KEGG   Homo sapiens (human): 959Help
Entry
959               CDS       T01001                                 

Gene name
CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
Definition
(RefSeq) CD40 ligand
  KO
K03161  tumor necrosis factor ligand superfamily member 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05322  Systemic lupus erythematosus
hsa05330  Allograft rejection
hsa05340  Primary immunodeficiency
hsa05416  Viral myocarditis
Disease
H00093  Combined immunodeficiencies (CIDs)
Drug target
Ruplizumab: D05777
Toralizumab: D06193
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    959 (CD40LG)
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    959 (CD40LG)
   04514 Cell adhesion molecules (CAMs)
    959 (CD40LG)
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    959 (CD40LG)
   04672 Intestinal immune network for IgA production
    959 (CD40LG)
 Human Diseases
  Immune diseases
   05310 Asthma
    959 (CD40LG)
   05322 Systemic lupus erythematosus
    959 (CD40LG)
   05320 Autoimmune thyroid disease
    959 (CD40LG)
   05330 Allograft rejection
    959 (CD40LG)
   05340 Primary immunodeficiency
    959 (CD40LG)
  Cardiovascular diseases
   05416 Viral myocarditis
    959 (CD40LG)
  Infectious diseases
   05144 Malaria
    959 (CD40LG)
   05145 Toxoplasmosis
    959 (CD40LG)
Cytokines [BR:hsa04052]
 TNF family
  959 (CD40LG)
Cell adhesion molecules and their ligands [BR:hsa04516]
 2. Integrin Family
  Beta1 integrins
   VLA-5
    ITGB1; integrin beta 1 [KO:K05719]
     959 (CD40LG)
  Beta2 integrins
   CR3, Mac-1
    ITGB2; integrin beta 2 [KO:K06464]
     959 (CD40LG)
  Beta3 integrins
   alpha IIb  beta 3
    ITGB3; integrin beta 3 [KO:K06493]
     959 (CD40LG)
 7. Others
  TNFRSF5, CD40; tumor necrosis factor receptor superfamily, member 5 [KO:K03160]
   959 (CD40LG)
CD molecules [BR:hsa04090]
 Proteins
  959 (CD40LG)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: TNF
Motif
Other DBs
NCBI-GeneID: 959
NCBI-ProteinID: NP_000065
OMIM: 300386
HGNC: 11935
Ensembl: ENSG00000102245
Vega: OTTHUMG00000022512
Pharos: P29965(Tbio)
UniProt: P29965
Structure
PDB: 

Jmol
Position
Xq26.3
AA seq 261 aa AA seqDB search
MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLH
EDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNP
QIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSN
REASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVN
VTDPSQVSHGTGFTSFGLLKL
NT seq 786 nt NT seq  +upstreamnt  +downstreamnt
atgatcgaaacatacaaccaaacttctccccgatctgcggccactggactgcccatcagc
atgaaaatttttatgtatttacttactgtttttcttatcacccagatgattgggtcagca
ctttttgctgtgtatcttcatagaaggttggacaagatagaagatgaaaggaatcttcat
gaagattttgtattcatgaaaacgatacagagatgcaacacaggagaaagatccttatcc
ttactgaactgtgaggagattaaaagccagtttgaaggctttgtgaaggatataatgtta
aacaaagaggagacgaagaaagaaaacagctttgaaatgcaaaaaggtgatcagaatcct
caaattgcggcacatgtcataagtgaggccagcagtaaaacaacatctgtgttacagtgg
gctgaaaaaggatactacaccatgagcaacaacttggtaaccctggaaaatgggaaacag
ctgaccgttaaaagacaaggactctattatatctatgcccaagtcaccttctgttccaat
cgggaagcttcgagtcaagctccatttatagccagcctctgcctaaagtcccccggtaga
ttcgagagaatcttactcagagctgcaaatacccacagttccgccaaaccttgcgggcaa
caatccattcacttgggaggagtatttgaattgcaaccaggtgcttcggtgtttgtcaat
gtgactgatccaagccaagtgagccatggcactggcttcacgtcctttggcttactcaaa
ctctga

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