T cell receptor signaling pathway
    925 (CD8A)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    925 (CD8A)
  09163 Immune disease
   05340 Primary immunodeficiency
    925 (CD8A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    925 (CD8A)
CD molecules [BR:hsa04090]
 Proteins
  925 (CD8A)
SSDB
Motif
Pfam: V-set Ig_3 I-set ig Ig_2
Other DBs
NCBI-GeneID: 925
NCBI-ProteinID: NP_001139345
OMIM: 186910
HGNC: 1706
Ensembl: ENSG00000153563
UniProt: P01732 Q6ZVS2 Q8TAW8
Structure
Position
2:complement(86784605..86808396)
AA seq 235 aa
MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQP
RGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSN
SIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFA
CDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV
NT seq 708 nt   +upstreamnt  +downstreamnt
atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccagg
ccgagccagttccgggtgtcgccgctggatcggacctggaacctgggcgagacagtggag
ctgaagtgccaggtgctgctgtccaacccgacgtcgggctgctcgtggctcttccagccg
cgcggcgccgccgccagtcccaccttcctcctatacctctcccaaaacaagcccaaggcg
gccgaggggctggacacccagcggttctcgggcaagaggttgggggacaccttcgtcctc
accctgagcgacttccgccgagagaacgagggctactatttctgctcggccctgagcaac
tccatcatgtacttcagccacttcgtgccggtcttcctgccagcgaagcccaccacgacg
ccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgc
ccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcc
tgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactg
gttatcaccctttactgcaaccacaggaaccgaagacgtgtttgcaaatgtccccggcct
gtggtcaaatcgggagacaagcccagcctttcggcgagatacgtctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (29)   
   RefSeq(nuc) (9)   
   GenBank (10)   
   EMBL (10)   
3D Structure (8)   
   PDB (8)   
Protein domain (5)   
   Pfam (5)   
All databases (82)   

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