KEGG   Homo sapiens (human): 933
Entry
933               CDS       T01001                                 
Symbol
CD22, SIGLEC-2, SIGLEC2
Name
(RefSeq) CD22 molecule
  KO
K06467  CD22 antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04640  Hematopoietic cell lineage
hsa04662  B cell receptor signaling pathway
Drug target
Bectumomab: D03066
Epratuzumab: D04036
Inotuzumab ozogamicin: D08933<JP/US>
Moxetumomab pasudotox: D09932<US>
Yttrium Y 90 epratuzumab: D06348
Yttrium Y 90 epratuzumab tetraxetan: D06349
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    933 (CD22)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    933 (CD22)
   04662 B cell receptor signaling pathway
    933 (CD22)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    933 (CD22)
   04091 Lectins [BR:hsa04091]
    933 (CD22)
CD molecules [BR:hsa04090]
 Proteins
  933 (CD22)
Lectins [BR:hsa04091]
 I-type lectins (Siglecs)
  933 (CD22)
SSDB
Motif
Pfam: Ig_3 Ig_2 ig I-set V-set Ig_4 C2-set_2 Ig_5 C1-set ICAM_N Izumo-Ig
Other DBs
NCBI-GeneID: 933
NCBI-ProteinID: NP_001762
OMIM: 107266
HGNC: 1643
Ensembl: ENSG00000012124
UniProt: P20273 Q0EAF5
Structure
Position
19:35329187..35347361
AA seq 847 aa
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH
NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR
MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG
VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH
TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT
KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL
PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT
TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ
FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM
SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ
GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG
LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES
SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV
DYVILKH
NT seq 2544 nt   +upstreamnt  +downstreamnt
atgcatctcctcggcccctggctcctgctcctggttctagaatacttggctttctctgac
tcaagtaaatgggtttttgagcaccctgaaaccctctacgcctgggagggggcctgcgtc
tggatcccctgcacctacagagccctagatggtgacctggaaagcttcatcctgttccac
aatcctgagtataacaagaacacctcgaagtttgatgggacaagactctatgaaagcaca
aaggatgggaaggttccttctgagcagaaaagggtgcaattcctgggagacaagaataag
aactgcacactgagtatccacccggtgcacctcaatgacagtggtcagctggggctgagg
atggagtccaagactgagaaatggatggaacgaatacacctcaatgtctctgaaaggcct
tttccacctcatatccagctccctccagaaattcaagagtcccaggaagtcactctgacc
tgcttgctgaatttctcctgctatgggtatccgatccaattgcagtggctcctagagggg
gttccaatgaggcaggctgctgtcacctcgacctccttgaccatcaagtctgtcttcacc
cggagcgagctcaagttctccccacagtggagtcaccatgggaagattgtgacctgccag
cttcaggatgcagatgggaagttcctctccaatgacacggtgcagctgaacgtgaagcac
accccgaagttggagatcaaggtcactcccagtgatgccatagtgagggagggggactct
gtgaccatgacctgcgaggtcagcagcagcaacccggagtacacgacggtatcctggctc
aaggatgggacctcgctgaagaagcagaatacattcacgctaaacctgcgcgaagtgacc
aaggaccagagtgggaagtactgctgtcaggtctccaatgacgtgggcccgggaaggtcg
gaagaagtgttcctgcaagtgcagtatgccccggaaccttccacggttcagatcctccac
tcaccggctgtggagggaagtcaagtcgagtttctttgcatgtcactggccaatcctctt
ccaacaaattacacgtggtaccacaatgggaaagaaatgcagggaaggacagaggagaaa
gtccacatcccaaagatcctcccctggcacgctgggacttattcctgtgtggcagaaaac
attcttggtactggacagaggggcccgggagctgagctggatgtccagtatcctcccaag
aaggtgaccacagtgattcaaaaccccatgccgattcgagaaggagacacagtgaccctt
tcctgtaactacaattccagtaaccccagtgttacccggtatgaatggaaaccccatggc
gcctgggaggagccatcgcttggggtgctgaagatccaaaacgttggctgggacaacaca
accatcgcctgcgcagcttgtaatagttggtgctcgtgggcctcccctgtcgccctgaat
gtccagtatgccccccgagacgtgagggtccggaaaatcaagcccctttccgagattcac
tctggaaactcggtcagcctccaatgtgacttctcaagcagccaccccaaagaagtccag
ttcttctgggagaaaaatggcaggcttctggggaaagaaagccagctgaattttgactcc
atctccccagaagatgctgggagttacagctgctgggtgaacaactccataggacagaca
gcgtccaaggcctggacacttgaagtgctgtatgcacccaggaggctgcgtgtgtccatg
agcccgggggaccaagtgatggaggggaagagtgcaaccctgacctgtgagagcgacgcc
aaccctcccgtctcccactacacctggtttgactggaataaccaaagcctcccctaccac
agccagaagctgagattggagccggtgaaggtccagcactcgggtgcctactggtgccag
gggaccaacagtgtgggcaagggccgttcgcctctcagcaccctcaccgtctactatagc
ccggagaccatcggcaggcgagtggctgtgggactcgggtcctgcctcgccatcctcatc
ctggcaatctgtgggctcaagctccagcgacgttggaagaggacacagagccagcagggg
cttcaggagaattccagcggccagagcttctttgtgaggaataaaaaggttagaagggcc
cccctctctgaaggcccccactccctgggatgctacaatccaatgatggaagatggcatt
agctacaccaccctgcgctttcccgagatgaacataccacgaactggagatgcagagtcc
tcagagatgcagagacctcccccggactgcgatgacacggtcacttattcagcattgcac
aagcgccaagtgggcgactatgagaacgtcattccagattttccagaagatgaggggatt
cattactcagagctgatccagtttggggtcggggagcggcctcaggcacaagaaaatgtg
gactatgtgatcctcaaacattga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (56)   
   KEGG ORTHOLOGY (1)   
   RefGene (47)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (32)   
   RefSeq(nuc) (6)   
   GenBank (13)   
   EMBL (13)   
3D Structure (4)   
   PDB (4)   
Protein domain (11)   
   Pfam (11)   
All databases (125)   

Download RDF
DBGET integrated database retrieval system